Preprint open access publication

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

bioRxiv, Cold Spring Harbor Laboratory,

2020

DOI:10.1101/2020.07.23.217646, Dimensions: pub.1129673551,

Authors

Chen, Ji * (1) (2)
Wu, Ying (4)
Horikoshi, Momoko (10) (11) (12)
Waage, Johannes Eichler (15) (16) (17)
Hang, Kei (20) (21)
Yao, Jie (22)
Kaakinen, Marika A (23) (30)
März, Winfried (32) (33) (34)
Nolte, Ilja Maria (25) (26)
Schurmann, Claudia (37) (38)
Sim, Xue Ling (6) (39)
Wu, Peitao (18)
Zhang, Weihua (23) (41)
Cade, Brian Edmand (24) (44)
Chai, Jin-Fang (39) (45)
Chai, Xiao-Ran (39) (45) (46)
Fatumo, Segun A (53) (54) (55)
Hai, Yang (58)
He, Jing (60)
Huang, Tao (62)
Li, Man (70)
Liu, Jun (12) (51)
Lyssenko, Valeriya (72) (73)
Mangino, Massimo (74) (75)
Marzi, Carola S (76) (77)
Rueedi, Rico (84) (85)
Sanna, Serena (25) (26) (81)
Saxena, Richa (42) (44) (86)
Smith, Albert V (87) (88)
Verweij, Niek (25) (26) (94)
Wang, Chaolong (96) (97)
Wang, Nan (98)
Wong, Andrew (100)
Xie, Tian (25) (26)
Zhao, Wei (6)
Baldassarre, Damiano (102) (103)
Campbell, Archie I (67) (106)
Chang, Yi-Cheng (47) (107) (108)
De Geus, Eco J C N (27) (28)
Gao, Yutang (111)
Goel, Anuj (11) (12)
Han, Sohee (65)
Herder, Christian (76) (112) (113)
Hsieh, Chang-Hsun (114) (115)
Kuusisto, Johanna K (124) (125)
Li, Honglan (127) (128)
Lin, Shih-Yi (130) (131)
Linneberg, Allan R (17) (133)
Liu, Jianjun (39) (45) (97)
Nabika, Toru (136)
Peters, Annette (76) (77) (138)
Qi, Qibin (139)
Raven, Dennis (25) (26)
Reiner, Alex (141)
Schürmann, Annette (76) (143)
Shi, Jin-Xiu (144)
Wang, Tao (139)
Xiang, Yong-Bing (127) (128)
An, Ping (152)
Bergmann, Sven Michael (84) (85) (155)
Bisgaard, Hans (15) (16) (17)
Black, Corri (156)
Boerwinkle, Eric A (157) (158)
Böhm, Bernhard Otto (23) (71) (159)
Bønnelykke, Klaus (15) (16) (17)
Boomsma, D I. (27) (28)
Bottinger, Erwin P (37) (38) (160)
Canouil, Mickaël (161) (162)
Chambers, John C. (23) (41) (71)
Cheng, Ching-Y U (46) (142)
Florez, Jose Carlos (42) (44) (86)
Froguel, Philippe (23) (161) (162)
Grallert, Harald (76) (77)
Groop, Leif (73) (167)
Jonas, Jost Bruno (34) (170) (171)
Kaplan, Robert C (139) (141)
Koistinen, Heikki A (132) (176) (177)
Kovacs, Peter (95) (178)
Kutalik, Zoltán (84) (85)
Laakso, Markku H (124) (125)
Lakka, Timo Antero (123) (125) (180)
Lind, Lars (57)
Liu, Simin (21)
Palmer, Colin N A (181) (182)
Psaty, Bruce M (31) (183)
Qi, Lu (61)
Redline, Susan S (24) (44)
Ridker, Paul M (24) (44)
Saaristo, Timo E (185) (186)
Schwarz, Peter E H (76) (105) (189)
Smith, Blair Hamilton (181) (182)
Snieder, Harold (25) (26)
Sofer, Tamar (24) (44)
Sun, Liang (29)
Tai, E Shyong (39) (45) (142)
Tuomilehto, Jaakko O I (132) (167) (192)
Tusie, Teresa (64) (193)
Van Der Harst, Pim (25) (26)
Walker, Mark (195)
Wang, Ya Xing (170) (171)
Wei, Wen Bin (170) (171)
Wong, Tien-Yin (46) (142)
Yengo, Loic (161) (162) (197)
Zeggini, Eleftheria (2) (199) (200)
Zheng, Wei (60)
Gloyn, Anna Louise (11) (12) (169) (201)
Mccarthy, Mark Ian (11) (12) (202)
Meigs, James B (42) (44) (86)
Prokopenko, Inga (23) (30)
Leong, Aaron (44) (86)
Morris, Andrew Paul (11) (203) (204)
Barroso, Inês (1) (2) (101)

