Sunlight-driven Environmental Benign Production of Bioactive Natural Products with Focus on Diterpenoids and the Pathways Involved in their Formation

CHIMIA International Journal for Chemistry, Swiss Chemical Society, ISSN 0009-4293

Volume 71, 12, 2017

DOI:10.2533/chimia.2017.851, Dimensions: pub.1100115178, PMID: 29289247,



  1. (1) University of Copenhagen, grid.5254.6, KU






Diterpenoids are high value compounds characterized by high structural complexity. They constitute the largest class of specialized metabolites produced by plants. Diterpenoids are flexible molecules able to engage in specific binding to drug targets like receptors and transporters. In this review we provide an account on how the complex pathways for diterpenoids may be elucidated. Following plant pathway discovery, the compounds may be produced in heterologous hosts like yeasts and E. coli. Environmentally contained production in photosynthetic cells like cyanobacteria, green algae or mosses are envisioned as the ultimate future production system.

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