Article open access publication

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

Nature Genetics, Springer Nature, ISSN 1061-4036

Volume 50, 1, 2018

DOI:10.1038/s41588-017-0014-7, Dimensions: pub.1099864983, PMC: PMC5901974, PMID: 29273806,

Authors

Demenais, Florence * (1) (2)
Ang, Wei (6)
Brusselle, Guy G O (16) (17)
Bush, Andrew (4) (19)
Chung, Kian Fan (4) (19)
Farrall, Martin (24) (25)
Gajdos, Zofia (30) (31)
Heinrich, Joachim (41) (42)
Hirschhorn, Joel N (30) (31) (46)
Hofman, Albert (17) (46)
Hudson, Thomas J. (47) (48)
Hui, Jennie (6) (10) (49)
Imboden, Medea (50) (51)
James, Alan (6) (53)
Jarvelin, Marjo-Riitta (4) (55) (56)
Kantor, David B (31) (46)
Kumar, Rajesh (64) (65)
Kumar, Ashish (50) (51) (66)
Kuokkanen, Mikko (40) (43)
Lahousse, Lies (17) (67)
Laprise, Catherine (69) (70)
Lee, Young-Ae (72) (73)
Li, Guo (35)
Marenholz, Ingo (72) (73)
Melbye, Mads (27) (81) (82)
Melén, Erik (66) (83) (84)
Mohamdi, Hamida (1) (2)
Musk, Arthur W. (6) (53)
O'Connor, George T (88) (89)
Palmer, Cameron D (30) (31)
Palotie, Aarno (30) (40) (91)
Pershagen, Göran (66) (84)
Postma, Dirkje S. (61) (86)
Romieu, I Isabelle (95) (96)
Salam, Muhammad T. (32) (97)
Simpson, Angela (21) (100)
Stefansson, Kari (38) (39)
Tiesler, Carla M T (42) (105)
Tsunoda, Tatsuhiko (63) (106)
Vaysse, Amaury (1) (2)
Vedantam, Sailaja (30) (31)
von Mutius, Erika (105) (108)
Wickman, Magnus (54) (66)
Ober, Carole (111)
Nicolae, Dan L. * (112)