* Corresponding author

Affiliations

Organisations

  1. (1) University of Exeter, grid.8391.3
  2. (2) Wellcome Sanger Institute, grid.10306.34
  3. (3) University of Massachusetts Amherst, grid.266683.f
  4. (4) University of North Carolina at Chapel Hill, grid.10698.36
  5. (5) French Institute of Health and Medical Research, grid.7429.8
  6. (6) University of Michigan, grid.214458.e
  7. (7) University of Bristol, grid.5337.2
  8. (8) Institute of Metabolic Science, grid.470900.a
  9. (9) Shandong University, grid.27255.37
  10. (10) RIKEN, grid.7597.c
  11. (11) Wellcome Centre for Human Genetics, grid.270683.8
  12. (12) University of Oxford, grid.4991.5
  13. (13) Medical Research Council Human Genetics Unit, Institute for Genetics and Molecular Medicine, Edinburgh, UK
  14. (14) University of Tartu, grid.10939.32
  15. (15) Steno Diabetes Center, grid.419658.7, Capital Region
  16. (16) Gentofte Hospital, grid.411646.0, Capital Region
  17. (17) University of Copenhagen, grid.5254.6, KU
  18. (18) Boston University, grid.189504.1
  19. (19) Leiden University Medical Center, grid.10419.3d
  20. (20) City University of Hong Kong, grid.35030.35
  21. (21) Brown University, grid.40263.33
  22. (22) Harbor–UCLA Medical Center, grid.239844.0
  23. (23) Imperial College London, grid.7445.2
  24. (24) Brigham and Women's Hospital, grid.62560.37
  25. (25) University Medical Center Groningen, grid.4494.d
  26. (26) University of Groningen, grid.4830.f
  27. (27) VU University Medical Center, grid.16872.3a
  28. (28) VU Amsterdam, grid.12380.38
  29. (29) Shanghai Institute of Nutrition and Health, grid.507675.6
  30. (30) University of Surrey, grid.5475.3
  31. (31) University of Washington, grid.34477.33
  32. (32) Medical University of Graz, grid.11598.34
  33. (33) SYNLAB Academy, SYNLAB Holding Deutschland GmbH, Mannheim, Germany
  34. (34) Heidelberg University, grid.7700.0
  35. (35) Universidad Autónoma Metropolitana, grid.7220.7
  36. (36) Johns Hopkins University, grid.21107.35
  37. (37) Icahn School of Medicine at Mount Sinai, grid.59734.3c
  38. (38) Hasso Plattner Institute, grid.500266.7
  39. (39) National University of Singapore, grid.4280.e
  40. (40) University of Newcastle Australia, grid.266842.c
  41. (41) Ealing Hospital, grid.415918.0
  42. (42) Broad Institute, grid.66859.34
  43. (43) Queen Mary University of London, grid.4868.2
  44. (44) Harvard University, grid.38142.3c
  45. (45) National University Health System, grid.410759.e
  46. (46) Singapore National Eye Center, grid.419272.b
  47. (47) Institute of Biomedical Sciences, Academia Sinica, grid.482251.8
  48. (48) University of California, Los Angeles, grid.19006.3e
  49. (49) National Institute on Aging, grid.419475.a
  50. (50) National Health Research Institutes, grid.59784.37
  51. (51) Erasmus MC, grid.5645.2
  52. (52) University College London, grid.83440.3b
  53. (53) H3Africa Bioinformatics Network (H3ABioNet) Node, Centre for Genomics Research and Innovation, NABDA/FMST, Abuja, Nigeria
  54. (54) London School of Hygiene & Tropical Medicine, grid.8991.9
  55. (55) Uganda Medical Informatics Centre (UMIC), MRC/UVRI and London School of Hygiene & Tropical Medicine (Uganda Research Unit), Entebbe, Uganda
  56. (56) Bioinfosol, Sevilla, Spain
  57. (57) Uppsala University, grid.8993.b
  58. (58) University of Auckland, grid.9654.e
  59. (59) Federal University of Pelotas, grid.411221.5
  60. (60) Vanderbilt University Medical Center, grid.412807.8
  61. (61) Tulane University, grid.265219.b
  62. (62) Peking University, grid.11135.37
  63. (63) Consejo Nacional de Ciencia y Tecnología, grid.418270.8
  64. (64) Molecular Biology and Genomic Medicine Unit, National Institute of Medical Sciences and Nutrition, Mexico City, Mexico
  65. (65) Korea National Institute of Health, grid.415482.e
  66. (66) Kyoto University, grid.258799.8
  67. (67) University of Edinburgh, grid.4305.2
  68. (68) University of Colorado Anschutz Medical Campus, grid.430503.1
  69. (69) Wake Forest University, grid.241167.7
  70. (70) University of Utah, grid.223827.e
