selected publications
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academic article
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Challenges and trends in apomorphine drug delivery systems for the treatment of Parkinson's disease.
Asian Journal of Pharmaceutical Sciences.
13.
2018
Comparison of two DSC-based methods to predict drug-polymer solubility.
International Journal of Pharmaceutics.
540.
2018
Effect of amorphous phase separation and crystallization on the in vitro and in vivo performance of an amorphous solid dispersion.
European Journal of Pharmaceutics and Biopharmaceutics.
130.
2018
Exploring gastric emptying rate in mini-pigs: Effect of food type and pre-dosing of metoclopramide.
European Journal of Pharmaceutical Sciences.
118.
2018
Injectable anti-malarials revisited: discovery and development of new agents to protect against malaria.
Malaria Journal.
17.
2018
Montmorillonite and Laponite Clay Materials for the Solidification of Lipid-Based Formulations for the Basic Drug Blonanserin: In Vitro and in Vivo Investigations..
Molecular Pharmaceutics.
15.
2018
Nonionic surfactants increase digoxin absorption in Caco-2 and MDCKII MDR1 cells: Impact on P-glycoprotein inhibition, barrier function, and repeated cellular exposure.
International Journal of Pharmaceutics.
551.
2018
Polysorbate 20 alters the oral bioavailability of etoposide in wild type and mdr1a deficient Sprague-Dawley rats.
International Journal of Pharmaceutics.
543.
2018
Solid lipid nanocarriers in drug delivery: characterization and design.
Expert Opinion on Drug Delivery.
15.
2018
Amorphization within the tablet: Using microwave irradiation to form a glass solution in situ.
International Journal of Pharmaceutics.
519.
2017
Efficacy of oral lipid‐based formulations of apomorphine and its diester in a Parkinson's disease rat model.
Journal of Pharmacy and Pharmacology.
69.
2017
Importance of in vitro dissolution conditions for the in vivo predictability of an amorphous solid dispersion containing a pH-sensitive carrier.
International Journal of Pharmaceutics.
531.
2017
Investigation of the Intra- and Interlaboratory Reproducibility of a Small Scale Standardized Supersaturation and Precipitation Method..
Molecular Pharmaceutics.
14.
2017
Oral and intravenous pharmacokinetics of taurine in sprague‐dawley rats: the influence of dose and the possible involvement of the proton‐coupled amino acid transporter, PAT1, in oral taurine absorption.
Physiological Reports.
5.
2017
Simultaneous lipolysis/permeation in vitro model, for the estimation of bioavailability of lipid based drug delivery systems.
European Journal of Pharmaceutics and Biopharmaceutics.
117.
2017
Soluble 1:1 complexes and insoluble 3:2 complexes – Understanding the phase-solubility diagram of hydrocortisone and γ-cyclodextrin.
International Journal of Pharmaceutics.
531.
2017
Solution or suspension – Does it matter for lipid based systems? In vivo studies of chase dosing lipid vehicles with aqueous suspensions of a poorly soluble drug.
European Journal of Pharmaceutics and Biopharmaceutics.
117.
2017
A Promising New Method to Estimate Drug-Polymer Solubility at Room Temperature.
Journal of Pharmaceutical Sciences.
105.
2016
A Transporter of Ibuprofen is Upregulated in MDCK I Cells under Hyperosmotic Culture Conditions..
Molecular Pharmaceutics.
13.
2016
A heuristic model to quantify the impact of excess cyclodextrin on oral drug absorption from aqueous solution.
European Journal of Pharmaceutics and Biopharmaceutics.
102.
2016
Apomorphine and its esters: Differences in Caco-2 cell permeability and chylomicron affinity.
International Journal of Pharmaceutics.
509.
2016
Buccal absorption of diazepam is improved when administered in bioadhesive tablets—An in vivo study in conscious Göttingen mini-pigs.
International Journal of Pharmaceutics.
515.
