Article

Gut metabolome meets microbiome: A methodological perspective to understand the relationship between host and microbe

Methods, Elsevier, ISSN 1557-766X

Volume 149, 2018

DOI:10.1016/j.ymeth.2018.04.029, Dimensions: pub.1103678385, PMID: 29715508,

Authors

Orešič, Matej (1) (2)

* Corresponding author

Affiliations

Organisations

  1. (1) Turku Centre for Biotechnology, grid.452861.c
  2. (2) Örebro University, grid.15895.30
  3. (3) Aarhus University, grid.7048.b, AU

Countries

Sweden

Finland

Denmark

Continents

Europe

Description

It is well established that gut microbes and their metabolic products regulate host metabolism. The interactions between the host and its gut microbiota are highly dynamic and complex. In this review we present and discuss the metabolomic strategies to study the gut microbial ecosystem. We highlight the metabolic profiling approaches to study faecal samples aimed at deciphering the metabolic product derived from gut microbiota. We also discuss how metabolomics data can be integrated with metagenomics data derived from gut microbiota and how such approaches may lead to better understanding of the microbial functions. Finally, the emerging approaches of genome-scale metabolic modelling to study microbial co-metabolism and host-microbe interactions are highlighted.

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NORA University Profiles

Aarhus University

Danish Open Access Indicator

2018: Unused

Research area: Science & Technology

Danish Bibliometrics Indicator

2018: Level 1

Research area: Science & Technology

Dimensions Citation Indicators

Times Cited: 31

Field Citation Ratio (FCR): 23.98

Relative Citation ratio (RCR): 3.52