  71. (71) Nanyang Technological University, grid.59025.3b
  72. (72) University of Bergen, grid.7914.b
  73. (73) Lund University, grid.4514.4
  74. (74) NIHR Biomedical Research Centre, Guy’s and St Thomas’ Foundation Trust, London, UK
  75. (75) King's College London, grid.13097.3c
  76. (76) German Center for Diabetes Research, grid.452622.5
  77. (77) Friedrich Loeffler Institute, grid.417834.d
  78. (78) University of Maryland, Baltimore, grid.411024.2
  79. (79) Nagoya University, grid.27476.30
  80. (80) Institute for Biomedicine, Eurac Research, Bolzano, BZ, Italy
  81. (81) Institute of Genetic and Biomedical Research, grid.428485.7
  82. (82) Northwestern University, grid.16753.36
  83. (83) University of Virginia, grid.27755.32
  84. (84) Swiss Institute of Bioinformatics, grid.419765.8
  85. (85) University of Lausanne, grid.9851.5
  86. (86) Massachusetts General Hospital, grid.32224.35
  87. (87) Department of Biostatistics, University of Mitchican, Ann Arbor, MI, USA
  88. (88) Icelandic Heart Association, grid.420802.c
  89. (89) Institute of Translational Genomics, Helmholtz Zentrum München – German Research Center for Environmental Health, Institute of Translational Genomics, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany
  90. (90) University of Glasgow, grid.8756.c
  91. (91) Karolinska Institute, grid.4714.6
  92. (92) National Center For Global Health and Medicine, grid.45203.30
  93. (93) Delft University of Technology, grid.5292.c
  94. (94) Genomics plc, Oxford, UK
  95. (95) Leipzig University, grid.9647.c
  96. (96) Huazhong University of Science and Technology, grid.33199.31
  97. (97) Genome Institute of Singapore, grid.418377.e
  98. (98) University of Southern California, grid.42505.36
  99. (99) The Arctic University of Norway, grid.10919.30
  100. (100) MRC Unit for Lifelong Health and Ageing, grid.268922.5
  101. (101) University of Cambridge, grid.5335.0
  102. (102) University of Milan, grid.4708.b
  103. (103) Centro Cardiologico Monzino, grid.418230.c
  104. (104) National Human Genome Research Institute, grid.280128.1
  105. (105) TU Dresden, grid.4488.0
  106. (106) Western General Hospital, grid.417068.c
  107. (107) National Taiwan University, grid.19188.39
  108. (108) National Taiwan University Hospital, grid.412094.a
  109. (109) Harokopio University, grid.15823.3d
  110. (110) Department of Medicine Solna, Cardiovascular medicine, Stockholm, Sweden
  111. (111) Shanghai Cancer Institute, grid.419087.3
  112. (112) German Diabetes Center - Leibniz Institute for Diabetes Research at Heinrich Heine University Düsseldorf, grid.429051.b
  113. (113) Heinrich Heine University Düsseldorf, grid.411327.2
  114. (114) National Defense Medical Center, grid.260565.2
  115. (115) Tri-Service General Hospital, grid.278244.f
  116. (116) The Ohio State University Wexner Medical Center, grid.412332.5
  117. (117) Jichi Medical University, grid.410804.9
  118. (118) Ehime University, grid.255464.4
  119. (119) University of Southern Denmark, grid.10825.3e, SDU
  120. (120) City Of Hope National Medical Center, grid.410425.6
  121. (121) Osaka University, grid.136593.b
  122. (122) University of Split, grid.38603.3e
  123. (123) University of Eastern Finland, grid.9668.1
  124. (124) Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
  125. (125) Kuopio University Hospital, grid.410705.7
  126. (126) University of San Carlos, grid.267101.3
  127. (127) Renji Hospital, grid.415869.7
  128. (128) Shanghai Jiao Tong University, grid.16821.3c
  129. (129) Lifelines cohort, Groningen, The Netherlands
  130. (130) National Defense Medical Center, National Yang-Ming University, Taipei, Taiwan
  131. (131) Taichung Veterans General Hospital, grid.410764.0
  132. (132) Finnish Institute for Health and Welfare, grid.14758.3f
  133. (133) Bispebjerg Hospital, grid.411702.1, Capital Region
  134. (134) The University of Texas Health Science Center at San Antonio, grid.267309.9
  135. (135) Aichi Gakuin University, grid.411253.0
  136. (136) Shimane University, grid.411621.1
