selected publications
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academic article
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A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer.
Nature Genetics.
50.
2018
Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study.
British Journal of Cancer.
118.
2018
Assessment of moderate coffee consumption and risk of epithelial ovarian cancer: a Mendelian randomization study.
International Journal of Epidemiology.
47.
2018
GLI2 promoter hypermethylation in saliva of children with a respiratory allergy.
Clinical Epigenetics.
10.
2018
Joint associations of a polygenic risk score and environmental risk factors for breast cancer in the Breast Cancer Association Consortium..
International Journal of Epidemiology.
47.
2018
The BRCA2 c.68‐7T > A variant is not pathogenic: A model for clinical calibration of spliceogenicity.
Human Mutation.
39.
2018
The genetic landscape of 87 ovarian germ cell tumors.
Gynecologic Oncology.
151.
2018
Variants in genes encoding small GTPases and association with epithelial ovarian cancer susceptibility.
PLoS ONE.
13.
2018
rs495139 in the TYMS-ENOSF1 Region and Risk of Ovarian Carcinoma of Mucinous Histology.
International Journal of Molecular Sciences.
19.
2018
Analyses of germline variants associated with ovarian cancer survival identify functional candidates at the 1q22 and 19p12 outcome loci.
Oncotarget.
5.
2017
Analyses of germline variants associated with ovarian cancer survival identify functional candidates at the 1q22 and 19p12 outcome loci..
Oncotarget.
8.
2017
Association analysis identifies 65 new breast cancer risk loci.
Nature.
551.
2017
BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer.
Cancer Research.
77.
2017
Body mass index and breast cancer survival: a Mendelian randomization analysis.
International Journal of Epidemiology.
46.
2017
Enrichment of putative PAX8 target genes at serous epithelial ovarian cancer susceptibility loci.
British Journal of Cancer.
116.
2017
Genetic modifiers of CHEK2*1100delC-associated breast cancer risk.
Genetics in Medicine.
19.
2017
Gene–environment interactions involving functional variants: Results from the Breast Cancer Association Consortium.
International Journal of Cancer.
141.
2017
Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk.
Nature Genetics.
49.
2017
Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer.
Nature Genetics.
49.
2017
Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer.
Nature Genetics.
49.
2017
No Evidence That Genetic Variation in the Myeloid-Derived Suppressor Cell Pathway Influences Ovarian Cancer Survival.
Cancer Epidemiology Biomarkers & Prevention.
26.
2017
PHIP - a novel candidate breast cancer susceptibility locus on 6q14.1.
Oncotarget.
8.
2017
Predictors of pretreatment CA125 at ovarian cancer diagnosis: a pooled analysis in the Ovarian Cancer Association Consortium.
Cancer Causes & Control.
28.
2017
Reproductive profiles and risk of breast cancer subtypes: a multi-center case-only study.
Breast Cancer Research.
19.
2017
Adult body mass index and risk of ovarian cancer by subtype: a Mendelian randomization study.
International Journal of Epidemiology.
45.
2016
An intergenic risk locus containing an enhancer deletion in 2q35 modulates breast cancer risk by deregulating IGFBP5 expression..
Human Molecular Genetics.
25.
2016
Assessing the genetic architecture of epithelial ovarian cancer histological subtypes.
Human Genetics.
135.
2016
Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with risk of clear cell ovarian cancer.
Oncotarget.
7.
2016
Association of breast cancer risk with genetic variants showing differential allelic expression: Identification of a novel breast cancer susceptibility locus at 4q21.
Oncotarget.
5.
2016
Association of vitamin D levels and risk of ovarian cancer: a Mendelian randomization study.
International Journal of Epidemiology.
45.
2016
BRCA2 Polymorphic Stop Codon K3326X and the Risk of Breast, Prostate, and Ovarian Cancers.
Journal of the National Cancer Institute.
108.
2016
Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170.
Nature Genetics.
48.
2016
Evidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen-Receptor-Positive Breast Cancer through FGF10 and MRPS30 Regulation.
American Journal of Human Genetics.
99.
2016
Fine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs).
Scientific Reports.
6.
2016
Fine‐scale mapping of 8q24 locus identifies multiple independent risk variants for breast cancer.
International Journal of Cancer.
139.
2016
Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast–ovarian cancer susceptibility locus.
Nature Communications.
7.
2016
Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes.
Nature Genetics.
48.
2016
Genetic predisposition to ductal carcinoma in situ of the breast.
Breast Cancer Research.
18.
2016
Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types.
Cancer Discovery.
6.
2016
Germline polymorphisms in an enhancer of PSIP1 are associated with progression-free survival in epithelial ovarian cancer.
Oncotarget.
7.
2016
Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer.
Nature Communications.
7.
2016
Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus.
Breast Cancer Research.
18.
2016
Inherited variants affecting RNA editing may contribute to ovarian cancer susceptibility: results from a large-scale collaboration.
Oncotarget.