2016
Development of a μDissolution-Permeation model with in situ drug concentration monitoring.
Journal of Drug Delivery Science and Technology.
35.
2016
Displacement of Drugs from Cyclodextrin Complexes by Bile Salts: A Suggestion of an Intestinal Drug‐Solubilizing Capacity from an In Vitro Model.
Journal of Pharmaceutical Sciences.
105.
2016
Dissolution Model Development: Formulation Effects and Filter Complications.
Dissolution Technologies.
23.
2016
Does the Digestibility of Cyclodextrins Influence the In Vivo Absorption of Benzo[a]pyrene in Rats?.
Journal of Pharmaceutical Sciences.
105.
2016
Effect of cyclodextrin concentration on the oral bioavailability of danazol and cinnarizine in rats.
European Journal of Pharmaceutics and Biopharmaceutics.
101.
2016
Effect of food intake and co-administration of placebo self-nanoemulsifying drug delivery systems on the absorption of cinnarizine in healthy human volunteers.
European Journal of Pharmaceutical Sciences.
84.
2016
Effect of polymer type and drug dose on the in vitro and in vivo behavior of amorphous solid dispersions.
European Journal of Pharmaceutics and Biopharmaceutics.
105.
2016
Glass solution formation in water - In situ amorphization of naproxen and ibuprofen with Eudragit® E PO.
Journal of Drug Delivery Science and Technology.
34.
2016
Hydration Differences Explain the Large Variations in the Complexation Thermodynamics of Modified γ-Cyclodextrins with Bile Salts..
The Journal of Physical Chemistry B.
120.
2016
Ibuprofen transport in renal cell cultures: characterization of an ibuprofen transporter upregulated by hyperosmolarity.
MedChemComm.
7.
2016
In vivo evaluation of lipid-based formulations for oral delivery of apomorphine and its diester prodrugs.
International Journal of Pharmaceutics.
513.
2016
Influence of Copolymer Composition on In Vitro and In Vivo Performance of Celecoxib-PVP/VA Amorphous Solid Dispersions.
The AAPS Journal.
18.
2016
Influence of PVP/VA copolymer composition on drug–polymer solubility.
European Journal of Pharmaceutical Sciences.
85.
2016
Influence of polymer molecular weight on in vitro dissolution behavior and in vivo performance of celecoxib:PVP amorphous solid dispersions.
European Journal of Pharmaceutics and Biopharmaceutics.
101.
2016
Interaction of GABA-mimetics with the taurine transporter (TauT, Slc6a6) in hyperosmotic treated Caco-2, LLC-PK1 and rat renal SKPT cells.
European Journal of Pharmaceutical Sciences.
82.
2016
Interlaboratory Validation of Small-Scale Solubility and Dissolution Measurements of Poorly Water-Soluble Drugs.
Journal of Pharmaceutical Sciences.
105.
2016
Investigation of surface porosity measurements and compaction pressure as means to ensure consistent contact angle determinations.
International Journal of Pharmaceutics.
498.
2016
Pharmacokinetic/Pharmacodynamic Relationship of Gabapentin in a CFA-induced Inflammatory Hyperalgesia Rat Model.
Pharmaceutical Research.
33.
2016
Polysorbate 20 increases oral absorption of digoxin in wild-type Sprague Dawley rats, but not in mdr1a(-/-) Sprague Dawley rats.
International Journal of Pharmaceutics.
513.
2016
Quantitative surface topography assessment of directly compressed and roller compacted tablet cores using photometric stereo image analysis.
European Journal of Pharmaceutical Sciences.
87.
2016
Recent advances and potential applications of modulated differential scanning calorimetry (mDSC) in drug development.
European Journal of Pharmaceutical Sciences.
87.
2016
Statistical Analysis of a Method to Predict Drug–Polymer Miscibility.
Journal of Pharmaceutical Sciences.
105.
