Article open access publication

A constitutively expressed antifungal peptide protects Tenebrio molitor during a natural infection by the entomopathogenic fungus Beauveria bassiana

Developmental & Comparative Immunology, Elsevier, ISSN 1879-0089

Volume 86, 2018

DOI:10.1016/j.dci.2018.04.015, Dimensions: pub.1103600247, PMID: 29698631,


* Corresponding author



  1. (1) University of Copenhagen, grid.5254.6, KU
  2. (2) Free University of Berlin, grid.14095.39







Antimicrobial peptides have been well studied in the context of bacterial infections. Antifungal peptides have received comparatively less attention. Fungal pathogens of insects and their hosts represent a unique opportunity to study host-pathogen interactions due to the million of years of co-evolution they share. In this study, we investigated role of a constitutively expressed thaumatin-like peptide with antifungal activity expressed by the mealworm beetle Tenebrio molitor, named Tenecin 3, during a natural infection with the entomopathogenic fungus Beauveria bassiana. We monitored the effect of the expression of Tenecin 3 on the survival of infected hosts as well as on the progression of the fungal infection inside the host. Finally, we tested the activity of Tenecin 3 against B. bassiana. These findings could help improving biocontrol strategies and help understanding the evolution of antifungal peptides as a defense mechanism.

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2018: Unused

Research area: Science & Technology

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2018: Level 1

Research area: Science & Technology

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Times Cited: 7

Field Citation Ratio (FCR): 2.79

Relative Citation ratio (RCR): 1.46

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