selected publications
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academic article
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A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure.
American Journal of Human Genetics.
102.
2018
Aberrant intestinal microbiota in individuals with prediabetes.
Diabetologia.
61.
2018
Association of changes in inflammation with variation in glycaemia, insulin resistance and secretion based on the KORA study.
Diabetes/Metabolism Research and Reviews.
34.
2018
Circulating Fetuin-A and Risk of Type 2 Diabetes: A Mendelian Randomization Analysis.
Diabetes.
67.
2018
Consortium-based genome-wide meta-analysis for childhood dental caries traits..
Human Molecular Genetics.
27.
2018
Dairy Consumption and Body Mass Index Among Adults: Mendelian Randomization Analysis of 184802 Individuals from 25 Studies.
Clinical Chemistry.
64.
2018
Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls.
Scientific Data.
5.
2018
Interaction of Dietary and Genetic Factors Influencing Body Iron Status and Risk of Type 2 Diabetes Within the EPIC-InterAct Study.
Diabetes Care.
41.
2018
Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.
PLoS ONE.
13.
2018
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.
Nature Genetics.
50.
2018
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.
Nature Genetics.
50.
2018
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.
Nature Genetics.
50.
2018
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes.
Nature Genetics.
50.
2018
A Low-Frequency Inactivating Akt2 Variant Enriched in the Finnish Population is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk..
Diabetes.
66.
2017
A combination of plasma phospholipid fatty acids and its association with incidence of type 2 diabetes: The EPIC-InterAct case-cohort study.
PLoS Medicine.
14.
2017
An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans.
Diabetes.
66.
2017
Association between plasma phospholipid saturated fatty acids and metabolic markers of lipid, hepatic, inflammation and glycaemic pathways in eight European countries: a cross-sectional analysis in the EPIC-InterAct study.
BMC Medicine.
15.
2017
Exome-wide association study of plasma lipids in >300,000 individuals.
Nature Genetics.
49.
2017
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.
Nature Communications.
8.
2017
Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults.
PLOS Genetics.
13.
2017
Interaction between genes and macronutrient intake on the risk of developing type 2 diabetes: systematic review and findings from European Prospective Investigation into Cancer (EPIC)-InterAct..
American Journal of Clinical Nutrition.
106.
2017
Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness.
Nature Communications.
8.
2017
New Blood Pressure–Associated Loci Identified in Meta-Analyses of 475 000 Individuals.
Circulation Genomic and Precision Medicine.
10.
2017
Predicting glycated hemoglobin levels in the non-diabetic general population: Development and validation of the DIRECT-DETECT prediction model - a DIRECT study.
PLoS ONE.
12.
2017
Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions.
PLOS Genetics.
13.
2017
Rare and low-frequency coding variants alter human adult height.
Nature.
542.
2017
Sequence data and association statistics from 12,940 type 2 diabetes cases and controls.
Scientific Data.
4.
2017
Sustained influence of metformin therapy on circulating glucagon‐like peptide‐1 levels in individuals with and without type 2 diabetes.
Diabetes Obesity and Metabolism.
19.
2017
Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease.
Journal of the American College of Cardiology.
69.
2017
A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease.
Science Translational Medicine.
8.
2016
Association Between Low-Density Lipoprotein Cholesterol–Lowering Genetic Variants and Risk of Type 2 Diabetes: A Meta-analysis.
JAMA.
316.
2016
Association of Multiple Biomarkers of Iron Metabolism and Type 2 Diabetes: The EPIC-InterAct Study..
Diabetes Care.
39.
2016
Association of Plasma Phospholipid n-3 and n-6 Polyunsaturated Fatty Acids with Type 2 Diabetes: The EPIC-InterAct Case-Cohort Study.
PLoS Medicine.
13.
2016
Bicycling to Work and Primordial Prevention of Cardiovascular Risk: A Cohort Study Among Swedish Men and Women.
Journal of the American Heart Association.
5.
2016
Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease.
New England Journal of Medicine.
374.
2016
FTO genotype and weight loss: systematic review and meta-analysis of 9563 individual participant data from eight randomised controlled trials.
