selected publications
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academic article
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A Genetic Investigation of Sex Bias in the Prevalence of Attention-Deficit/Hyperactivity Disorder.
Biological Psychiatry.
83.
2018
ASD and schizophrenia show distinct developmental profiles in common genetic overlap with population-based social communication difficulties.
Molecular Psychiatry.
23.
2018
Analysis of shared heritability in common disorders of the brain.
Science.
360.
2018
Brain volumetric alterations accompanied with loss of striatal medium-sized spiny neurons and cortical parvalbumin expressing interneurons in Brd1+/− mice.
Scientific Reports.
8.
2018
Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection.
Nature Genetics.
50.
2018
Complex spatio-temporal distribution and genomic ancestry of mitochondrial DNA haplogroups in 24,216 Danes.
PLoS ONE.
13.
2018
Elevated polygenic burden for autism is associated with differential DNA methylation at birth.
Genome Medicine.
10.
2018
Evaluating the Feasibility of DNA Methylation Analyses Using Long-Term Archived Brain Formalin-Fixed Paraffin-Embedded Samples.
Molecular Neurobiology.
55.
2018
Genetics of suicide attempts in individuals with and without mental disorders: a population-based genome-wide association study.
Molecular Psychiatry.
2018
Genome-wide analyses of self-reported empathy: correlations with autism, schizophrenia, and anorexia nervosa.
Translational Psychiatry.
8.
2018
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression.
Nature Genetics.
50.
2018
Prevalence of rearrangements in the 22q11.2 region and population-based risk of neuropsychiatric and developmental disorders in a Danish population: a case-cohort study.
The Lancet Psychiatry.
5.
2018
Psychiatric Genomics: An Update and an Agenda.
American Journal of Psychiatry.
175.
2018
Quantifying the Impact of Rare and Ultra-rare Coding Variation across the Phenotypic Spectrum.
American Journal of Human Genetics.
102.
2018
Schizophrenia-associated mt-DNA SNPs exhibit highly variable haplogroup affiliation and nuclear ancestry: Bi-genomic dependence raises major concerns for link to disease.
PLoS ONE.
13.
2018
The association between neonatal vitamin D status and risk of schizophrenia.
Scientific Reports.
8.
2018
The iPSYCH2012 case–cohort sample: new directions for unravelling genetic and environmental architectures of severe mental disorders.
Molecular Psychiatry.
23.
2018
The importance of data structure in statistical analysis of dendritic spine morphology.
Journal of Neuroscience Methods.
296.
2018
The role of genetic liability in the association of urbanicity at birth and during upbringing with schizophrenia in Denmark.
Psychological Medicine.
48.
2018
100 Investigating the Overlap between Common Genetic Factors for ADHD Risk and Brain Volume Measures.
Biological Psychiatry.
81.
2017
5 Mitochondrial DNA Haplogroups are Associated with Psychiatric Disease: A Nation-Wide Study of 74,763 Danes.
Biological Psychiatry.
81.
2017
An Analysis of Two Genome-wide Association Meta-analyses Identifies a New Locus for Broad Depression Phenotype.
Biological Psychiatry.
82.
2017
Assembly and analysis of 100 full MHC haplotypes from the Danish population.
Genome Research.
27.
2017
Association of The Polygenic Risk Score For Schizophrenia With Mortality And Suicidal Behaviour - A Danish Population-Based Study.
European Neuropsychopharmacology.
27.
2017
Association of the polygenic risk score for schizophrenia with mortality and suicidal behavior - A Danish population-based study.
Schizophrenia Research.
184.
2017
Blood DNA methylation age is not associated with cognitive functioning in middle-aged monozygotic twins.
Neurobiology of Aging.
50.
2017
COMT Val158Met and MTHFR C677T moderate risk of schizophrenia in response to childhood adversity.
Acta Psychiatrica Scandinavica.
136.
2017
Changes in cognitive functions and cerebral grey matter and their associations with inflammatory markers, endocrine markers, and APOE genotypes in testicular cancer patients undergoing treatment.
