Article

Synthesis and antioxidant capacity of novel stable 5-tellurofuranose derivatives

Chemical Communications, Royal Society of Chemistry (RSC), ISSN 1359-7345

Volume 54, 24, 2018

DOI:10.1039/c8cc00565f, Dimensions: pub.1101218483, PMID: 29505059,

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  1. (1) University of Copenhagen, grid.5254.6, KU
  2. (2) University of Melbourne, grid.1008.9
  3. (3) Federal University of Pelotas, grid.411221.5
  4. (4) Dept. of Biomedical Sciences, University of Copenhagen, Panum Institute, Blegdamsvej 3, DK-2200, Copenhagen, Denmark. davies@sund.ku.dk and Seleno Therapeutics Pty. Ltd, Brighton East, Victoria 3187, Australia. chschiesser@gmail.com.
  5. (5) Seleno Therapeutics Pty. Ltd, Brighton East, Victoria 3187, Australia. chschiesser@gmail.com.

Description

Novel stable tellurium-containing carbohydrate derivatives are prepared from hexitols and pentitols through a double nucleophilic substitution with NaHTe in PEG-400. These tellurosugars react at very high rates with two-electron oxidants, including hypochlorous and peroxynitrous acid, formed at sites of inflammation, and show considerable promise as protective agents against oxidative damage.

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NORA University Profiles

University of Copenhagen

Danish Open Access Indicator

2018: Unused

Research area: Medicine

Danish Bibliometrics Indicator

2018: Level 2

Research area: Medicine

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Times Cited: 5

Field Citation Ratio (FCR): 1.63

Relative Citation ratio (RCR): 0