  137. (137) New York Medical College, grid.260917.b
  138. (138) Ludwig-Maximilians-Universität München, grid.5252.0
  139. (139) Albert Einstein College of Medicine, grid.251993.5
  140. (140) MSD (United States), grid.417993.1
  141. (141) Fred Hutchinson Cancer Research Center, grid.270240.3
  142. (142) Duke NUS Graduate Medical School, grid.428397.3
  143. (143) German Institute of Human Nutrition, grid.418213.d
  144. (144) Chinese National Human Genome Center at Shanghai, grid.464306.3
  145. (145) Center for Statistical Genetics, Ann Arbor, MI, USA
  146. (146) Sarepta Therapeutics (United States), grid.423097.b
  147. (147) University of Minnesota, grid.17635.36
  148. (148) Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, grid.416850.e
  149. (149) Monterrey Institute of Technology and Higher Education, grid.419886.a
  150. (150) Unidad de Investigacion de Enfermedades Metabolicas. Tec Salud, Mexico City, Mexico
  151. (151) University of Granada, grid.4489.1
  152. (152) Washington University in St. Louis, grid.4367.6
  153. (153) National Institute on Minority Health and Health Disparities, grid.281076.a
  154. (154) University of Western Australia, grid.1012.2
  155. (155) University of Cape Town, grid.7836.a
  156. (156) University of Aberdeen, grid.7107.1
  157. (157) Baylor College of Medicine, grid.39382.33
  158. (158) The University of Texas Health Science Center at Houston, grid.267308.8
  159. (159) University of Ulm, grid.6582.9
  160. (160) University of Potsdam, grid.11348.3f
  161. (161) Pasteur Institute of Lille, grid.8970.6
  162. (162) University of Lille, grid.503422.2
  163. (163) University of Mississippi Medical Center, grid.410721.1
  164. (164) University of Kelaniya, grid.45202.31
  165. (165) Istituto di Fisiologia Clinica, grid.418529.3
  166. (166) Cedars-Sinai Medical Center, grid.50956.3f
  167. (167) University of Helsinki, grid.7737.4
  168. (168) University of Iceland, grid.14013.37
  169. (169) Stanford University, grid.168010.e
  170. (170) Beijing Tongren Hospital, grid.414373.6
  171. (171) Capital Medical University, grid.24696.3f
  172. (172) Netherlands Heart Institute, grid.411737.7
  173. (173) Uganda Virus Research Institute, grid.415861.f
  174. (174) Oulu University Hospital, grid.412326.0
  175. (175) University of Oulu, grid.10858.34
  176. (176) Helsinki University Hospital, grid.15485.3d
  177. (177) Minerva Foundation, grid.452540.2
  178. (178) IFB Adiposity Diseases, grid.483476.a
  179. (179) University of Essex, grid.8356.8
  180. (180) Kuopion Liikuntalääketieteen Tutkimuslaitos, grid.419013.e
  181. (181) Ninewells Hospital, grid.416266.1
  182. (182) University of Dundee, grid.8241.f
  183. (183) Kaiser Permanente Washington Health Research Institute, grid.488833.c
  184. (184) University of California, Irvine, grid.266093.8
  185. (185) Finnish Diabetes Association, grid.478734.b
  186. (186) Pirkanmaa Hospital District, grid.415018.9
  187. (187) South Karelia Central Hospital, grid.416155.2
  188. (188) University of Miami, grid.26790.3a
  189. (189) University Hospital Carl Gustav Carus, grid.412282.f
  190. (190) Royal College of Surgeons in Ireland, grid.4912.e
  191. (191) Guy's and St Thomas' NHS Foundation Trust, grid.420545.2
  192. (192) King Abdulaziz University, grid.412125.1
  193. (193) National Autonomous University of Mexico, grid.9486.3
  194. (194) University Hospital of Lausanne, grid.8515.9
  195. (195) Newcastle University, grid.1006.7
  196. (196) Kaiser Permanente, grid.280062.e
  197. (197) University of Queensland, grid.1003.2
  198. (198) Kurume University, grid.410781.b
  199. (199) Institute of Translational Genomics, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany
  200. (200) Rechts der Isar Hospital, grid.15474.33
  201. (201) Churchill Hospital, grid.415719.f
  202. (202) NIHR Oxford Musculoskeletal Biomedical Research Centre, grid.454382.c
  203. (203) University of Liverpool, grid.10025.36
  204. (204) University of Manchester, grid.5379.8

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