Brain Imaging and Behavior.
11.
2017
DNA Methylation Analysis of BRD1 Promoter Regions and the Schizophrenia rs138880 Risk Allele.
PLoS ONE.
12.
2017
Endogenous and Antipsychotic-Related Risks for Diabetes Mellitus in Young People With Schizophrenia: A Danish Population-Based Cohort Study.
American Journal of Psychiatry.
174.
2017
Epigenome-Wide Association Study of Cognitive Functioning in Middle-Aged Monozygotic Twins.
Frontiers in Aging Neuroscience.
9.
2017
Genome-Wide Significant LOCI Identified In Attention Deficit Hyperactivity Disorder And Autism Spectrum Disorder.
European Neuropsychopharmacology.
27.
2017
Genome-wide Association for Major Depression Through Age at Onset Stratification: Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium.
Biological Psychiatry.
81.
2017
Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia.
Translational Psychiatry.
7.
2017
Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity.
Nature Communications.
8.
2017
Lung function discordance in monozygotic twins and associated differences in blood DNA methylation.
Clinical Epigenetics.
9.
2017
Mice heterozygous for an inactivated allele of the schizophrenia associated Brd1 gene display selective cognitive deficits with translational relevance to schizophrenia.
Neurobiology of Learning and Memory.
141.
2017
Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders.
Nature Genetics.
49.
2017
Sequencing and de novo assembly of 150 genomes from Denmark as a population reference.
Nature.
548.
2017
The Genome-Wide DNA Methylation Profile of Peripheral Blood Is Not Systematically Changed by Short-Time Storage at Room Temperature.
Epigenomes.
1.
2017
The Schizophrenia-Associated BRD1 Gene Regulates Behavior, Neurotransmission, and Expression of Schizophrenia Risk Enriched Gene Sets in Mice.
Biological Psychiatry.
82.
2017
Whole-exome sequencing of individuals from an isolated population implicates rare risk variants in bipolar disorder.
Translational Psychiatry.
7.
2017
Analyzing the Role of MicroRNAs in Schizophrenia in the Context of Common Genetic Risk Variants.
JAMA Psychiatry.
73.
2016
Antidepressant medication during pregnancy and epigenetic changes in umbilical cord blood: a systematic review.
Clinical Epigenetics.
8.
2016
Association between genes on chromosome 19p13.2 and panic disorder.
Psychiatric Genetics.
26.
2016
CACNA1C hypermethylation is associated with bipolar disorder.
Translational Psychiatry.
6.
2016
Covariance Association Test (CVAT) Identifies Genetic Markers Associated with Schizophrenia in Functionally Associated Biological Processes.
Genetics.
203.
2016
DNA Methylation at the Neonatal State and at the Time of Diagnosis: Preliminary Support for an Association with the Estrogen Receptor 1, Gamma-Aminobutyric Acid B Receptor 1, and Myelin Oligodendrocyte Glycoprotein in Female Adolescent Patients with OCD.
Frontiers in Psychiatry.
7.
2016
Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population.
Nature Genetics.
48.
2016
Genome-wide DNA methylation profiling with MeDIP-seq using archived dried blood spots.
Clinical Epigenetics.
8.
2016
High loading of polygenic risk in cases with chronic schizophrenia.
Molecular Psychiatry.
21.
2016
High-Quality Exome Sequencing of Whole-Genome Amplified Neonatal Dried Blood Spot DNA.
PLoS ONE.
11.
2016
Hypomethylation of FAM63B in bipolar disorder patients.
Clinical Epigenetics.
8.
2016
Identification of the BRD1 interaction network and its impact on mental disorder risk.
Genome Medicine.
8.
2016
Influence of Polygenic Risk Scores on the Association Between Infections and Schizophrenia.
Biological Psychiatry.
80.
2016
No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study.
PLOS Genetics.
12.
2016
Quantitative assessment of methyl‐esterification and other side reactions in a standard propionylation protocol for detection of histone modifications.
Proteomics.
