Article

Characterization of the Hydrodynamics in a Miniaturized Dissolution Apparatus

Journal of Pharmaceutical Sciences, Elsevier, ISSN 1520-6017

Volume 107, 4, 2018

DOI:10.1016/j.xphs.2017.11.022, Dimensions: pub.1099635757, PMID: 29233728,

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  1. (1) University of Copenhagen, grid.5254.6, KU
  2. (2) Bioneer:FARMA, Universitetsparken 2, DK-2100 Copenhagen, Denmark

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Denmark

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Europe

Description

The hydrodynamics of a miniaturized dissolution apparatus was characterized using computational fluid dynamics simulations and analyzed in relation to the biorelevance and robustness of measurements of drug dissolution and precipitation kinetics from supersaturated drug solutions. The effect of using 3 different agitator geometries operated at 50, 100, 150, and 200 rpm as well as different positioning of an UV probe in the vessel was systematically evaluated. The computational fluid dynamics simulations were validated using a particle streak velocimetry experiment. The results show that the choice of agitator geometry influences the hydrodynamics of the system and indicates that an off-center probe position may result in more robust measurements. Furthermore, the study shows that the agitator geometry has a significant effect on supersaturation studies due to differences in the hydrodynamic shear produced by the agitator.

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University of Copenhagen

Danish Open Access Indicator

2018: Unused

Research area: Science & Technology

Danish Bibliometrics Indicator

2018: Level 2

Research area: Science & Technology

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Times Cited: 2

Field Citation Ratio (FCR): 0.97

Relative Citation ratio (RCR): 0