Article open access publication

Bacteriophage Interactions with Marine Pathogenic Vibrios: Implications for Phage Therapy

Antibiotics, MDPI, ISSN 2079-6382

Volume 7, 1, 2018

DOI:10.3390/antibiotics7010015, Dimensions: pub.1101239629, PMC: PMC5872126, PMID: 29495270,

Affiliations

Organisations

  1. (1) University of Copenhagen, grid.5254.6, KU
  2. (2) Hellenic Centre for Marine Research, grid.410335.0

Countries

Denmark

Greece

Continents

Europe

Description

A global distribution in marine, brackish, and freshwater ecosystems, in combination with high abundances and biomass, make vibrios key players in aquatic environments, as well as important pathogens for humans and marine animals. Incidents of Vibrio-associated diseases (vibriosis) in marine aquaculture are being increasingly reported on a global scale, due to the fast growth of the industry over the past few decades years. The administration of antibiotics has been the most commonly applied therapy used to control vibriosis outbreaks, giving rise to concerns about development and spreading of antibiotic-resistant bacteria in the environment. Hence, the idea of using lytic bacteriophages as therapeutic agents against bacterial diseases has been revived during the last years. Bacteriophage therapy constitutes a promising alternative not only for treatment, but also for prevention of vibriosis in aquaculture. However, several scientific and technological challenges still need further investigation before reliable, reproducible treatments with commercial potential are available for the aquaculture industry. The potential and the challenges of phage-based alternatives to antibiotic treatment of vibriosis are addressed in this review.

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Sustainable Development Goals

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University of Copenhagen

Dimensions Citation Indicators

Times Cited: 26

Field Citation Ratio (FCR): 8.46

Relative Citation ratio (RCR): 3.58

Open Access Info

Pure Gold