5.
2016
No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer.
Gynecologic Oncology.
141.
2016
No evidence that protein truncating variants in BRIP1 are associated with breast cancer risk: implications for gene panel testing.
Journal of Medical Genetics.
53.
2016
PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS.
Journal of Medical Genetics.
53.
2016
CYP19A1 fine-mapping and Mendelian randomization: estradiol is causal for endometrial cancer.
Endocrine Related Cancer.
23.
2015
Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer.
Nature Communications.
6.
2015
Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk.
PLoS ONE.
10.
2015
Common Genetic Variation in Circadian Rhythm Genes and Risk of Epithelial Ovarian Cancer (EOC).
Journal of Genetics and Genome Research.
2.
2015
Common variants at the CHEK2 gene locus and risk of epithelial ovarian cancer.
Carcinogenesis.
36.
2015
Epithelial‐Mesenchymal Transition (EMT) Gene Variants and Epithelial Ovarian Cancer (EOC) Risk.
Genetic Epidemiology.
39.
2015
Evaluating the ovarian cancer gonadotropin hypothesis: A candidate gene study.
Gynecologic Oncology.
136.
2015
Fine-Scale Mapping of the 4q24 Locus Identifies Two Independent Loci Associated with Breast Cancer Risk.
Cancer Epidemiology Biomarkers & Prevention.
24.
2015
Fine-Scale Mapping of the 5q11.2 Breast Cancer Locus Reveals at Least Three Independent Risk Variants Regulating MAP3K1.
American Journal of Human Genetics.
96.
2015
Fine-mapping identifies two additional breast cancer susceptibility loci at 9q31.2.
Human Molecular Genetics.
24.
2015
Genome-wide Analysis Identifies Novel Loci Associated with Ovarian Cancer Outcomes: Findings from the Ovarian Cancer Association Consortium.
Clinical Cancer Research.
21.
2015
Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer.
Nature Genetics.
47.
2015
Germline Mutation in BRCA1 or BRCA2 and Ten-Year Survival for Women Diagnosed with Epithelial Ovarian Cancer.
Clinical Cancer Research.
21.
2015
Height and Breast Cancer Risk: Evidence From Prospective Studies and Mendelian Randomization.
Journal of the National Cancer Institute.
107.
2015
Identification and characterization of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk.
Human Molecular Genetics.
24.
2015
Identification of Novel Genetic Markers of Breast Cancer Survival.
Journal of the National Cancer Institute.
107.
2015
Identification of six new susceptibility loci for invasive epithelial ovarian cancer.
Nature Genetics.
47.
2015
Inherited variants in the inner centromere protein (INCENP) gene of the chromosomal passenger complex contribute to the susceptibility of ER-negative breast cancer.
Carcinogenesis.
36.
2015
Investigation of gene‐environment interactions between 47 newly identified breast cancer susceptibility loci and environmental risk factors.
International Journal of Cancer.
136.
2015
Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair.
Nature Genetics.
47.
2015
Network-Based Integration of GWAS and Gene Expression Identifies a HOX-Centric Network Associated with Serous Ovarian Cancer Risk.
Cancer Epidemiology Biomarkers & Prevention.
24.
2015
Obesity and survival among women with ovarian cancer: results from the Ovarian Cancer Association Consortium.
British Journal of Cancer.
113.
2015
Polymorphisms in a Putative Enhancer at the 10q21.2 Breast Cancer Risk Locus Regulate NRBF2 Expression.
American Journal of Human Genetics.
97.
2015
Prediction of Breast Cancer Risk Based on Profiling With Common Genetic Variants.
Journal of the National Cancer Institute.
107.
2015
Shared genetics underlying epidemiological association between endometriosis and ovarian cancer.
Human Molecular Genetics.
24.
2015
A large-scale assessment of two-way SNP interactions in breast cancer susceptibility using 46 450 cases and 42 461 controls from the breast cancer association consortium.
Human Molecular Genetics.
23.
2014
ABCA Transporter Gene Expression and Poor Outcome in Epithelial Ovarian Cancer.
Journal of the National Cancer Institute.
106.
2014
Common non-synonymous SNPs associated with breast cancer susceptibility: findings from the Breast Cancer Association Consortium.
Human Molecular Genetics.
23.
2014
Consortium analysis of gene and gene–folate interactions in purine and pyrimidine metabolism pathways with ovarian carcinoma risk.
Molecular Nutrition & Food Research.
58.
2014
Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation.
Nature Communications.
5.
2014
FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium.
British Journal of Cancer.
110.
2014
Genetic Predisposition to In Situ and Invasive Lobular Carcinoma of the Breast.
PLOS Genetics.
10.
2014
Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study.
Breast Cancer Research.
16.
2014
Genetic variation in mitotic regulatory pathway genes is associated with breast tumor grade.
Human Molecular Genetics.
23.
