selected publications
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academic article
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A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer.
Nature Genetics.
50.
2018
AA9int: SNP interaction pattern search using non-hierarchical additive model set..
Bioinformatics.
34.
2018
Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.
Nature Genetics.
50.
2018
Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants.
Nature Communications.
9.
2018
Genetic modifiers of radon-induced lung cancer risk: a genome-wide interaction study in former uranium miners.
International Archives of Occupational and Environmental Health.
91.
2018
Germline variation at 8q24 and prostate cancer risk in men of European ancestry.
Nature Communications.
9.
2018
Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk.
Nature Communications.
9.
2018
Large-scale transcriptome-wide association study identifies new prostate cancer risk regions.
Nature Communications.
9.
2018
The BRCA2 c.68‐7T > A variant is not pathogenic: A model for clinical calibration of spliceogenicity.
Human Mutation.
39.
2018
Association analysis identifies 65 new breast cancer risk loci.
Nature.
551.
2017
BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer.
Cancer Research.
77.
2017
Body mass index and breast cancer survival: a Mendelian randomization analysis.
International Journal of Epidemiology.
46.
2017
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.
Nature Communications.
8.
2017
Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults.
PLOS Genetics.
13.
2017
Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer.
Nature Genetics.
49.
2017
Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer.
Nature Genetics.
49.
2017
Investigating the possible causal role of coffee consumption with prostate cancer risk and progression using Mendelian randomization analysis.
International Journal of Cancer.
140.
2017
Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes.
Nature Genetics.
49.
2017
PHIP - a novel candidate breast cancer susceptibility locus on 6q14.1.
Oncotarget.
8.
2017
The OncoArray Consortium: A Network for Understanding the Genetic Architecture of Common Cancers.
Cancer Epidemiology Biomarkers & Prevention.
26.
2017
An intergenic risk locus containing an enhancer deletion in 2q35 modulates breast cancer risk by deregulating IGFBP5 expression..
Human Molecular Genetics.
25.
2016
Assessing the role of insulin‐like growth factors and binding proteins in prostate cancer using Mendelian randomization: Genetic variants as instruments for circulating levels.
International Journal of Cancer.
139.
2016
Association of breast cancer risk with genetic variants showing differential allelic expression: Identification of a novel breast cancer susceptibility locus at 4q21.
Oncotarget.
5.
2016
Association of genetic susceptibility variants for type 2 diabetes with breast cancer risk in women of European ancestry.
Cancer Causes & Control.
27.
2016
Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation.
Nature Communications.
7.
2016
Blood lipids and prostate cancer: a Mendelian randomization analysis.
Cancer Medicine.
5.
2016
Breast Cancer Risk From Modifiable and Nonmodifiable Risk Factors Among White Women in the United States.
JAMA Oncology.
2.
2016
Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170.
Nature Genetics.
48.
2016
Evidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen-Receptor-Positive Breast Cancer through FGF10 and MRPS30 Regulation.
American Journal of Human Genetics.
99.
2016
Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome.
Nature Communications.
7.
2016
Fine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs).
Scientific Reports.
6.
2016
Fine-Mapping of the 1p11.2 Breast Cancer Susceptibility Locus.
PLoS ONE.
11.
2016
Fine‐scale mapping of 8q24 locus identifies multiple independent risk variants for breast cancer.
International Journal of Cancer.
139.
2016
Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast–ovarian cancer susceptibility locus.
Nature Communications.
7.
2016
Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array.
British Journal of Cancer.
114.
2016
Genetic predisposition to ductal carcinoma in situ of the breast.
Breast Cancer Research.
18.
2016
Genetic variation in the immunosuppression pathway genes and breast cancer susceptibility: a pooled analysis of 42,510 cases and 40,577 controls from the Breast Cancer Association Consortium.
Human Genetics.
135.
2016
Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent.
PLoS Medicine.
13.
2016
Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types.
Cancer Discovery.
6.
2016
Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer.
Nature Communications.
7.
2016
Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus.
Breast Cancer Research.
18.
2016
No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer.
Gynecologic Oncology.
141.
2016
No evidence that protein truncating variants in BRIP1 are associated with breast cancer risk: implications for gene panel testing.
Journal of Medical Genetics.
53.
2016
PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS.
Journal of Medical Genetics.
53.
2016
Polyunsaturated fatty acids and prostate cancer risk: a Mendelian randomisation analysis from the PRACTICAL consortium.
British Journal of Cancer.
115.
2016
Pubertal development and prostate cancer risk: Mendelian randomization study in a population-based cohort.
BMC Medicine.
14.
2016
RAD51B in Familial Breast Cancer.
PLoS ONE.
11.
2016
SNP interaction pattern identifier (SIPI): an intensive search for SNP–SNP interaction patterns.
Bioinformatics.
33.
2016
rs2735383, located at a microRNA binding site in the 3’UTR of NBS1, is not associated with breast cancer risk.
Scientific Reports.
6.
2016
A Genome-wide Pleiotropy Scan for Prostate Cancer Risk.
European Urology.
67.
