selected publications
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academic article
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A Type III-B Cmr effector complex catalyzes the synthesis of cyclic oligoadenylate second messengers by cooperative substrate binding.
Nucleic Acids Research.
46.
2018
Conformational Activation Promotes CRISPR-Cas12a Catalysis and Resetting of the Endonuclease Activity.
Cell.
175.
2018
Molecular basis of Tousled-Like Kinase 2 activation.
Nature Communications.
9.
2018
Understanding the indirect DNA read-out specificity of I-CreI Meganuclease.
Scientific Reports.
8.
2018
A novel TPR–BEN domain interaction mediates PICH–BEND3 association.
Nucleic Acids Research.
45.
2017
Allosteric regulation of Csx1, a type IIIB-associated CARF domain ribonuclease by RNAs carrying a tetraadenylate tail.
Nucleic Acids Research.
45.
2017
Assembly of Francisella novicida Cpf1 endonuclease in complex with guide RNA and target DNA.
Acta Crystallographica Section F: Structural Biology Communications.
73.
2017
Class 2 CRISPR–Cas RNA-guided endonucleases: Swiss Army knives of genome editing.
Nature Structural & Molecular Biology.
24.
2017
Electron Microscopy Structural Insights into CPAP Oligomeric Behavior: A Plausible Assembly Process of a Supramolecular Scaffold of the Centrosome.
Frontiers in Molecular Biosciences.
4.
2017
Structure and dynamics of mesophilic variants from the homing endonuclease I-DmoI.
Journal of Computer-Aided Molecular Design.
31.
2017
Structure of the Cpf1 endonuclease R-loop complex after target DNA cleavage.
Nature.
546.
2017
A Conserved Motif Provides Binding Specificity to the PP2A-B56 Phosphatase.
Molecular Cell.
63.
2016
A PTIP–PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex.
Genes & Development.
30.
2016
Characterization of the NTPR and BD1 interacting domains of the human PICH–BEND3 complex.
Acta Crystallographica Section F: Structural Biology Communications.
72.
2016
Key Players in I-DmoI Endonuclease Catalysis Revealed from Structure and Dynamics..
ACS Chemical Biology.
11.
2016
Molecular architecture of the recombinant human MCM2-7 helicase in complex with nucleotides and DNA..
Cell Cycle.
15.
2016
Structure of the I-SceI nuclease complexed with its dsDNA target and three catalytic metal ions.
Acta Crystallographica Section F: Structural Biology Communications.
72.
2016
TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stressTRAIP promotes responses to replication stress.
Journal of Cell Biology.
212.
2016
The genome editing revolution: A CRISPR‐Cas TALE off‐target story.
Inside the Cell.
1.
2016
The genome editing revolution: A CRISPR‐Cas TALE off‐target story.
BioEssays.
38.
2016
Crystal Structure of the Homing Endonuclease I-CvuI Provides a New Template for Genome Modification.
Journal of Biological Chemistry.
290.
2015
Engineering a Nickase on the Homing Endonuclease I-DmoI Scaffold.
Journal of Biological Chemistry.
290.
2015
Functional and in silico assessment of MAX variants of unknown significance.
Journal of Molecular Medicine.
93.
2015
Structure of p15PAF–PCNA complex and implications for clamp sliding during DNA replication and repair.
Nature Communications.
6.
2015
Visualizing phosphodiester-bond hydrolysis by an endonuclease.
Nature Structural & Molecular Biology.
22.
2015
Comprehensive analysis of the specificity of transcription activator-like effector nucleases.
Nucleic Acids Research.
42.
2014
XTACC3–XMAP215 association reveals an asymmetric interaction promoting microtubule elongation.
Nature Communications.
5.
2014
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patent
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preprint