Article open access publication

Polygenic risk scores and breast and epithelial ovarian cancer risks for carriers of BRCA1 and BRCA2 pathogenic variants

Genetics in Medicine, Springer Nature, ISSN 1530-0366

Volume 22, 10, 2020

DOI:10.1038/s41436-020-0862-x, Dimensions: pub.1129318745, PMC: PMC7521995, PMID: 32665703,

Authors

Andrieu, Nadine (7) (8) (9) (10)
Arnold, Norbert (13) (14)
Benitez, Javier J (20) (21)
Borg, Åke (28)
Campbell, Ian (38) (39)
Domchek, Susan M (30) (31)
Evans, D. Gareth (55) (56)
Friedman, Eitan (62) (63)
Hulick, Peter J (80) (81)
James, Paul Andrew (38) (39)
Karlan, Beth Young (64) (89)
Kwong, Ava (93) (94) (95)
Lasset, Christine (96) (97)
Lester, Jenny (64) (89)
Lesueur, Fabienne El-Khoury (7) (8) (9) (10)
Mebirouk, Noura (7) (8) (9) (10)
Niederacher, Dieter (107) (108)
Ong, Kai-Ren (111)
Osorio, Ana (20) (21)
Papi, Laura (114)
Park, Sue K. (115)
Peixoto, Ana (119)
Phillips, Kelly-Anne A (38) (39) (121)
Ramus, Susan J (124) (125)
Rennert, Gad (126)
Salani, Ritu (129)
Schuster, Hélène (130) (131) (132)
Shah, Payal D. (30) (31)
Side, Lucy E (133)
Southey, Melissa Caroline (38) (134) (135)
Teo, Soo-Hwang (140) (141)
Tischkowitz, Marc Derek (1) (143) (144)
Trainer, Alison H (38) (39)
Tung, Nadine (145)
Vega, Ana Belén (20) (147) (148)
Walker, Lisa (149)
Yang, Xin (1)