16.
2016
Schizophrenia risk variants affecting microRNA function and site-specific regulation of NT5C2 by miR-206.
European Neuropsychopharmacology.
26.
2016
Whole-Exome Sequencing Reveals Increased Burden of Rare Functional and Disruptive Variants in Candidate Risk Genes in Individuals With Persistent Attention-Deficit/Hyperactivity Disorder.
Journal of the American Academy of Child & Adolescent Psychiatry.
55.
2016
Whole‐exome sequencing implicates DGKH as a risk gene for panic disorder in the Faroese population.
American Journal of Medical Genetics Part B Neuropsychiatric Genetics.
171.
2016
A Novel Locus Harbouring a Functional CD164 Nonsense Mutation Identified in a Large Danish Family with Nonsyndromic Hearing Impairment.
PLOS Genetics.
11.
2015
Aberrant recombination and repair during immunoglobulin class switching in BRCA1-deficient human B cells.
Proceedings of the National Academy of Sciences of the United States of America.
112.
2015
Analysis of t(9;17)(q33.2;q25.3) chromosomal breakpoint regions and genetic association reveals novel candidate genes for bipolar disorder.
Bipolar Disorders.
17.
2015
EWS and FUS bind a subset of transcribed genes encoding proteins enriched in RNA regulatory functions.
BMC Genomics.
16.
2015
Experimental validation of methods for differential gene expression analysis and sample pooling in RNA-seq.
BMC Genomics.
16.
2015
Increased serum levels of sortilin are associated with depression and correlated with BDNF and VEGF.
Translational Psychiatry.
5.
2015
Investigating interactions between early life stress and two single nucleotide polymorphisms in HSD11B2 on the risk of schizophrenia.
Psychoneuroendocrinology.
60.
2015
Novel variation and de novo mutation rates in population-wide de novo assembled Danish trios.
Nature Communications.
6.
2015
Polygenic Risk Score, Parental Socioeconomic Status, Family History of Psychiatric Disorders, and the Risk for Schizophrenia: A Danish Population-Based Study and Meta-analysis.
JAMA Psychiatry.
72.
2015
Systematic Integration of Brain eQTL and GWAS Identifies ZNF323 as a Novel Schizophrenia Risk Gene and Suggests Recent Positive Selection Based on Compensatory Advantage on Pulmonary Function.
Schizophrenia Bulletin.
41.
2015
Are TMEM genes potential candidate genes for panic disorder?.
Psychiatric Genetics.
24.
2014
Common variant at 16p11.2 conferring risk of psychosis.
Molecular Psychiatry.
19.
2014
Cuba: Exploring the History of Admixture and the Genetic Basis of Pigmentation Using Autosomal and Uniparental Markers.
PLOS Genetics.
10.
2014
Depression and BMI influences the serum vascular endothelial growth factor level.
The International Journal of Neuropsychopharmacology.
17.
2014
GWAS, Cytomegalovirus Infection, and Schizophrenia.
Current Behavioral Neuroscience Reports.
1.
2014
Genome-wide study of association and interaction with maternal cytomegalovirus infection suggests new schizophrenia loci.
Molecular Psychiatry.
19.
2014
Integrated Pathway-Based Approach Identifies Association between Genomic Regions at CTCF and CACNB2 and Schizophrenia.
PLOS Genetics.
10.
2014
No association of polymorphisms in the serotonin transporter gene with thermal pain sensation in healthy individuals.
Molecular Pain.
10.
2014
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dataset
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Supplementary Tables 1-8 from Variable DNA methylation in neonates mediates the association between prenatal smoking and birth weight.
the-royal-society.
2019
Supplementary Tables 1-8 from Variable DNA methylation in neonates mediates the association between prenatal smoking and birth weight.
the-royal-society.
2019
Additional file 3: of Elevated polygenic burden for autism is associated with differential DNA methylation at birth.
springer-nature.
2018
Additional file 4: of Elevated polygenic burden for autism is associated with differential DNA methylation at birth.
springer-nature.