2014
Genetic variation in the lymphotoxin-α (LTA)/tumour necrosis factor-α (TNFα) locus as a risk factor for idiopathic achalasia.
Gut.
63.
2014
Genome-wide association study of subtype-specific epithelial ovarian cancer risk alleles using pooled DNA.
Human Genetics.
133.
2014
Identification of New Genetic Susceptibility Loci for Breast Cancer Through Consideration of Gene‐Environment Interactions.
Genetic Epidemiology.
38.
2014
Large-Scale Evaluation of Common Variation in Regulatory T Cell–Related Genes and Ovarian Cancer Outcome.
Cancer Immunology Research.
2.
2014
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
Nature.
514.
2014
Risk of Ovarian Cancer and the NF-κB Pathway: Genetic Association with IL1A and TNFSF10.
Cancer Research.
74.
2014
Variation in NF-κB Signaling Pathways and Survival in Invasive Epithelial Ovarian Cancer.
Cancer Epidemiology Biomarkers & Prevention.
23.
2014
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dataset
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MOESM1 of Prediction and clinical utility of a contralateral breast cancer risk model.
springer-nature.
2019
MOESM2 of Prediction and clinical utility of a contralateral breast cancer risk model.
springer-nature.
2019
Association of variants in small GTPase genes with epithelial ovarian cancer risk (p-value<10−4) and functional annotation..
public-library-of-science.
2018
Variants in genes encoding small GTPases and association with epithelial ovarian cancer susceptibility.
public-library-of-science.
2018
Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk.
public-library-of-science.
2015
Evidence of Gene–Environment Interactions between Common Breast Cancer Susceptibility Loci and Established Environmental Risk Factors.
public-library-of-science.
2015
Identification of a BRCA2-Specific Modifier Locus at 6p24 Related to Breast Cancer Risk.
public-library-of-science.
2015
The most significant SNPs in the transport pathway genes and risk of EOC by histology, invasiveness, and race/ethnicity1..
public-library-of-science.
2015
Top SNPs associated with SER EOC across racial groups..
public-library-of-science.
2015
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hide from search
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Associations between selected SNPs and breast cancer risk in Caucasians, overall and by ER status (estimated per-allele odds ratios and 95% confidence intervals)1..
public-library-of-science.
2013
Breast cancer hazard ratios (HR) and 95% confidence intervals (CI) of novel breast cancer loci with P-values of association <10−5 among BRCA2 mutation carriers..
public-library-of-science.
2013
List of participating studies and number of Caucasian subjects included in at least one GxE analysis..
public-library-of-science.
2013
Main effects for the epidemiologic variables included in the analyses, derived from population-based studies only1..
public-library-of-science.
2013
Per allele hazard ratios (HR) and 95% confidence intervals (CI) of previously published breast cancer loci among BRCA2 mutation carriers from previous reports and from the iCOGS array, ordered by statistical significance of the region..
public-library-of-science.
2013
Per-allele odds ratios and 95% confidence intervals for SNPs by environmental risk factors of breast cancer showing interaction P-value<10−3, overall and by estrogen receptor status..
public-library-of-science.
2013
Analysis of Over 10,000 Cases Finds No Association between Previously Reported Candidate Polymorphisms and Ovarian Cancer Outcome.
Cancer Epidemiology Biomarkers & Prevention.
2013
Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer.
Nature Communications.
2013
Fine-Scale Mapping of the FGFR2 Breast Cancer Risk Locus: Putative Functional Variants Differentially Bind FOXA1 and E2F1.
American Journal of Human Genetics.
2013
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
Nature Genetics.
2013
Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31.
Nature Communications.
2013
Identification of a BRCA2-Specific Modifier Locus at 6p24 Related to Breast Cancer Risk.
PLOS Genetics.
2013
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer.
Nature Genetics.
2013
Association of haplotypes composed of rs2046210 and rs12662670 with breast cancer..
public-library-of-science.
2012
Association of rs2046210 and rs12662670 with breast cancer..
public-library-of-science.
2012
Association of rs2046210 and rs12662670 with risk of ER−*/ER+** breast cancer..
public-library-of-science.
2012
Comparison of 6q25 Breast Cancer Hits from Asian and European Genome Wide Association Studies in the Breast Cancer Association Consortium (BCAC).
public-library-of-science.
2012
DistributionA of selected
characteristics between cases and controls..
public-library-of-science.
2011
Odds ratios (OR) and 95% confidence intervals (CI)A between variants in
DCN and LUM genes and serous
epithelial ovarian cancer risk..
public-library-of-science.
2011
Per-allele odds ratios (OR) and 95% confidence intervals (CI) at
DCN rs3138165 with serous epithelial ovarian cancer
across strata of risk factors..
public-library-of-science.
2011
Polymorphisms in Stromal Genes and Susceptibility to Serous
Epithelial Ovarian Cancer: A Report from the Ovarian Cancer Association
Consortium.
public-library-of-science.
2011
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preprint