Article

Harnessing off-target effects

Nature Chemical Biology, Springer Nature, ISSN 1552-4469

Volume 13, 12, 2017

DOI:10.1038/nchembio.2519, Dimensions: pub.1092820159, PMID: 29161245,

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* Corresponding author

Affiliations

Organisations

  1. (1) University of Copenhagen, grid.5254.6, KU
  2. (2) Technical University of Denmark, grid.5170.3, DTU

Countries

Denmark

Continents

Europe

Description

The 'off-targets' of a drug are often poorly characterized yet could be harnessed in the treatment of complex diseases. A recent study used a small-molecule screening in non-small-cell lung cancer to repurpose an FDA-approved ALK/IGF1R inhibitor and uncover its mechanism of action.

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NORA University Profiles

University of Copenhagen

Technical University of Denmark

Danish Open Access Indicator

2017: Unused

Research area: Science & Technology

Danish Bibliometrics Indicator

2017: Level 2

Research area: NAT/TEK; SUND

Dimensions Citation Indicators

Times Cited: 3

Field Citation Ratio (FCR): 0.61

Relative Citation ratio (RCR): 0.13