selected publications
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academic article
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A comparative study of branched and linear mannitol-based amphiphiles on membrane protein stability.
Analyst.
143.
2018
An Engineered Lithocholate‐Based Facial Amphiphile Stabilizes Membrane Proteins: Assessing the Impact of Detergent Customizability on Protein Stability.
Chemistry - A European Journal.
24.
2018
Neuropsychiatric disease–associated genetic variants of the dopamine transporter display heterogeneous molecular phenotypes.
Journal of Biological Chemistry.
293.
2018
Rationally Engineered Tandem Facial Amphiphiles for Improved Membrane Protein Stabilization Efficacy.
ChemBioChem.
19.
2018
Steroid‐Based Amphiphiles for Membrane Protein Study: The Importance of Alkyl Spacers for Protein Stability.
ChemBioChem.
19.
2018
Substrate-modulated unwinding of transmembrane helices in the NSS transporter LeuT.
Science Advances.
4.
2018
Vitamin E-based glycoside amphiphiles for membrane protein structural studies.
Organic & Biomolecular Chemistry.
16.
2018
Butane-1,2,3,4-tetraol-based amphiphilic stereoisomers for membrane protein study: importance of chirality in the linker region.
Chemical Science.
8.
2017
Conformationally Preorganized Diastereomeric Norbornane-Based Maltosides for Membrane Protein Study: Implications of Detergent Kink for Micellar Properties..
Journal of the American Chemical Society.
139.
2017
Dendronic trimaltoside amphiphiles (DTMs) for membrane protein study.
Chemical Science.
8.
2017
Direct assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR.
eLife.
6.
2017
New penta-saccharide-bearing tripod amphiphiles for membrane protein structure studies.
Analyst.
142.
2017
Resorcinarene‐Based Facial Glycosides: Implication of Detergent Flexibility on Membrane‐Protein Stability.
Chemistry - A European Journal.
23.
2017
Structure-Activity Relationship Studies on a Series of 3α-[Bis(4-fluorophenyl)methoxy]tropanes and 3α-[Bis(4-fluorophenyl)methylamino]tropanes As Novel Atypical Dopamine Transporter (DAT) Inhibitors for the Treatment of Cocaine Use Disorders..
Journal of Medicinal Chemistry.
60.
2017
Tandem malonate-based glucosides (TMGs) for membrane protein structural studies.
Scientific Reports.
7.
2017
The Isomeric Preference of an Atypical Dopamine Transporter Inhibitor Contributes to Its Selection of the Transporter Conformation..
ACS Chemical Neuroscience.
8.
2017
X-ray structure based evaluation of analogs of citalopram: Compounds with increased affinity and selectivity compared with R-citalopram for the allosteric site (S2) on hSERT.
Bioorganic & Medicinal Chemistry Letters.
27.
2017
A class of rigid linker-bearing glucosides for membrane protein structural study.
Chemical Science.
7.
2016
Accessible Mannitol‐Based Amphiphiles (MNAs) for Membrane Protein Solubilisation and Stabilisation.
Chemistry - A European Journal.
22.
2016
Conformational Dynamics on the Extracellular Side of LeuT Controlled by Na+ and K+ Ions and the Protonation State of Glu290.
Journal of Biological Chemistry.
291.
2016
Highly Branched Pentasaccharide-Bearing Amphiphiles for Membrane Protein Studies..
Journal of the American Chemical Society.
138.
2016
Isomeric Detergent Comparison for Membrane Protein Stability: Importance of Inter‐Alkyl‐Chain Distance and Alkyl Chain Length.
ChemBioChem.
17.
2016
Mesitylene‐Cored Glucoside Amphiphiles (MGAs) for Membrane Protein Studies: Importance of Alkyl Chain Density in Detergent Efficacy.
Chemistry - A European Journal.
22.
2016
Novel and High Affinity 2-[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) Analogues as Atypical Dopamine Transporter Inhibitors..
Journal of Medicinal Chemistry.
59.
2016
Structure–activity relationship studies of citalopram derivatives: examining substituents conferring selectivity for the allosteric site in the 5‐HT transporter.
British Journal of Pharmacology.
173.
2016
Tandem neopentyl glycol maltosides (TNMs) for membrane protein stabilisation.
Chemical Communications.
52.
2016
The Environment Shapes the Inner Vestibule of LeuT.
PLoS Computational Biology.
12.