* Corresponding author

Affiliations

Organisations

  1. (1) University of Cambridge, grid.5335.0
  2. (2) Antoni van Leeuwenhoek Hospital, grid.430814.a
  3. (3) Chapel Allerton Hospital, grid.413818.7
  4. (4) Great Ormond Street Hospital for Children NHS Foundation Trust, grid.424537.3
  5. (5) Helsinki University Hospital, grid.15485.3d
  6. (6) University of Helsinki, grid.7737.4
  7. (7) French Institute of Health and Medical Research, grid.7429.8
  8. (8) Mines ParisTech, grid.58140.38
  9. (9) PSL Research University, grid.440907.e
  10. (10) Institute Curie, grid.418596.7
  11. (11) University of Toronto, grid.17063.33
  12. (12) Lunenfeld-Tanenbaum Research Institute, grid.250674.2
  13. (13) Kiel University, grid.9764.c
  14. (14) University Hospital Schleswig-Holstein, grid.412468.d
  15. (15) The University of Texas MD Anderson Cancer Center, grid.240145.6
  16. (16) Fondazione IRCCS Istituto Nazionale dei Tumori, grid.417893.0
  17. (17) Vall d'Hebron Hospital Universitari, grid.411083.f
  18. (18) National University Hospital of Iceland, grid.410540.4
  19. (19) University of Iceland, grid.14013.37
  20. (20) Centre for Biomedical Network Research on Rare Diseases, grid.452372.5
  21. (21) Spanish National Cancer Research Centre, grid.7719.8
  22. (22) Centre Franois Baclesse, grid.476192.f
  23. (23) Pomeranian Medical University, grid.107950.a
  24. (24) University of California, San Francisco, grid.266102.1
  25. (25) Maastricht University Medical Centre, grid.412966.e
  26. (26) European Institute of Oncology, grid.15667.33
  27. (27) Zealand University Hospital, grid.476266.7, Zealand Region
  28. (28) Lund University, grid.4514.4
  29. (29) National Institute of Oncology, grid.419617.c
  30. (30) University of Pennsylvania, grid.25879.31
  31. (31) University of Pennsylvania Health System, grid.412701.1
  32. (32) Centre for Life, grid.419328.5
  33. (33) Royal Devon and Exeter Hospital, grid.416118.b
  34. (34) Catalan Institute of Oncology, grid.418701.b
  35. (35) Huntsman Cancer Institute, grid.479969.c
  36. (36) Hospital Clínico San Carlos, grid.411068.a
  37. (37) Azienda Ospedaliera Universitaria Pisana, grid.144189.1
  38. (38) University of Melbourne, grid.1008.9
  39. (39) Peter MacCallum Cancer Centre, grid.1055.1
  40. (40) Aarhus University Hospital, grid.154185.c, Central Denmark Region
  41. (41) Columbia University, grid.21729.3f
  42. (42) Ghent University, grid.5342.0
  43. (43) Centre Hospitalier Universitaire de Besançon, grid.411158.8
  44. (44) Sheffield Children's Hospital, grid.413991.7
  45. (45) Fox Chase Cancer Center, grid.249335.a
  46. (46) Queen Elizabeth University Hospitals, Department of Clinical Genetics, Glasgow, UK
  47. (47) Centre Hospitalier Universitaire de Nantes, grid.277151.7
  48. (48) Leiden University Medical Center, grid.10419.3d
  49. (49) City Of Hope National Medical Center, grid.410425.6
  50. (50) University of Pretoria, grid.49697.35
  51. (51) Centre Hospitalier Universitaire de Québec, grid.411081.d
  52. (52) Institute of Cancer Research, grid.18886.3f
  53. (53) Rigshospitalet, grid.475435.4, Capital Region
  54. (54) Leipzig University, grid.9647.c
  55. (55) St Mary's Hospital, grid.416523.7
  56. (56) University of Manchester, grid.5379.8
  57. (57) Centre Georges François Leclerc, grid.418037.9
  58. (58) DHU Dijon, Centre de Génétique, Dijon, France
  59. (59) Masaryk Memorial Cancer Institute, grid.419466.8
  60. (60) National Centre of Scientific Research Demokritos, grid.6083.d
  61. (61) NHMRC Clinical Trials, ANZ GOTG Coordinating Centre, Camperdown, NSW, Australia
  62. (62) Tel Aviv University, grid.12136.37
  63. (63) Sheba Medical Center, grid.413795.d
  64. (64) University of California, Los Angeles, grid.19006.3e
  65. (65) Dana-Farber Cancer Institute, grid.65499.37
  66. (66) University of Würzburg, grid.8379.5
  67. (67) CH Niort, Service Régional Oncogénétique Poitou-Charentes, Niort, France
  68. (68) Hospices Civils de Lyon, grid.413852.9
  69. (69) University of Kansas Medical Center, grid.412016.0
  70. (70) University of Utah, grid.223827.e
  71. (71) National Cancer Institute, grid.48336.3a
  72. (72) Medical University of Vienna, grid.22937.3d
  73. (73) University of Cologne, grid.6190.e
  74. (74) German Cancer Research Center, grid.7497.d
  75. (75) National Health Service, grid.451052.7
  76. (76) University Hospital Leipzig, grid.411339.d
  77. (77) Erasmus MC Cancer Institute, grid.508717.c
  78. (78) University of Münster, grid.5949.1