2015
A Large-Scale Analysis of Genetic Variants within Putative miRNA Binding Sites in Prostate Cancer.
Cancer Discovery.
5.
2015
Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types.
Journal of the National Cancer Institute.
107.
2015
Association of breast cancer risk loci with breast cancer survival.
International Journal of Cancer.
137.
2015
CAUSEL: an epigenome- and genome-editing pipeline for establishing function of noncoding GWAS variants.
Nature Medicine.
21.
2015
Characterization of Large Structural Genetic Mosaicism in Human Autosomes.
American Journal of Human Genetics.
96.
2015
Common germline polymorphisms associated with breast cancer-specific survival.
Breast Cancer Research.
17.
2015
Fine-Scale Mapping of the 4q24 Locus Identifies Two Independent Loci Associated with Breast Cancer Risk.
Cancer Epidemiology Biomarkers & Prevention.
24.
2015
Fine-Scale Mapping of the 5q11.2 Breast Cancer Locus Reveals at Least Three Independent Risk Variants Regulating MAP3K1.
American Journal of Human Genetics.
96.
2015
Fine-mapping identifies two additional breast cancer susceptibility loci at 9q31.2.
Human Molecular Genetics.
24.
2015
Genetic studies of body mass index yield new insights for obesity biology.
Nature.
518.
2015
Genome-Wide Association Study of Prostate Cancer–Specific Survival.
Cancer Epidemiology Biomarkers & Prevention.
24.
2015
Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer.
Nature Genetics.
47.
2015
Height and Breast Cancer Risk: Evidence From Prospective Studies and Mendelian Randomization.
Journal of the National Cancer Institute.
107.
2015
Identification and characterization of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk.
Human Molecular Genetics.
24.
2015
Identification of Novel Genetic Markers of Breast Cancer Survival.
Journal of the National Cancer Institute.
107.
2015
Inherited variants in the inner centromere protein (INCENP) gene of the chromosomal passenger complex contribute to the susceptibility of ER-negative breast cancer.
Carcinogenesis.
36.
2015
Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair.
Nature Genetics.
47.
2015
Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores.
American Journal of Human Genetics.
97.
2015
Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans.
Human Molecular Genetics.
24.
2015
New genetic loci link adipose and insulin biology to body fat distribution.
Nature.
518.
2015
Polymorphisms in a Putative Enhancer at the 10q21.2 Breast Cancer Risk Locus Regulate NRBF2 Expression.
American Journal of Human Genetics.
97.
2015
Prediction of Breast Cancer Risk Based on Profiling With Common Genetic Variants.
Journal of the National Cancer Institute.
107.
2015
Prediction of individual genetic risk to prostate cancer using a polygenic score.
The Prostate.
75.
2015
Risk Analysis of Prostate Cancer in PRACTICAL, a Multinational Consortium, Using 25 Known Prostate Cancer Susceptibility Loci.
Cancer Epidemiology Biomarkers & Prevention.
24.
2015
SNP-SNP interaction analysis of NF-κB signaling pathway on breast cancer survival.
Oncotarget.
6.
2015
The effects of height and BMI on prostate cancer incidence and mortality: a Mendelian randomization study in 20,848 cases and 20,214 controls from the PRACTICAL consortium.
Cancer Causes & Control.
26.
2015
Vitamin D–Associated Genetic Variation and Risk of Breast Cancer in the Breast and Prostate Cancer Cohort Consortium (BPC3).
Cancer Epidemiology Biomarkers & Prevention.
24.
2015
A large-scale assessment of two-way SNP interactions in breast cancer susceptibility using 46 450 cases and 42 461 controls from the breast cancer association consortium.
Human Molecular Genetics.
23.
2014
A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer.
Nature Genetics.
46.
2014
Additive Interactions Between Susceptibility Single-Nucleotide Polymorphisms Identified in Genome-Wide Association Studies and Breast Cancer Risk Factors in the Breast and Prostate Cancer Cohort Consortium.
American Journal of Epidemiology.
180.
2014
Common non-synonymous SNPs associated with breast cancer susceptibility: findings from the Breast Cancer Association Consortium.
Human Molecular Genetics.
23.
2014
Defining the role of common variation in the genomic and biological architecture of adult human height.
Nature Genetics.
46.
2014
Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation.
Nature Communications.
5.
2014
FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium.
British Journal of Cancer.
110.
2014
Fine-Mapping the HOXB Region Detects Common Variants Tagging a Rare Coding Allele: Evidence for Synthetic Association in Prostate Cancer.
PLOS Genetics.
10.
2014
Genetic Predisposition to In Situ and Invasive Lobular Carcinoma of the Breast.
PLOS Genetics.
10.
2014
Genetic variation in mitotic regulatory pathway genes is associated with breast tumor grade.
Human Molecular Genetics.
23.
2014
Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33.
Human Molecular Genetics.
23.
2014
Refined histopathological predictors of BRCA1 and BRCA2mutation status: a large-scale analysis of breast cancer characteristics from the BCAC, CIMBA, and ENIGMA consortia.
