Article open access publication

A constitutively expressed antifungal peptide protects Tenebrio molitor during a natural infection by the entomopathogenic fungus Beauveria bassiana

Developmental & Comparative Immunology, Elsevier, ISSN 1879-0089

Volume 86, 2018

DOI:10.1016/j.dci.2018.04.015, Dimensions: pub.1103600247, PMID: 29698631,

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  1. (1) University of Copenhagen, grid.5254.6, KU
  2. (2) Free University of Berlin, grid.14095.39

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Denmark

Germany

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Europe

Description

Antimicrobial peptides have been well studied in the context of bacterial infections. Antifungal peptides have received comparatively less attention. Fungal pathogens of insects and their hosts represent a unique opportunity to study host-pathogen interactions due to the million of years of co-evolution they share. In this study, we investigated role of a constitutively expressed thaumatin-like peptide with antifungal activity expressed by the mealworm beetle Tenebrio molitor, named Tenecin 3, during a natural infection with the entomopathogenic fungus Beauveria bassiana. We monitored the effect of the expression of Tenecin 3 on the survival of infected hosts as well as on the progression of the fungal infection inside the host. Finally, we tested the activity of Tenecin 3 against B. bassiana. These findings could help improving biocontrol strategies and help understanding the evolution of antifungal peptides as a defense mechanism.

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University of Copenhagen

Danish Open Access Indicator

2018: Unused

Research area: Science & Technology

Danish Bibliometrics Indicator

2018: Level 1

Research area: Science & Technology

Dimensions Citation Indicators

Times Cited: 7

Field Citation Ratio (FCR): 2.79

Relative Citation ratio (RCR): 1.46

Open Access Info

Green, Submitted