Article open access publication

Diagnosis, treatment, and response assessment in solitary plasmacytoma: updated recommendations from a European Expert Panel

Journal of Hematology & Oncology, Springer Nature, ISSN 1756-8722

Volume 11, 1, 2018

DOI:10.1186/s13045-017-0549-1, Dimensions: pub.1100433830, PMC: PMC5771205, PMID: 29338789,



  1. (1) Centre Hospitalier Universitaire de Liège, grid.411374.4
  2. (2) Clinica Universidad de Navarra, grid.411730.0
  3. (3) University of Bologna, grid.6292.f
  4. (4) Centre Hospitalier Universitaire de Poitiers, grid.411162.1
  5. (5) Department of Hematology, Hospital Clínic de Barcelona, IDIBAPS, Barcelona, Spain
  6. (6) National University Hospital of Iceland, grid.410540.4
  7. (7) Centre Hospitalier Universitaire de Nantes, grid.277151.7
  8. (8) Odense University Hospital, grid.7143.1, Southern Denmark Region
  9. (9) National and Kapodistrian University of Athens, grid.5216.0
  10. (10) Complejo Hospitalario de Salamanca, grid.411258.b
  11. (11) Universitair Ziekenhuis Leuven, grid.410569.f
  12. (12) University Medical Center Hamburg-Eppendorf, grid.13648.38
  13. (13) Ankara University, grid.7256.6
  14. (14) Wilhelminen Hospital, grid.417109.a
  15. (15) University of Pavia, grid.8982.b
  16. (16) VU University Medical Center, grid.16872.3a
  17. (17) University Medical Center Freiburg, grid.7708.8


Solitary plasmacytoma is an infrequent form of plasma cell dyscrasia that presents as a single mass of monoclonal plasma cells, located either extramedullary or intraosseous. In some patients, a bone marrow aspiration can detect a low monoclonal plasma cell infiltration which indicates a high risk of early progression to an overt myeloma disease. Before treatment initiation, whole body positron emission tomography-computed tomography or magnetic resonance imaging should be performed to exclude the presence of additional malignant lesions. For decades, treatment has been based on high-dose radiation, but studies exploring the potential benefit of systemic therapies for high-risk patients are urgently needed. In this review, a panel of expert European hematologists updates the recommendations on the diagnosis and management of patients with solitary plasmacytoma.


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Times Cited: 28

Field Citation Ratio (FCR): 24.55

Relative Citation ratio (RCR): 3.94

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