Article open access publication

Microfabricated devices for oral drug delivery

Lab on a Chip, Royal Society of Chemistry (RSC), ISSN 1473-0197

Volume 18, 16, 2018

DOI:10.1039/c8lc00408k, Dimensions: pub.1105252476, PMID: 29975383,

Authors

Nielsen, Line Hagner (1) (2) (3) (4)
Keller, Stephan Sylvest (1) (2) (3) (4)
Boisen, Anja (1) (2) (3) (4)

Affiliations

Organisations

  1. (1) 2800 Kgs, Lyngby
  2. (2) Denmark
  3. (3) Department of Micro- and Nanotechnology
  4. (4) Technical University of Denmark, grid.5170.3, DTU

Countries

Denmark

Continents

Europe

Description

Oral administration of drugs is most convenient for patients and therefore the ultimate goal when developing new medication. The physical barriers in the body, low pH of the stomach and degradation by enzymes in the gastrointestinal tract are a few of the obstacles to succeeding with oral drug delivery. Microfabricated devices show promise to overcome some of these hindrances and thereby improve the bioavailability of drugs after oral administration. There is an increasing focus on microfabricated oral drug delivery systems, and so far there have been three main groups of designs: patch-like structures, microcontainers and microwells. Here, we review the newest development in top-down microfabricated devices for oral drug delivery with coverage of the aspects of design, choice of material and fabrication techniques. Furthermore, the drug loading techniques and methods for testing are discussed. In addition, we discuss the future perspectives for microfabricated devices.

Funders

Research Categories

Main Subject Area

Fields of Research

Links & Metrics

NORA University Profiles

Technical University of Denmark

Danish Open Access Indicator

2018: Realized

Research area: Science & Technology

Danish Bibliometrics Indicator

2018: Level 1

Research area: Science & Technology

Dimensions Citation Indicators

Times Cited: 14

Field Citation Ratio (FCR): 6.26

Relative Citation ratio (RCR): 2.69

Open Access Info

Green, Submitted