2016
Transition metal ion FRET uncovers K+ regulation of a neurotransmitter/sodium symporter.
Nature Communications.
7.
2016
Deoxycholate‐Based Glycosides (DCGs) for Membrane Protein Stabilisation.
ChemBioChem.
16.
2015
Grafted biomembranes containing membrane proteins – the case of the leucine transporter.
Soft Matter.
11.
2015
Maltose neopentyl glycol-3 (MNG-3) analogues for membrane protein study.
Analyst.
140.
2015
Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters.
Journal of Biological Chemistry.
290.
2015
Novel Xylene‐Linked Maltoside Amphiphiles (XMAs) for Membrane Protein Stabilisation.
Chemistry - A European Journal.
21.
2015
Substrate-induced Unlocking of the Inner Gate Determines the Catalytic Efficiency of a Neurotransmitter:Sodium Symporter.
Journal of Biological Chemistry.
290.
2015
The use of LeuT as a model in elucidating binding sites for substrates and inhibitors in neurotransmitter transporters.
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism.
1850.
2015
A Conserved Salt Bridge between Transmembrane Segments 1 and 10 Constitutes an Extracellular Gate in the Dopamine Transporter.
Journal of Biological Chemistry.
289.
2014
Elucidation of structural elements for selectivity across monoamine transporters: novel 2-[(diphenylmethyl)sulfinyl]acetamide (modafinil) analogues..
Journal of Medicinal Chemistry.
57.
2014
Missense dopamine transporter mutations associate with adult parkinsonism and ADHD.
Journal of Clinical Investigation.
124.
2014
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chapter
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CHAPTER 16 Allosteric Binding in the Serotonin Transporter – Pharmacology, Structure, Function and Potential Use as a Novel Drug Target.
Royal Society of Chemistry (RSC).
2016
-
dataset
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Structure–Activity
Relationships for a Series
of (Bis(4-fluorophenyl)methyl)sulfinyl Alkyl Alicyclic Amines at the
Dopamine Transporter: Functionalizing the Terminal Nitrogen Affects
Affinity, Selectivity, and Metabolic Stability.
american-chemical-society.
2019
Structure–Activity
Relationship Studies on
a Series of 3α-[Bis(4-fluorophenyl)methoxy]tropanes and 3α-[Bis(4-fluorophenyl)methylamino]tropanes
As Novel Atypical Dopamine Transporter (DAT) Inhibitors for the Treatment
of Cocaine Use Disorders.
american-chemical-society.
2017
Structure–Activity
Relationship Studies on
a Series of 3α-[Bis(4-fluorophenyl)methoxy]tropanes and 3α-[Bis(4-fluorophenyl)methylamino]tropanes
As Novel Atypical Dopamine Transporter (DAT) Inhibitors for the Treatment
of Cocaine Use Disorders.
american-chemical-society.
2017
Structure–Activity
Relationship Studies on
a Series of 3α-[Bis(4-fluorophenyl)methoxy]tropanes and 3α-[Bis(4-fluorophenyl)methylamino]tropanes
As Novel Atypical Dopamine Transporter (DAT) Inhibitors for the Treatment
of Cocaine Use Disorders.
american-chemical-society.
2017
Novel and High
Affinity 2‑[(Diphenylmethyl)sulfinyl]acetamide
(Modafinil) Analogues as Atypical Dopamine Transporter Inhibitors.
american-chemical-society.
2016
The Environment Shapes the Inner Vestibule of LeuT.
public-library-of-science.
2016
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hide from search
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A rhodamine-labeled citalopram analogue as a high-affinity fluorescent probe for the serotonin transporter.
Bioorganic & Medicinal Chemistry Letters.
2013
A virtual high-throughput screening approach to the discovery of novel inhibitors of the bacterial leucine transporter, LeuT.
Molecular Membrane Biology.
2013
Correction to “Tandem Facial Amphiphiles for Membrane Protein Stabilization”.
Journal of the American Chemical Society.
2013
Design and synthesis of 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile (citalopram) analogues as novel probes for the serotonin transporter S1 and S2 binding sites..
Journal of Medicinal Chemistry.
2013
Glucose - Neopentyl Glycol (GNG) amphiphiles for membrane protein study.
Chemical Communications.
2013
Novel Tripod Amphiphiles for Membrane Protein Analysis.
Chemistry - A European Journal.
2013
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preprint