2018
Association of SNPs with SZ in Danish nuclear ancestry and a specific mtDNA haplogroup..
public-library-of-science.
2018
Complex spatio-temporal distribution and genomic ancestry of mitochondrial DNA haplogroups in 24,216 Danes.
public-library-of-science.
2018
Distribution of mtDNA haplogroups constituting the macro-hg R..
public-library-of-science.
2018
Distribution of mtDNA haplogroups contained within the N and M macro hgs..
public-library-of-science.
2018
Distribution of mtDNA macro hgs L0-L6, M, N and R..
public-library-of-science.
2018
Distribution of mtDNA sub-haplogroups of H, V, J, T, K, and U, the most frequent European haplogroups..
public-library-of-science.
2018
Distribution of the most frequent haplogroups in the five administrative regions of Denmark..
public-library-of-science.
2018
Distributions of the most frequent haplogroups in the period 1981–1986 and 2000–2005..
public-library-of-science.
2018
Schizophrenia associated mtDNA SNPs, their frequency, mtDNA hg association, and link with disease..
public-library-of-science.
2018
Schizophrenia-associated mt-DNA SNPs exhibit highly variable haplogroup affiliation and nuclear ancestry: Bi-genomic dependence raises major concerns for link to disease.
public-library-of-science.
2018
DNA Methylation Analysis of BRD1 Promoter Regions and the Schizophrenia rs138880 Risk Allele.
public-library-of-science.
2017
Additional file 12: of Identification of the BRD1 interaction network and its impact on mental disorder risk.
springer-nature.
2016
Additional file 14: of Identification of the BRD1 interaction network and its impact on mental disorder risk.
springer-nature.
2016
Additional file 16: of Identification of the BRD1 interaction network and its impact on mental disorder risk.
springer-nature.
2016
Additional file 9: of Identification of the BRD1 interaction network and its impact on mental disorder risk.
springer-nature.
2016
Descriptive data for the unimputed (post-QC) PGC replication data—ROHs defined as ≥ 110 consecutive homozygous SNPs or as ≥ 2.3 Mb long..
public-library-of-science.
2016
High-Quality Exome Sequencing of Whole-Genome Amplified Neonatal Dried Blood Spot DNA.
public-library-of-science.
2016
No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study.
public-library-of-science.
2016
A Novel Locus Harbouring a Functional CD164 Nonsense Mutation Identified in a Large Danish Family with Nonsyndromic Hearing Impairment.
public-library-of-science.
2015
Additional file 1: of EWS and FUS bind a subset of transcribed genes encoding proteins enriched in RNA regulatory functions.
springer-nature.
2015
Additional file 2: of EWS and FUS bind a subset of transcribed genes encoding proteins enriched in RNA regulatory functions.
springer-nature.
2015
Additional file 7: of EWS and FUS bind a subset of transcribed genes encoding proteins enriched in RNA regulatory functions.
springer-nature.
2015
Additional file 8: of EWS and FUS bind a subset of transcribed genes encoding proteins enriched in RNA regulatory functions.
springer-nature.
2015
Additional file 9: of EWS and FUS bind a subset of transcribed genes encoding proteins enriched in RNA regulatory functions.
springer-nature.
2015
Association of genetic markers within or nearby skin pigmentation genes with melanin levels..
public-library-of-science.
2014
Comparisons of FDRs (BH) and p-values (P) for the BOMA-UTR and the GAIN-MGS data sets for the replicated pathways..
public-library-of-science.
2014
Cuba: Exploring the History of Admixture and the Genetic Basis of Pigmentation Using Autosomal and Uniparental Markers.
public-library-of-science.
2014
Demographic characteristics of the sample..
public-library-of-science.
2014
Description of individual samples..
public-library-of-science.
2014
Integrated Pathway-Based Approach Identifies Association between Genomic Regions at CTCF and CACNB2 and Schizophrenia.
public-library-of-science.
2014
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hide from search
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Genetic polymorphisms genotyped in this study..
public-library-of-science.