  79. (79) Mayo Clinic, grid.66875.3a
  80. (80) NorthShore University HealthSystem, grid.240372.0
  81. (81) University of Chicago, grid.170205.1
  82. (82) Institute of Oncology NN Petrov, grid.465337.0
  83. (83) Georgetown University Medical Center, grid.411667.3
  84. (84) Guy's and St Thomas' NHS Foundation Trust, grid.420545.2
  85. (85) State Research Institute Centre for Innovative Medicine, grid.493509.2
  86. (86) Vilnius University Hospital Santariskiu Klinikos, grid.426597.b
  87. (87) Stanford University, grid.168010.e
  88. (88) Memorial Sloan Kettering Cancer Center, grid.51462.34
  89. (89) Cedars-Sinai Medical Center, grid.50956.3f
  90. (90) TU Dresden, grid.4488.0
  91. (91) University Medical Center Utrecht, grid.7692.a
  92. (92) Odense University Hospital, grid.7143.1, Southern Denmark Region
  93. (93) Cancer Genetics Centre, Hong Kong Hereditary Breast Cancer Family Registry, Happy Valley, Hong Kong
  94. (94) Hong Kong Sanatorium and Hospital, grid.414329.9
  95. (95) University of Hong Kong, grid.194645.b
  96. (96) Centre Léon Bérard, grid.418116.b
  97. (97) University of Lyon System, grid.25697.3f
  98. (98) Karolinska Institute, grid.4714.6
  99. (99) Magee-Womens Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
  100. (100) Centre Antoine Lacassagne, grid.417812.9
  101. (101) Amsterdam UMC, location AMC, Department of Clinical Genetics, Amsterdam, The Netherlands
  102. (102) Ludwig-Maximilians-Universität München, grid.5252.0
  103. (103) Radboud University Nijmegen Medical Centre, grid.10417.33
  104. (104) Roswell Park Cancer Institute, grid.240614.5
  105. (105) Istituto Oncologico Veneto, grid.419546.b
  106. (106) University Health Network, grid.231844.8
  107. (107) Düsseldorf University Hospital, grid.14778.3d
  108. (108) Heinrich Heine University Düsseldorf, grid.411327.2
  109. (109) Latvian Biomedical Research and Study Centre, grid.419210.f
  110. (110) Institute Paoli-Calmettes, grid.418443.e
  111. (111) Birmingham Women's Hospital, grid.423077.5
  112. (112) Cambridge University Hospitals NHS Foundation Trust, grid.24029.3d
  113. (113) Charité - University Medicine Berlin, grid.6363.0
  114. (114) University of Florence, grid.8404.8
  115. (115) Seoul National University, grid.31501.36
  116. (116) QIMR Berghofer Medical Research Institute, grid.1049.c
  117. (117) Aalborg Hospital, grid.27530.33, North Denmark Region
  118. (118) Aalborg University, grid.5117.2, AAU
  119. (119) Portuguese Oncology Institute, grid.418711.a
  120. (120) FIRC Institute of Molecular Oncology, grid.7678.e
  121. (121) St Vincent's Hospital, grid.413105.2
  122. (122) Bellvitge Biomedical Research Institute, grid.418284.3
  123. (123) Rechts der Isar Hospital, grid.15474.33
  124. (124) The Kinghorn Cancer Centre, grid.410697.d
  125. (125) UNSW Sydney, grid.1005.4
  126. (126) Carmel Medical Center, grid.413469.d
  127. (127) Yale University, grid.47100.32
  128. (128) Vejle Sygehus, grid.417271.6, Southern Denmark Region
  129. (129) The Ohio State University, grid.261331.4
  130. (130) Institut de Cancérologie Strasbourg Europe, ICANS, Strasbourg, France
  131. (131) Unité d’Oncogénétique Centre de Lutte contre le Cancer Paul Strauss, Strasbourg, France
  132. (132) University of Strasbourg, grid.11843.3f
  133. (133) Princess Anne Hospital, grid.415216.5
  134. (134) Cancer Council Victoria, grid.3263.4
  135. (135) Monash University, grid.1002.3
  136. (136) Hannover Medical School, grid.10423.34
  137. (137) University of Paris, grid.508487.6
  138. (138) University Hospital Heidelberg, grid.5253.1
  139. (139) University of Porto, grid.5808.5
  140. (140) Cancer Research Malaysia, grid.507182.9
  141. (141) University of Malaya, grid.10347.31
  142. (142) Magee-Womens Hospital, University of Pittsburgh School of Medicine, Department of Medicine, Pittsburgh, PA, USA
  143. (143) McGill University, grid.14709.3b
  144. (144) NIHR Cambridge Dementia Biomedical Research Unit, grid.454369.9
  145. (145) Beth Israel Deaconess Medical Center, grid.239395.7
  146. (146) Amsterdam UMC, location VUmc, Department of Clinical Genetics, Amsterdam, The Netherlands
  147. (147) Complejo Hospitalario Universitario de Santiago, grid.411048.8
  148. (148) Fundación Pública Galega de Medicina Xenómica, grid.443929.1
  149. (149) Oxford University Hospitals NHS Trust, grid.410556.3
  150. (150) University Hospital Ulm, grid.410712.1

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