selected publications
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academic article
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A de novo Ser111Thr variant in aquaporin-4 in a patient with intellectual disability, transient signs of brain ischemia, transient cardiac hypertrophy, and progressive gait disturbance.
Molecular Case Studies.
4.
2018
Author Correction: The thiazide sensitive sodium chloride co-transporter NCC is modulated by site-specific ubiquitylation.
Scientific Reports.
8.
2018
Azosemide is more potent than bumetanide and various other loop diuretics to inhibit the sodium-potassium-chloride-cotransporter human variants hNKCC1A and hNKCC1B.
Scientific Reports.
8.
2018
Bumepamine, a brain-permeant benzylamine derivative of bumetanide, does not inhibit NKCC1 but is more potent to enhance phenobarbital’s anti-seizure efficacy.
Neuropharmacology.
143.
2018
Cerebral influx of Na+ and Cl− as the osmotherapy-mediated rebound response in rats.
Fluids and Barriers of the CNS.
15.
2018
Cotransporter-mediated water transport underlying cerebrospinal fluid formation.
Nature Communications.
9.
2018
Sensing and regulation of cell volume – we know so much and yet understand so little: TRPV4 as a sensor of volume changes but possibly without a volume-regulatory role?.
Channels.
12.
2018
Targeted deletion of the aquaglyceroporin AQP9 is protective in a mouse model of Parkinson’s disease.
PLoS ONE.
13.
2018
Activity‐dependent astrocyte swelling is mediated by pH‐regulating mechanisms.
Glia.
65.
2017
Connexin Hemichannels in Astrocytes: An Assessment of Controversies Regarding Their Functional Characteristics.
Neurochemical Research.
42.
2017
Functional assessment of sodium chloride cotransporter NCC mutants in polarized mammalian epithelial cells.
American Journal of Physiology. Renal physiology.
313.
2017
Permeant-specific gating of connexin 30 hemichannels.
Journal of Biological Chemistry.
292.
2017
The thiazide sensitive sodium chloride co-transporter NCC is modulated by site-specific ubiquitylation.
Scientific Reports.
7.
2017
The α2β2 isoform combination dominates the astrocytic Na+/K+‐ATPase activity and is rendered nonfunctional by the α2.G301R familial hemiplegic migraine type 2‐associated mutation.
Glia.
65.
2017
When size matters: transient receptor potential vanilloid 4 channel as a volume‐sensor rather than an osmo‐sensor.
The Journal of Physiology.
595.
2017
Aquaporin 4 as a NH3 Channel.
Journal of Biological Chemistry.
291.
2016
Autoantibodies Targeting a Collecting Duct–Specific Water Channel in Tubulointerstitial Nephritis.
Journal of the American Society of Nephrology.
27.
2016
Cl− channels in apoptosis.
European Biophysics Journal.
45.
2016
Glutamate transporter activity promotes enhanced Na+/K+‐ATPase‐mediated extracellular K+ management during neuronal activity.
The Journal of Physiology.
594.
2016
Managing Brain Extracellular K+ during Neuronal Activity: The Physiological Role of the Na+/K+-ATPase Subunit Isoforms.
Frontiers in Physiology.
7.
2016
Regulation of the Water Channel Aquaporin-2 via 14-3-3θ and -ζ.
Journal of Biological Chemistry.
291.
2016
The search for NKCC1-selective drugs for the treatment of epilepsy: Structure–function relationship of bumetanide and various bumetanide derivatives in inhibiting the human cation-chloride cotransporter NKCC1A.
Epilepsy & Behavior.
59.
2016
The vasopressin type 2 receptor and prostaglandin receptors EP2 and EP4 can increase aquaporin-2 plasma membrane targeting through a cAMP-independent pathway..
American Journal of Physiology. Renal physiology.
311.
2016
Chloride Cotransporters as a Molecular Mechanism underlying Spreading Depolarization-Induced Dendritic Beading.
Journal of Neuroscience.
35.
2015
H95 Is a pH-Dependent Gate in Aquaporin 4.
Structure.
23.
2015
Isoform-specific phosphorylation-dependent regulation of connexin hemichannels.
Journal of Neurophysiology.
114.
2015
PKC and AMPK regulation of Kv1.5 potassium channels.
Channels.
9.
2015
Protein kinase C-dependent regulation of connexin43 gap junctions and hemichannels..
Biochemical Society Transactions.
43.
2015
Regulation and Function of AQP4 in the Central Nervous System.
Neurochemical Research.
40.
2015
Structure–activity relationships of bumetanide derivatives: correlation between diuretic activity in dogs and inhibition of the human NKCC2A transporter.
British Journal of Pharmacology.
172.
2015
TRPV4 and AQP4 Channels Synergistically Regulate Cell Volume and Calcium Homeostasis in Retinal Müller Glia.
Journal of Neuroscience.
35.
2015
Vasopressin receptors V1a and V2 are not osmosensors.
Physiological Reports.
3.
2015
AQP4 plasma membrane trafficking or channel gating is not significantly modulated by phosphorylation at COOH-terminal serine residues.
American Journal of Physiology - Cell Physiology.
307.
2014
Activation, Permeability, and Inhibition of Astrocytic and Neuronal Large Pore (Hemi)channels.
Journal of Biological Chemistry.
289.
2014
Contributions of the Na+/K+‐ATPase, NKCC1, and Kir4.1 to hippocampal K+ clearance and volume responses.
Glia.
62.
2014
Distinct permeation profiles of the connexin 30 and 43 hemichannels.
FEBS Letters.
588.
2014
Kir4.1-mediated spatial buffering of K+: Experimental challenges in determination of its temporal and quantitative contribution to K+ clearance in the brain.
Channels.
8.
2014
Swelling and Eicosanoid Metabolites Differentially Gate TRPV4 Channels in Retinal Neurons and Glia.
Journal of Neuroscience.
34.
2014
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dataset
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Targeted deletion of the aquaglyceroporin AQP9 is protective in a mouse model of Parkinson’s disease.
public-library-of-science.
2018
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Functional Modulation of the Glutamate Transporter Variant GLT1b by the PDZ Domain Protein PICK1.
Journal of Biological Chemistry.
2013
Osmotic water transport in aquaporins: evidence for a stochastic mechanism.
The Journal of Physiology.
2013
Phosphorylation of rat aquaporin‐4 at Ser111 is not required for channel gating.
Glia.
2013