Holm, René

Challenges and trends in apomorphine drug delivery systems for the treatment of Parkinson's disease

Comparison of two DSC-based methods to predict drug-polymer solubility

Effect of amorphous phase separation and crystallization on the in vitro and in vivo performance of an amorphous solid dispersion

Exploring gastric emptying rate in mini-pigs: Effect of food type and pre-dosing of metoclopramide

Injectable anti-malarials revisited: discovery and development of new agents to protect against malaria

Montmorillonite and Laponite Clay Materials for the Solidification of Lipid-Based Formulations for the Basic Drug Blonanserin: In Vitro and in Vivo Investigations.

Nonionic surfactants increase digoxin absorption in Caco-2 and MDCKII MDR1 cells: Impact on P-glycoprotein inhibition, barrier function, and repeated cellular exposure

Polysorbate 20 alters the oral bioavailability of etoposide in wild type and mdr1a deficient Sprague-Dawley rats

Solid lipid nanocarriers in drug delivery: characterization and design

Amorphization within the tablet: Using microwave irradiation to form a glass solution in situ

Efficacy of oral lipid‐based formulations of apomorphine and its diester in a Parkinson's disease rat model

Importance of in vitro dissolution conditions for the in vivo predictability of an amorphous solid dispersion containing a pH-sensitive carrier

Investigation of the Intra- and Interlaboratory Reproducibility of a Small Scale Standardized Supersaturation and Precipitation Method.

Oral and intravenous pharmacokinetics of taurine in sprague‐dawley rats: the influence of dose and the possible involvement of the proton‐coupled amino acid transporter, PAT1, in oral taurine absorption

Simultaneous lipolysis/permeation in vitro model, for the estimation of bioavailability of lipid based drug delivery systems

Soluble 1:1 complexes and insoluble 3:2 complexes – Understanding the phase-solubility diagram of hydrocortisone and γ-cyclodextrin

Solution or suspension – Does it matter for lipid based systems? In vivo studies of chase dosing lipid vehicles with aqueous suspensions of a poorly soluble drug

A Promising New Method to Estimate Drug-Polymer Solubility at Room Temperature

A Transporter of Ibuprofen is Upregulated in MDCK I Cells under Hyperosmotic Culture Conditions.

A heuristic model to quantify the impact of excess cyclodextrin on oral drug absorption from aqueous solution

Apomorphine and its esters: Differences in Caco-2 cell permeability and chylomicron affinity

Buccal absorption of diazepam is improved when administered in bioadhesive tablets—An in vivo study in conscious Göttingen mini-pigs

Development of a μDissolution-Permeation model with in situ drug concentration monitoring

Displacement of Drugs from Cyclodextrin Complexes by Bile Salts: A Suggestion of an Intestinal Drug‐Solubilizing Capacity from an In Vitro Model

Dissolution Model Development: Formulation Effects and Filter Complications

Does the Digestibility of Cyclodextrins Influence the In Vivo Absorption of Benzo[a]pyrene in Rats?

Effect of cyclodextrin concentration on the oral bioavailability of danazol and cinnarizine in rats

Effect of food intake and co-administration of placebo self-nanoemulsifying drug delivery systems on the absorption of cinnarizine in healthy human volunteers

Effect of polymer type and drug dose on the in vitro and in vivo behavior of amorphous solid dispersions

Glass solution formation in water - In situ amorphization of naproxen and ibuprofen with Eudragit® E PO

Hydration Differences Explain the Large Variations in the Complexation Thermodynamics of Modified γ-Cyclodextrins with Bile Salts.

Ibuprofen transport in renal cell cultures: characterization of an ibuprofen transporter upregulated by hyperosmolarity

In vivo evaluation of lipid-based formulations for oral delivery of apomorphine and its diester prodrugs

Influence of Copolymer Composition on In Vitro and In Vivo Performance of Celecoxib-PVP/VA Amorphous Solid Dispersions

Influence of PVP/VA copolymer composition on drug–polymer solubility

Influence of polymer molecular weight on in vitro dissolution behavior and in vivo performance of celecoxib:PVP amorphous solid dispersions

Interaction of GABA-mimetics with the taurine transporter (TauT, Slc6a6) in hyperosmotic treated Caco-2, LLC-PK1 and rat renal SKPT cells

Interlaboratory Validation of Small-Scale Solubility and Dissolution Measurements of Poorly Water-Soluble Drugs

Investigation of surface porosity measurements and compaction pressure as means to ensure consistent contact angle determinations

Pharmacokinetic/Pharmacodynamic Relationship of Gabapentin in a CFA-induced Inflammatory Hyperalgesia Rat Model

Polysorbate 20 increases oral absorption of digoxin in wild-type Sprague Dawley rats, but not in mdr1a(-/-) Sprague Dawley rats

