Article

Visualizing biofilm by targeting eDNA with long wavelength probe CDr15

Biomaterials Science, Royal Society of Chemistry (RSC), ISSN 2047-4830

Volume 7, 9, 2019

DOI:10.1039/c9bm00152b, Dimensions: pub.1118145966, PMID: 31329200,

Authors

Kwon, Haw-Young (1) (2) (3) (4)
Kim, Jun-Young (5) (6) (7) (8)
Liu, Xiao (1) (2) (3) (4) (9)
Lee, Jung Yeol (4) (10) (11) (12)
Yam, Joey Kuok Hoong (8) (13) (14)
Dahl Hultqvist, Louise (15) (16) (17) (18) (19)
Xu, Wang (8) (20) (21) (22)
Rybtke, Morten (15) (16) (17) (18) (19)
Tolker-Nielsen, Tim (15) (16) (17) (18) (19)
Heo, Wooseok (9) (23) (24) (25)
Kim, Jong-Jin (1) (2) (3) (4)
Kang, Nam-Young (4) (10) (11) (12) (26)
Joo, Taiha (9) (23) (24) (25)
Yang, Liang (8) (13) (14)
Park, Sung-Jin (5) (6) (7) (8)
Givskov, Michael (8) (13) (14) (18) (19)
Chang, Young-Tae (1) (2) (3) (4) (7)

Affiliations

Organisations

  1. (1) Center for Self-assembly and Complexity
  2. (2) Institute for Basic Science, grid.410720.0
  3. (3) Pohang 37673
  4. (4) Republic of Korea
  5. (5) Agency for Science
  6. (6) Technology and Research
  7. (7) Bioimaging Consortium
  8. (8) Singapore
  9. (9) Department of Chemistry
  10. (10) Daegu
  11. (11) Daegu-Gyeongbuk Medivalley Innovation Foundation (DGMIF)
  12. (12) New drug discovery Center
  13. (13) Nanyang Technological University, grid.59025.3b
  14. (14) Singapore Centre for Environmental Life Sciences Engineering (SCELSE)
  15. (15) DK 2200 Copenhagen
  16. (16) Faculty of Health and Medical Sciences
  17. (17) University of Copenhagen, grid.5254.6, KU
  18. (18) Costerton Biofilm Center
  19. (19) Department of Immunology and Microbiology
  20. (20) Department of Chemistry & Med Chem Program
  21. (21) Life Sciences Institute
  22. (22) National University of Singapore, grid.4280.e
  23. (23) Korea
  24. (24) Pohang
  25. (25) Pohang University of Science and Technology (POSTECH)
  26. (26) Department of Creative IT Engineering

Countries

South Korea

Denmark

Singapore

Continents

Asia

Europe

Description

Detection of the biofilm of bacteria would be a counter strategy to detect hidden bacteria in their camouflage. Through unbiased screening of bacteria biofilm, we discovered a long wavelength probe CDr15 with extracellular DNA as the molecular target. CDr15 revealed a real-time geometric distribution of eDNA in a 3D bacterial colony.

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