2013
Minor allele association with personality trait scores..
public-library-of-science.
2013
Table S1 - Polymorphism in Serotonin Receptor 3B Is Associated with Pain Catastrophizing.
public-library-of-science.
2013
An association study between the norepinephrine transporter gene and depression.
Psychiatric Genetics.
2013
An association study of suicide and candidate genes in the serotonergic system.
Journal of Affective Disorders.
2013
Emotional modulation of muscle pain is associated with polymorphisms in the serotonin transporter gene.
Pain.
2013
Genome wide assessment of mRNA in astrocyte protrusions by direct RNA sequencing reveals mRNA localization for the intermediate filament protein nestin.
Glia.
2013
Polymorphism in Serotonin Receptor 3B Is Associated with Pain Catastrophizing.
PLoS ONE.
2013
Polymorphisms of Muscle Genes Are Associated with Bone Mass and Incident Osteoporotic Fractures in Caucasians.
Calcified Tissue International.
2013
Association of multiple sclerosis with rs391745 located near HERV-Fc1..
public-library-of-science.
2011
Association of multiple sclerosis with the polymorphism rs3802981 located in the first intron of TRIM5..
public-library-of-science.
2011
Comparison of clinical and morphometric findings in Seckel (SCKL2) and Jawad patients..
public-library-of-science.
2011
CtIP Mutations Cause Seckel and Jawad Syndromes.
public-library-of-science.
2011
The Etiology of Multiple Sclerosis: Genetic Evidence for the Involvement of the Human Endogenous Retrovirus HERV-Fc1.
public-library-of-science.
2011
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patent
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preprint
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A Major Role for Common Genetic Variation in Anxiety Disorders.
bioRxiv.
2017
A genetic investigation of sex bias in the prevalence of attention deficit hyperactivity disorder.
bioRxiv.
2017
A genome-wide association study for shared risk across major psychiatric disorders in a nation-wide birth cohort implicates fetal neurodevelopment as a key mediator.
bioRxiv.
2017
Common risk variants identified in autism spectrum disorder.
bioRxiv.
2017
Complex spatio-temporal distribution and genogeographic affinity of mitochondrial DNA haplogroups in 24,216 Danes.
bioRxiv.
2017
Discovery of the first genome-wide significant risk loci for ADHD.
bioRxiv.
2017
Elevated polygenic burden for autism is associated with differential DNA methylation at birth.
bioRxiv.
2017
Gene expression imputation across multiple brain regions reveals schizophrenia risk throughout development.
bioRxiv.
2017
Genetic markers of ADHD-related variations in intracranial volume.
bioRxiv.
2017
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depressive disorder.
bioRxiv.
2017
Genome-wide association study identifies 30 Loci Associated with Bipolar Disorder.
bioRxiv.
2017
Genome-wide association study implicates CHRNA2 in cannabis use disorder.
bioRxiv.
2017
Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes.
bioRxiv.
2017
Mitochondrial DNA SNPs associated with Schizophrenia exhibit Highly Variable Inter-allelic Haplogroup Affiliation and Nuclear Genogeographic Affinity: Bi-Genomic Linkage Disequilibrium raises Major Concerns for Link to Disease.
bioRxiv.
2017
Psychiatric Genomics: An Update and an Agenda.
bioRxiv.
2017
Quantifying the impact of rare and ultra-rare coding variation across the phenotypic spectrum.
bioRxiv.
2017
Social and non-social autism symptom and trait domains are genetically dissociable.
bioRxiv.
2017
The iPSYCH2012 case-cohort sample: New directions for unravelling genetic and environmental architectures of severe mental disorders.
bioRxiv.
2017
A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects: CNV Analysis Group and the Schizophrenia Working Group of the Psychiatric Genomics Consortium.
bioRxiv.
2016
Genome-wide analyses of self-reported empathy: correlations with autism, schizophrenia, and anorexia nervosa.
bioRxiv.
2016
Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders.
bioRxiv.
2016
Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population.
bioRxiv.
2015