Article open access publication

CDy14: a novel biofilm probe targeting exopolysaccharide Psl

Chemical Communications, Royal Society of Chemistry (RSC), ISSN 1359-7345

Volume 54, 84, 2018

DOI:10.1039/c8cc05544k, Dimensions: pub.1106545457, PMID: 30204158,

Authors

Kwon, Haw-Young (1) (2) (3)
Kim, Jun-Young (4) (5)
Lee, Jung Yeol (1) (6) (7)
Hultqvist, Louise Dahl (9) (10) (11)
Xu, Wang (5) (12)
Rybtke, Morten (9) (10) (11)
Tolker-Nielsen, Tim (9) (10) (11)
Kim, Jong-Jin (1) (2) (3)
Kang, Nam-Young (1) (6) (7)
Yang, Liang (5) (8)
Park, Sung-Jin (4) (5)
Givskov, Michael (5) (8) (9) (10) (11)
Chang, Young-Tae (1) (2) (3) (4) (5)

Affiliations

Organisations

  1. (1) Republic of Korea
  2. (2) Center for Self-assembly and Complexity, Institute for Basic Science (IBS)
  3. (3) Pohang 37673
  4. (4) Singapore Bioimaging Consortium, Agency for Science, Technology and Research
  5. (5) Singapore
  6. (6) Daegu
  7. (7) New drug discovery Center, Daegu-Gyeongbuk Medivalley Innovation Foundation (DGMIF)
  8. (8) Nanyang Technological University, grid.59025.3b
  9. (9) DK 2200 Copenhagen
  10. (10) Denmark
  11. (11) University of Copenhagen, grid.5254.6, KU
  12. (12) Department of Chemistry & Med Chem Program, Life Sciences Institute, National University of Singapore

Countries

Singapore

Denmark

Continents

Asia

Europe

Description

Detection of biofilm bacteria would be an ideal method for the physicians to diagnose chronic bacterial infections directly, but there are few imaging probes available so far. Here, we report the development of a novel biofilm detecting fluorescent probe, CDy14, through an unbiased screening of a fluorescence library and elucidated its binding partner Psl, an exopolysaccharide of the biofilm.

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University of Copenhagen

Danish Open Access Indicator

2018: Unused

Research area: Medicine

Danish Bibliometrics Indicator

2018: Level 2

Research area: Medicine

Dimensions Citation Indicators

Times Cited: 1

Relative Citation ratio (RCR): 0.27

Open Access Info

Green, Submitted