* Corresponding author

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  1. (1) Délégation Paris 11, grid.457369.a
  2. (2) Paris Diderot University, grid.7452.4
  3. (3) University of Colorado Denver, grid.241116.1
  4. (4) Imperial College London, grid.7445.2
  5. (5) University of Cologne, grid.6190.e
  6. (6) University of Western Australia, grid.1012.2
  7. (7) Columbia University, grid.21729.3f
  8. (8) Johns Hopkins University, grid.21107.35
  9. (9) University of Manitoba, grid.21613.37
  10. (10) Department of the Diagnostic Genomics Laboratory, PathWest Laboratory Medicine, Queen Elizabeth II Medical Centre, Nedlands, Western Australia, Australia
  11. (11) Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark
  12. (12) National University Hospital of Iceland, grid.410540.4
  13. (13) Wake Forest University, grid.241167.7
  14. (14) VU University Medical Center, grid.16872.3a
  15. (15) University of Leicester, Institute for Lung Health, Glenfield Hospital, Leicester, UK
  16. (16) Ghent University Hospital, grid.410566.0
  17. (17) Erasmus University Medical Center, grid.5645.2
  18. (18) University of California, San Francisco, grid.266102.1
  19. (19) National Health Service, grid.451052.7
  20. (20) University of British Columbia, grid.17091.3e
  21. (21) University of Manchester, grid.5379.8
  22. (22) Hospital Infantil de México Federico Gómez, grid.414757.4
  23. (23) Helsinki University Central Hospital, grid.15485.3d
  24. (24) University of Oxford, grid.4991.5
  25. (25) Wellcome Centre for Human Genetics, grid.270683.8
  26. (26) Institute of Biochemistry and Genetics of Ufa Scientific Centre, grid.429129.5
  27. (27) State Serum Institute, grid.6203.7
  28. (28) QIMR Berghofer Medical Research Institute, grid.1049.c
  29. (29) Research Institute of Medical Genetics of Russian Academy of Medical Sciences, grid.465310.5
  30. (30) Broad Institute, grid.66859.34
  31. (31) Boston Children's Hospital, grid.2515.3
  32. (32) University of Southern California, grid.42505.36
  33. (33) Utrecht University, grid.5477.1
  34. (34) University of Ulm, grid.6582.9
  35. (35) University of Washington, grid.34477.33
  36. (36) University of Bristol, grid.5337.2
  37. (37) University of Arizona, grid.134563.6
  38. (38) deCODE Genetics (Iceland), grid.421812.c
  39. (39) University of Iceland, grid.14013.37
  40. (40) University of Helsinki, grid.7737.4
  41. (41) Klinikum der Universität München, grid.411095.8
  42. (42) Institute of Epidemiology I, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Germany
  43. (43) National Institute for Health and Welfare, grid.14758.3f
  44. (44) University of Pennsylvania, grid.25879.31
  45. (45) Keio University, grid.26091.3c
  46. (46) Harvard University, grid.38142.3c
  47. (47) AbbVie Inc., Redwood City, CA, USA
  48. (48) Ontario Institute for Cancer Research, grid.419890.d
  49. (49) Busselton Population Medical Research Institute, Perth, Western Australia, Australia
  50. (50) Swiss Tropical and Public Health Institute, grid.416786.a
  51. (51) University of Basel, grid.6612.3
  52. (52) Kursk State Medical University, grid.411191.d
  53. (53) Sir Charles Gairdner Hospital, grid.3521.5
  54. (54) Uppsala University, grid.8993.b
  55. (55) Oulu University Hospital, grid.412326.0
  56. (56) University of Oulu, grid.10858.34
  57. (57) Western Sydney University, grid.1029.a
  58. (58) Kinderklinik Regensburg, grid.459443.b
  59. (59) Tampere University Hospital, grid.412330.7
  60. (60) Bashkir State University, grid.77269.3d
  61. (61) University Medical Center Groningen, grid.4494.d
  62. (62) University of Alberta, grid.17089.37
  63. (63) RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
  64. (64) Lurie Children's Hospital, grid.413808.6
  65. (65) Northwestern University, grid.16753.36
  66. (66) Karolinska Institute, grid.4714.6
  67. (67) Ghent University, grid.5342.0
  68. (68) Turku University Hospital, grid.410552.7
  69. (69) Centre de Santé et de Services Sociaux du Saguenay-Lac-Saint-Jean, Saguenay, QC, Canada
  70. (70) Département des Sciences Fondamentales, Université du Québec à Chicoutimi, Chicoutimi, Quebec, Canada
  71. (71) McGill University and Génome Québec Innovation Centre, grid.411640.6
  72. (72) Charité, grid.6363.0
  73. (73) Max Delbrück Center for Molecular Medicine, grid.419491.0
  74. (74) Tampere University, grid.502801.e
  75. (75) Henry Ford Health System, grid.239864.2
  76. (76) University of North Carolina at Chapel Hill, grid.10698.36
  77. (77) National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA
  78. (78) University of Virginia, grid.27755.32
  79. (79) University of Melbourne, grid.1008.9
  80. (80) National Center For Child Health and Development, grid.63906.3a
  81. (81) Stanford University, grid.168010.e
  82. (82) University of Copenhagen, grid.5254.6, KU
  83. (83) Sachs' Children and Youth Hospital, grid.416452.0
  84. (84) Stockholm County Council, grid.425979.4
  85. (85) Duke University, grid.26009.3d
  86. (86) University Medical Center Groningen, Department of Pulmonology, University of Groningen, Groningen, The Netherlands
  87. (87) University of Tsukuba, grid.20515.33
  88. (88) Boston University School of Medicine, grid.475010.7
  89. (89) National Heart Lung and Blood Institute, grid.279885.9
  90. (90) Siberian State Medical University, grid.412593.8
  91. (91) Massachusetts General Hospital, grid.32224.35
  92. (92) Brigham and Women's Hospital, grid.62560.37
  93. (93) King's College London, grid.13097.3c
  94. (94) Murdoch Children's Research Institute, grid.1058.c
  95. (95) Hubert Department of Global Health, Mory University, Atlanta, GA, USA
  96. (96) Instituto Nacional de Salud Pública, grid.415771.1
  97. (97) Department of Psychiatry, Kern Medical, Bakersfield, CA, USA
  98. (98) Aarhus University, grid.7048.b, AU
  99. (99) Institute of Metabolic Science, grid.470900.a
  100. (100) Manchester University NHS Foundation Trust, grid.498924.a
  101. (101) Institut Albert Bonniot, grid.418110.d
  102. (102) St George's, University of London, grid.264200.2
  103. (103) Netherlands Healthcare Inspectorate, The Hague, The Netherlands
  104. (104) Institute for Respiratory Health and Harry Perkins Institute of Medical Research, University of Western Australia and The Lung Health Clinic, Nedlands, Western Australia, Australia
  105. (105) Ludwig Maximilian University of Munich, grid.5252.0
  106. (106) Tokyo Medical and Dental University, grid.265073.5
  107. (107) Marien Hospital Wesel, grid.488381.e
  108. (108) German Center for Lung Research, grid.452624.3
  109. (109) Tougaloo College, grid.265109.9
  110. (110) University of Michigan, grid.214458.e
  111. (111) University of Chicago, grid.170205.1
  112. (112) Departments of Statistics, Human Genetics and Medicine, Section of Genetic Medicine, University of Chicago, Chicago, IL, USA

Description

We examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of individuals from ethnically diverse populations. We identified five new asthma loci, found two new associations at two known asthma loci, established asthma associations at two loci previously implicated in the comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlaps in genetic variants with autoimmune and inflammatory diseases. The enrichment in enhancer marks at asthma risk loci, especially in immune cells, suggested a major role of these loci in the regulation of immunologically related mechanisms.

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Danish Open Access Indicator

2018: Realized

Research area: Medicine

Danish Bibliometrics Indicator

2018: Level 3

Research area: Medicine

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Times Cited: 156

Field Citation Ratio (FCR): 50

Relative Citation ratio (RCR): 13.57

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Green, Published