2016
Thermodynamic investigation of the interaction between cyclodextrins and preservatives — Application and verification in a mathematical model to determine the needed preservative surplus in aqueous cyclodextrin formulations.
European Journal of Pharmaceutical Sciences.
87.
2016
Transferrin receptor expression and role in transendothelial transport of transferrin in cultured brain endothelial monolayers.
Molecular and Cellular Neuroscience.
76.
2016
Tween 20 increases intestinal transport of doxorubicin in vitro but not in vivo.
International Journal of Pharmaceutics.
498.
2016
Use of Permeapad® for prediction of buccal absorption: A comparison to in vitro, ex vivo and in vivo method.
European Journal of Pharmaceutical Sciences.
93.
2016
Comparative Study of Different Methods for the Prediction of Drug-Polymer Solubility..
Molecular Pharmaceutics.
12.
2015
Determination of thermodynamic potentials and the aggregation number for micelles with the mass-action model by isothermal titration calorimetry: A case study on bile salts.
Journal of Colloid and Interface Science.
453.
2015
Evaluation of Drug–Polymer Solubility Curves Through Formal Statistical Analysis: Comparison of Preparation Techniques.
Journal of Pharmaceutical Sciences.
104.
2015
Evaluation of the Use of Göttingen Minipigs to Predict Food Effects on the Oral Absorption of Drugs in Humans.
Journal of Pharmaceutical Sciences.
104.
2015
In vivo and In vitro Evaluations of Intestinal Gabapentin Absorption: Effect of Dose and Inhibitors on Carrier-Mediated Transport.
Pharmaceutical Research.
32.
2015
Influence of Polymer Molecular Weight on Drug–Polymer Solubility: A Comparison between Experimentally Determined Solubility in PVP and Prediction Derived from Solubility in Monomer.
Journal of Pharmaceutical Sciences.
104.
2015
Investigation of enzyme-sensitive lipid nanoparticles for delivery of siRNA to blood–brain barrier and glioma cells.
International Journal of Nanomedicine.
Volume 10.
2015
Is oral absorption of vigabatrin carrier-mediated?.
European Journal of Pharmaceutical Sciences.
69.
2015
Kolliphor surfactants affect solubilization and bioavailability of fenofibrate. Studies of in vitro digestion and absorption in rats..
Molecular Pharmaceutics.
12.
2015
Lipophilic prodrugs of apomorphine I: Preparation, characterisation, and in vitro enzymatic hydrolysis in biorelevant media.
European Journal of Pharmaceutics and Biopharmaceutics.
89.
2015
Permeapad™ for investigation of passive drug permeability: The effect of surfactants, co-solvents and simulated intestinal fluids (FaSSIF and FeSSIF).
International Journal of Pharmaceutics.
493.
2015
A study of salt effects on the complexation between β-cyclodextrins and bile salts based on the Hofmeister series.
Journal of Inclusion Phenomena and Macrocyclic Chemistry.
80.
2014
Azone® Decreases the Buccal Mucosal Permeation of Diazepam in a Concentration‐Dependent Manner via a Reservoir Effect.
Journal of Pharmaceutical Sciences.
103.
2014
Cinnarizine food-effects in beagle dogs can be avoided by administration in a Self Nano Emulsifying Drug Delivery System (SNEDDS).
European Journal of Pharmaceutical Sciences.
57.
2014
Combining in vitro and in silico methods for better prediction of surfactant effects on the absorption of poorly water soluble drugs—a fenofibrate case example.
International Journal of Pharmaceutics.
473.
2014
Complexation thermodynamics of modified cyclodextrins: extended cavities and distorted structures..
The Journal of Physical Chemistry B.
118.
2014
Computational investigation of enthalpy-entropy compensation in complexation of glycoconjugated bile salts with β-cyclodextrin and analogs..
The Journal of Physical Chemistry B.
118.
2014
Conscious and anaesthetised Göttingen mini-pigs as an in-vivo model for buccal absorption – pH-dependent absorption of metoprolol from bioadhesive tablets.
