Accurate H3K27 methylation can be established de novo by SUZ12-directed PRC2.
Nature Structural & Molecular Biology.
EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas.
Regional tumour glutamine supply affects chromatin and cell identity.
Nature Cell Biology.
Role of the Polycomb Repressive Complex 2 (PRC2) in Transcriptional Regulation and Cancer.
Cold Spring Harbor Perspectives in Medicine.
The lncRNA MIR31HG regulates p16INK4A expression to modulate senescence.
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Histone lysine demethylases as targets for anticancer therapy.
Nature Reviews Drug Discovery.
Reduced H3K27me3 and DNA Hypomethylation Are Major Drivers of Gene Expression in K27M Mutant Pediatric High-Grade Gliomas.