The BMJ.
354.
2016
Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels.
Nature Communications.
7.
2016
The genetic architecture of type 2 diabetes.
Nature.
536.
2016
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals.
Nature Genetics.
48.
2016
Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension.
Nature Genetics.
48.
2016
A Mendelian Randomization Study of Circulating Uric Acid and Type 2 Diabetes.
Diabetes.
64.
2015
Consumption of fatty foods and incident type 2 diabetes in populations from eight European countries.
European Journal of Clinical Nutrition.
69.
2015
Contribution of common non-synonymous variants in PCSK1 to body mass index variation and risk of obesity: a systematic review and meta-analysis with evidence from up to 331 175 individuals.
Human Molecular Genetics.
24.
2015
Diabetes and onset of natural menopause: results from the European Prospective Investigation into Cancer and Nutrition.
Human Reproduction.
30.
2015
Erratum. Dietary Protein Intake and Incidence of Type 2 Diabetes in Europe: The EPIC-InterAct Case-Cohort Study. Diabetes Care 2014;37:1854–1862.
Diabetes Care.
38.
2015
Examining the causal association of fasting glucose with blood pressure in healthy children and adolescents: a Mendelian randomization study employing common genetic variants of fasting glucose.
Journal of Human Hypertension.
29.
2015
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.
Nature Genetics.
47.
2015
Genetic studies of body mass index yield new insights for obesity biology.
Nature.
518.
2015
Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility.
Nature Communications.
6.
2015
New genetic loci link adipose and insulin biology to body fat distribution.
Nature.
518.
2015
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.
PLOS Genetics.
11.
2015
Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation.
Nature Genetics.
47.
2015
Common Genetic Variants Highlight the Role of Insulin Resistance and Body Fat Distribution in Type 2 Diabetes, Independent of Obesity.
Diabetes.
63.
2014
Cross‐sectional associations of objectively measured physical activity, cardiorespiratory fitness and anthropometry in European adults.
Obesity.
22.
2014
Defining the role of common variation in the genomic and biological architecture of adult human height.
Nature Genetics.
46.
2014
Dietary Intakes of Individual Flavanols and Flavonols Are Inversely Associated with Incident Type 2 Diabetes in European Populations.
Journal of Nutrition.
144.
2014
Dietary Protein Intake and Incidence of Type 2 Diabetes in Europe: The EPIC-InterAct Case-Cohort Study.
Diabetes Care.
37.
2014
Dietary vitamin D intake and risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition: the EPIC-InterAct study.
European Journal of Clinical Nutrition.
68.
2014
Differences in the prospective association between individual plasma phospholipid saturated fatty acids and incident type 2 diabetes: the EPIC-InterAct case-cohort study.
The Lancet Diabetes & Endocrinology.
2.
2014
Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: rationale and design of the epidemiological studies within the IMI DIRECT Consortium.
Diabetologia.
57.
2014
FTO genetic variants, dietary intake and body mass index: insights from 177 330 individuals.
Human Molecular Genetics.
23.
2014
Gene-Lifestyle Interaction and Type 2 Diabetes: The EPIC InterAct Case-Cohort Study.
PLoS Medicine.
11.
2014
Lifestyle factors and mortality risk in individuals with diabetes mellitus: are the associations different from those in individuals without diabetes?.
Diabetologia.
57.
2014
Non-invasive risk scores for prediction of type 2 diabetes (EPIC-InterAct): a validation of existing models.
The Lancet Diabetes & Endocrinology.
2.
2014
Smoking and Long-Term Risk of Type 2 Diabetes: The EPIC-InterAct Study in European Populations.
Diabetes Care.
37.
2014
Validity of Electronically Administered Recent Physical Activity Questionnaire (RPAQ) in Ten European Countries.
PLoS ONE.
9.
2014
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chapter
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Gene-Physical Activity Interactions and Their Impact on Diabetes.
Karger Publishers.
2014
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dataset
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Novel SNVs/Genes associated with BP traits from correlated meta-analysis in European ancestry in Stage 1..
public-library-of-science.
2018
Novel SNVs/Genes associated with BP traits in European ancestry..
public-library-of-science.