Quantitative surface topography assessment of directly compressed and roller compacted tablet cores using photometric stereo image analysis

Recent advances and potential applications of modulated differential scanning calorimetry (mDSC) in drug development

Statistical Analysis of a Method to Predict Drug–Polymer Miscibility

Thermodynamic investigation of the interaction between cyclodextrins and preservatives — Application and verification in a mathematical model to determine the needed preservative surplus in aqueous cyclodextrin formulations

Transferrin receptor expression and role in transendothelial transport of transferrin in cultured brain endothelial monolayers

Tween 20 increases intestinal transport of doxorubicin in vitro but not in vivo

Use of Permeapad® for prediction of buccal absorption: A comparison to in vitro, ex vivo and in vivo method

Comparative Study of Different Methods for the Prediction of Drug-Polymer Solubility.

Determination of thermodynamic potentials and the aggregation number for micelles with the mass-action model by isothermal titration calorimetry: A case study on bile salts

Evaluation of Drug–Polymer Solubility Curves Through Formal Statistical Analysis: Comparison of Preparation Techniques

Evaluation of the Use of Göttingen Minipigs to Predict Food Effects on the Oral Absorption of Drugs in Humans

In vivo and In vitro Evaluations of Intestinal Gabapentin Absorption: Effect of Dose and Inhibitors on Carrier-Mediated Transport

Influence of Polymer Molecular Weight on Drug–Polymer Solubility: A Comparison between Experimentally Determined Solubility in PVP and Prediction Derived from Solubility in Monomer

Investigation of enzyme-sensitive lipid nanoparticles for delivery of siRNA to blood–brain barrier and glioma cells

Is oral absorption of vigabatrin carrier-mediated?

Kolliphor surfactants affect solubilization and bioavailability of fenofibrate. Studies of in vitro digestion and absorption in rats.

Lipophilic prodrugs of apomorphine I: Preparation, characterisation, and in vitro enzymatic hydrolysis in biorelevant media

Permeapad™ for investigation of passive drug permeability: The effect of surfactants, co-solvents and simulated intestinal fluids (FaSSIF and FeSSIF)

A study of salt effects on the complexation between β-cyclodextrins and bile salts based on the Hofmeister series

Azone® Decreases the Buccal Mucosal Permeation of Diazepam in a Concentration‐Dependent Manner via a Reservoir Effect

Cinnarizine food-effects in beagle dogs can be avoided by administration in a Self Nano Emulsifying Drug Delivery System (SNEDDS)

Combining in vitro and in silico methods for better prediction of surfactant effects on the absorption of poorly water soluble drugs—a fenofibrate case example

Complexation thermodynamics of modified cyclodextrins: extended cavities and distorted structures.

Computational investigation of enthalpy-entropy compensation in complexation of glycoconjugated bile salts with β-cyclodextrin and analogs.

Conscious and anaesthetised Göttingen mini-pigs as an in-vivo model for buccal absorption – pH-dependent absorption of metoprolol from bioadhesive tablets

Determination of stability constants of tauro- and glyco-conjugated bile salts with the negatively charged sulfobutylether-β-cyclodextrin: comparison of affinity capillary electrophoresis and isothermal titration calorimetry and thermodynamic analysis of the interaction

Determination of the aggregation number for micelles by isothermal titration calorimetry

Early pharmaceutical profiling to predict oral drug absorption: Current status and unmet needs

Ex Vivo Correlation of the Permeability of Metoprolol Across Human and Porcine Buccal Mucosa

Extending the hydrophobic cavity of β-cyclodextrin results in more negative heat capacity changes but reduced binding affinities

Fed and fasted state gastro-intestinal in vitro lipolysis: In vitro in vivo relations of a conventional tablet, a SNEDDS and a solidified SNEDDS

In Vitro Lipolysis Data Does Not Adequately Predict the In Vivo Performance of Lipid-Based Drug Delivery Systems Containing Fenofibrate

In vitro models for the prediction of in vivo performance of oral dosage forms

Intestinal absorption of the antiepileptic drug substance vigabatrin in Göttingen mini-pigs is unaffected by co-administration of amino acids

Intestinal absorption of the antiepileptic drug substance vigabatrin is altered by infant formula in vitro and in vivo.

Investigating the correlation between in vivo absorption and in vitro release of fenofibrate from lipid matrix particles in biorelevant medium

PAT1 (SLC36A1) shows nuclear localization and affects growth of smooth muscle cells from rats

The absorptive flux of the anti-epileptic drug substance vigabatrin is carrier-mediated across Caco-2 cell monolayers

The anti-epileptic drug substance vigabatrin inhibits taurine transport in intestinal and renal cell culture models

NORA - National Open Research Analytics

A prototype built with Dimensions data 2014-2019 and open tools — more

Holm, René

Positions

Publications

selected publications

academic article

hide from search

Contact

full name