Drug Development and Industrial Pharmacy.
40.
2014
Determination of stability constants of tauro- and glyco-conjugated bile salts with the negatively charged sulfobutylether-β-cyclodextrin: comparison of affinity capillary electrophoresis and isothermal titration calorimetry and thermodynamic analysis of the interaction.
Journal of Inclusion Phenomena and Macrocyclic Chemistry.
78.
2014
Determination of the aggregation number for micelles by isothermal titration calorimetry.
Thermochimica Acta.
588.
2014
Early pharmaceutical profiling to predict oral drug absorption: Current status and unmet needs.
European Journal of Pharmaceutical Sciences.
57.
2014
Ex Vivo Correlation of the Permeability of Metoprolol Across Human and Porcine Buccal Mucosa.
Journal of Pharmaceutical Sciences.
103.
2014
Extending the hydrophobic cavity of β-cyclodextrin results in more negative heat capacity changes but reduced binding affinities.
Journal of Inclusion Phenomena and Macrocyclic Chemistry.
78.
2014
Fed and fasted state gastro-intestinal in vitro lipolysis: In vitro in vivo relations of a conventional tablet, a SNEDDS and a solidified SNEDDS.
European Journal of Pharmaceutical Sciences.
57.
2014
In Vitro Lipolysis Data Does Not Adequately Predict the In Vivo Performance of Lipid-Based Drug Delivery Systems Containing Fenofibrate.
The AAPS Journal.
16.
2014
In vitro models for the prediction of in vivo performance of oral dosage forms.
European Journal of Pharmaceutical Sciences.
57.
2014
Intestinal absorption of the antiepileptic drug substance vigabatrin in Göttingen mini-pigs is unaffected by co-administration of amino acids.
International Journal of Pharmaceutics.
466.
2014
Intestinal absorption of the antiepileptic drug substance vigabatrin is altered by infant formula in vitro and in vivo..
Pharmacology Research & Perspectives.
2.
2014
Investigating the correlation between in vivo absorption and in vitro release of fenofibrate from lipid matrix particles in biorelevant medium.
European Journal of Pharmaceutical Sciences.
51.
2014
PAT1 (SLC36A1) shows nuclear localization and affects growth of smooth muscle cells from rats.
AJP Endocrinology and Metabolism.
306.
2014
The absorptive flux of the anti-epileptic drug substance vigabatrin is carrier-mediated across Caco-2 cell monolayers.
European Journal of Pharmaceutical Sciences.
51.
2014
The anti-epileptic drug substance vigabatrin inhibits taurine transport in intestinal and renal cell culture models.
International Journal of Pharmaceutics.
473.
2014
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Bile salts and their importance for drug absorption.
International Journal of Pharmaceutics.
2013
In vitro, ex vivo and in vivo examination of buccal absorption of metoprolol with varying pH in TR146 cell culture, porcine buccal mucosa and Göttingen minipigs.
European Journal of Pharmaceutical Sciences.
2013
Lipid-based formulations for oral administration of poorly water-soluble drugs.
International Journal of Pharmaceutics.
2013
Preparation of an amorphous sodium furosemide salt improves solubility and dissolution rate and leads to a faster Tmax after oral dosing to rats.
European Journal of Pharmaceutics and Biopharmaceutics.
2013
Sertraline inhibits the transport of PAT1 substrates in vivo and in vitro.
British Journal of Pharmacology.
2013
Supersaturated Self-Nanoemulsifying Drug Delivery Systems (Super-SNEDDS) Enhance the Bioavailability of the Poorly Water-Soluble Drug Simvastatin in Dogs.
The AAPS Journal.
2013
Thermodynamics of the interaction of γ-cyclodextrin and tauro- and glyco-conjugated bile salts.
Journal of Inclusion Phenomena and Macrocyclic Chemistry.
2013