2018
Novel SNVs/Genes associated with BP traits in European ancestry..
public-library-of-science.
2018
Novel SNVs/Genes associated with BP traits in Multi-ancestry meta-analysis in combined Stage 1 and Stage 2..
public-library-of-science.
2018
Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.
public-library-of-science.
2018
Potential novel SNVs/Genes associated with BP traits in African ancestry..
public-library-of-science.
2018
A combination of plasma phospholipid fatty acids and its association with incidence of type 2 diabetes: The EPIC-InterAct case-cohort study.
public-library-of-science.
2017
Association of the fatty acid pattern score with incidence of type 2 diabetes: EPIC -InterAct (n = 27,296)..
public-library-of-science.
2017
Associations of the fatty acid pattern score with metabolic factors in EPIC-InterAct and with metabolic factors in the US NHANES 2003–2004..
public-library-of-science.
2017
Baseline characteristics of the 4 datasets..
public-library-of-science.
2017
Comparison of Levene's test Pv ranks from different centiles of the Pm rank-ordered distribution for the index traits..
public-library-of-science.
2017
Comparison of marginal effects Pm ranks from different centiles of the Levene's test Pv rank-ordered distribution for the index traits..
public-library-of-science.
2017
Discriminative performance after internal validation a..
public-library-of-science.
2017
Enrichment of SNPs with nominally significant Pint for test of SNP × Smoking and SNP × Physical Activity interaction for BMI (Pint<0.05) by SNPs with nominally significant Levene's test (Pv<0.05)..
public-library-of-science.
2017
Enrichment of variance and gene × environment interaction nominally significant results with GWAS-derived loci..
public-library-of-science.
2017
Explained variance after internal validation..
public-library-of-science.
2017
Genes of biological interest within 500 kb of lead SNPs associated with BMI..
public-library-of-science.
2017
Genes of biological interest within 500 kb of lead SNPs associated with WCadjBMI or WHRadjBMI..
public-library-of-science.
2017
Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults.
public-library-of-science.
2017
Levenes test P values.
dryad.
2017
Linear regression model predicting HbA1c levels after 6 years..
public-library-of-science.
2017
Novel loci achieving genome-wide significance (P<5x10-8) in meta-analyses for PA-adjusted SNP main effect (PadjPA) or the joint test of SNP main effect and SNP-PA interaction (Pjoint)..
public-library-of-science.
2017
Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions.
public-library-of-science.
2017
Relative concentrations of plasma phospholipid fatty acids and their correlations with the identified fatty acid pattern score: EPIC-InterAct sub-cohort (n = 15,919)..
public-library-of-science.
2017
Spearman correlations between Pint in SNP × Physical Activity and SNP × Smoking on BMI analyses and marginal effects Pm or heterogeneity of variance from Levene's test Pv..
public-library-of-science.
2017
Spearman correlations between marginal effects Pm and heterogeneity of variance from Levene's test Pv..
public-library-of-science.
2017
Association of Plasma Phospholipid n-3 and n-6 Polyunsaturated Fatty Acids with Type 2 Diabetes: The EPIC-InterAct Case-Cohort Study.
public-library-of-science.
2016
Results for associations of circulating n-3 and n-6 PUFAs and fatty acid ratios with incidence of T2D: EPIC-InterAct study and comparative meta-analysis of the published prospective studies*..
public-library-of-science.
2016
The distribution of sociodemographic and dietary factors at baseline by future case and noncase status: EPIC-InterAct study..
public-library-of-science.
2016
Enrichment analyses using look-up data for the 15 age-group specific BMI loci..
public-library-of-science.
2015
Fifteen BMI loci showing significant age-differences in adults ≤50y compared to adults >50y..
public-library-of-science.
2015
Forty-four WHRadjBMI loci showing significant sex-differences..
public-library-of-science.
2015
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.
public-library-of-science.
2015
Baseline characteristics of the random sub-cohort participants in the InterAct study..
public-library-of-science.
2014
Domain-specific energy expenditure from the RPAQ and partial correlation with objectively assessed physical activity energy expenditure adjusted for all other domains (580 men and 1343 women)..
public-library-of-science.
