Article open access publication

Development of electrosprayed mucoadhesive chitosan microparticles

Carbohydrate Polymers, Elsevier, ISSN 1879-1344

Volume 190, 2018

DOI:10.1016/j.carbpol.2018.02.062, Dimensions: pub.1101199824, PMID: 29628244,

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  1. (1) Technical University of Denmark, grid.5170.3, DTU
  2. (2) University of Münster, grid.5949.1
  3. (3) University of Leeds, grid.9909.9

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Denmark

Germany

United Kingdom

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Europe

Description

The efficacy of chitosan (CS) to be used as drug delivery carrier has previously been reported. However, limited work has been pursued to produce stable and mucoadhesive CS electrosprayed particles for oral drug delivery, which is the aim of this study. Various CS types with different molecular weight (MW), degree of deacetylation (DD), and degree of polymerization (DP) were assessed. In addition, the effect of the solvent composition was also investigated. Results showed that stable CS electrosprayed particles can be produced by dissolving 3% w/v of low MW CS in mixtures of aqueous acetic acid and ethanol (50/50% v/v). The stable CS particles displayed diameters of approximately 1 μm as determined by dynamic light scattering. The zeta potential of these particles was found to be approximately 40 mV confirming the mucoadhesion properties of these CS electrosprayed particles and its potential to be used as drug delivery carrier.

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Technical University of Denmark

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2018: Realized

Research area: Science & Technology

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2018: Level 1

Research area: Science & Technology

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Times Cited: 27

Field Citation Ratio (FCR): 7.19

Relative Citation ratio (RCR): 2.92

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Green, Published