Breast Cancer Research.
16.
2014
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dataset
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MOESM1 of Prediction and clinical utility of a contralateral breast cancer risk model.
springer-nature.
2019
MOESM2 of Prediction and clinical utility of a contralateral breast cancer risk model.
springer-nature.
2019
Genes of biological interest within 500 kb of lead SNPs associated with BMI..
public-library-of-science.
2017
Genes of biological interest within 500 kb of lead SNPs associated with WCadjBMI or WHRadjBMI..
public-library-of-science.
2017
Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults.
public-library-of-science.
2017
Novel loci achieving genome-wide significance (P<5x10-8) in meta-analyses for PA-adjusted SNP main effect (PadjPA) or the joint test of SNP main effect and SNP-PA interaction (Pjoint)..
public-library-of-science.
2017
Additional file 2: of Pubertal development and prostate cancer risk: Mendelian randomization study in a population-based cohort.
springer-nature.
2016
Associations between genetically predicted BMI and breast cancer risk..
public-library-of-science.
2016
Associations of the weighted BMI-GSs with BMI and traditional breast cancer risk factors..
public-library-of-science.
2016
Estimated haplotype frequencies and haplotype-specific ORs among the BCAC dataset..
public-library-of-science.
2016
Fine-Mapping of the 1p11.2 Breast Cancer Susceptibility Locus.
public-library-of-science.
2016
Frequencies and ORs for the SNPs rs2588809, rs1314913, and rs999737 for all breast cancer cases, familial cases and ER-positive and -negative cases in the BCAC dataset..
public-library-of-science.
2016
Frequencies and ORs for the c.541C>T mutation among the different patient subgroups in the Helsinki, Tampere, Oulu, and Belarus series..
public-library-of-science.
2016
Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent.
public-library-of-science.
2016
RAD51B in Familial Breast Cancer.
public-library-of-science.
2016
Significant associations detected at p < 0.05 between breast cancer risk and BMI-related SNPs..
public-library-of-science.
2016
Two independent association signals at the 1p11.2 locus: Association results for breast cancer risk among European women in BCAC, by tumor characteristic..
public-library-of-science.
2016
Two independent association signals at the 1p11.2 locus: Association results for breast cancer risk among women in BCAC, by ancestry..
public-library-of-science.
2016
Variants identified in the screening of the RAD51B gene (RefSeq NM_133509.3)..
public-library-of-science.
2016
Identification of a BRCA2-Specific Modifier Locus at 6p24 Related to Breast Cancer Risk.
public-library-of-science.
2015
Fine-Mapping the HOXB Region Detects Common Variants Tagging a Rare Coding Allele: Evidence for Synthetic Association in Prostate Cancer.
public-library-of-science.
2014
Haplotype analysis for rs117576373 and rs138213197 in the subset of 5500 PrCa cases and 4923 controls from the UK and Sweden for which both had been directly genotyped..
public-library-of-science.
2014
Haplotype analysis for rs145922598 and rs138213197 in the subset of 5500 PrCa cases and 4923 controls from the UK and Sweden genotyped for rs138213197..
public-library-of-science.
2014
PrCa association information for SNPs significant at P<10−6 in the iCOGS imputed data..
public-library-of-science.
2014
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hide from search
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Breast cancer hazard ratios (HR) and 95% confidence intervals (CI) of novel breast cancer loci with P-values of association <10−5 among BRCA2 mutation carriers..
public-library-of-science.
2013
Genetic Variation in the HSD17B1 Gene and Risk of Prostate Cancer.
public-library-of-science.
2013
Per allele hazard ratios (HR) and 95% confidence intervals (CI) of previously published breast cancer loci among BRCA2 mutation carriers from previous reports and from the iCOGS array, ordered by statistical significance of the region..
public-library-of-science.
2013
A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease.
Human Molecular Genetics.
2013
Fine-Scale Mapping of the FGFR2 Breast Cancer Risk Locus: Putative Functional Variants Differentially Bind FOXA1 and E2F1.
American Journal of Human Genetics.
2013
Identification of a BRCA2-Specific Modifier Locus at 6p24 Related to Breast Cancer Risk.
PLOS Genetics.
2013
Insulin‐like growth factor pathway genes and blood concentrations, dietary protein and risk of prostate cancer in the NCI Breast and Prostate Cancer Cohort Consortium (BPC3).
International Journal of Cancer.
2013
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer.
Nature Genetics.
2013
Heterogeneity of Breast Cancer Associations with Five Susceptibility Loci by Clinical and Pathological Characteristics.
public-library-of-science.
2008
Multivariate Cox proportional hazards analysis of genetic polymorphisms in relation to overall survival following breast cancer diagnosis, by ER status*..
public-library-of-science.
2008
Odds ratios for breast cancer risk by lymph node involvement*..
public-library-of-science.
2008
Odds ratios for breast cancer risk by tumor grade*..
public-library-of-science.
2008
Per-allele odds ratios for breast cancer risk by estrogen receptor status..
public-library-of-science.
2008