2014
Gene-Lifestyle Interaction and Type 2 Diabetes: The EPIC InterAct Case-Cohort Study.
public-library-of-science.
2014
Hazard ratios for type 2 diabetes per risk allele for each of 49 SNPs and per standard deviation for additive genetic scores, adjusted for sex and centre: the InterAct study..
public-library-of-science.
2014
Participant characteristics at baseline, the RPAQ validation study cohort (N = 1923)..
public-library-of-science.
2014
Physical activity energy expenditure (kJ/kg/day) as assessed by the Recent Physical Activity Questionnaire and combined movement sensor and heart rate monitor, N = 1923..
public-library-of-science.
2014
Time spent in moderate and vigorous physical activity (min/day) as assessed by the Recent Physical Activity Questionnaire and combined movement sensor and heart rate monitor, N = 1923..
public-library-of-science.
2014
Time spent sedentary (h/day) as assessed by the Recent Physical Activity Questionnaire and combined movement sensor and heart rate monitor, N = 1923..
public-library-of-science.
2014
Validity of Electronically Administered Recent Physical Activity Questionnaire (RPAQ) in Ten European Countries.
public-library-of-science.
2014
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hide from search
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Association of the genetic risk score with BMI and risk of obesity adjusted for age, age2, and sex in the combined sample of all 11 cohorts and further stratified by physical activity level..
public-library-of-science.
2013
Baseline Characteristics a of 4,516 Individuals with Diabetes Mellitus from the European Prospective Investigation into Cancer and Nutrition by Type of Medication Use..
public-library-of-science.
2013
Baseline Characteristicsa of 4,345 Individuals with Diabetes from the European Prospective Investigation into Cancer and Nutrition across Study Center-Specific Quartiles of HbA1c Measured in Stored Erythrocytes..
public-library-of-science.
2013
Gene × Physical Activity Interactions in Obesity: Combined Analysis of 111,421 Individuals of European Ancestry.
public-library-of-science.
2013
Hazard Ratios (95% CI) of Associations Between a 1% -Increase in HbA1c and Total Mortality, Stratified for Several Diabetes-Related Variables, and Cause-Specific Mortality in 4,345 Individuals with Diabetes Mellitus..
public-library-of-science.
2013
Hazard Ratios (95% CI) of Associations between HbA1c, Diabetes Medication use, Disease Duration and Total Mortality in Individuals with Diabetes..
public-library-of-science.
2013
Meta-analyzed single SNP interactions with physical activity* on BMI..
public-library-of-science.
2013
Age at Menarche and Type 2 Diabetes Risk.
Diabetes Care.
2013
Age at Menopause, Reproductive Life Span, and Type 2 Diabetes Risk Results from the EPIC-InterAct study.
Diabetes Care.
2013
Common variants associated with plasma triglycerides and risk for coronary artery disease.
Nature Genetics.
2013
Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes.
Diabetologia.
2013
Gene × Physical Activity Interactions in Obesity: Combined Analysis of 111,421 Individuals of European Ancestry.
PLOS Genetics.
2013
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
Nature Genetics.
2013
Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits.
PLOS Genetics.
2013
The Association Between Dietary Flavonoid and Lignan Intakes and Incident Type 2 Diabetes in European Populations The EPIC-InterAct study.
Diabetes Care.
2013
The Association between Dietary Energy Density and Type 2 Diabetes in Europe: Results from the EPIC-InterAct Study.
PLoS ONE.
2013
Association of the minor (A−) allele of the rs9939609 SNP or a proxy (r2>0.8) in the FTO gene with BMI, waist circumference, body fat percentage, risk of obesity, and risk of overweight in a random effects meta-analysis of up to 218,166 adults..
public-library-of-science.
2011
Effect of the interaction between the rs9939609 SNP or a proxy (r2>0.8) and PA on BMI, waist circumference, body fat percentage, risk of obesity, and risk of overweight in a random effects meta-analysis of up to 218,166 adults..
public-library-of-science.
2011
Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children.
public-library-of-science.
2011
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preprint