Article open access publication

Drug loaded biodegradable polymer microneedles fabricated by hot embossing

Microelectronic Engineering, Elsevier, ISSN 1873-5568

Volume 195, 2018

DOI:10.1016/j.mee.2018.03.024, Dimensions: pub.1101818672,

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  1. (1) Technical University of Denmark, grid.5170.3, DTU

Countries

Denmark

Continents

Europe

Description

This study demonstrates a fast low temperature method for fabrication of drug loaded polymer microneedles (MNs). First, arrays of tapered pillar MNs with a length of 275 ± 3 μm (mean ± SD) and a diameter of 84 ± 1 μm were fabricated in Si with a three-step deep reactive ion etching (DRIE) process. The Si MNs were used as a template for fabrication of polydimethylsiloxane (PDMS) stamps. The stamps were applied for replication of the MNs in spin coated poly‑ε‑caprolactone (PCL) films by hot embossing at 60 °C and a pressure of 1.4 MPa for 3 min. The resulting PCL MNs perfectly resembled the Si MNs and had a length of 270 ± 5 μm and a diameter of 84 ± 3 μm. The MNs had sufficient mechanical strength to penetrate the surface of a 10 w/w% gelatine gel without deformation. Finally, PCL MNs containing 20 w/w% of furosemide were fabricated and drug release by diffusion was demonstrated.

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Technical University of Denmark

Danish Open Access Indicator

2018: Blocked

Research area: Science & Technology

Danish Bibliometrics Indicator

2018: Level 2

Research area: Science & Technology

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Times Cited: 11

Field Citation Ratio (FCR): 3.79

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Green, Submitted