selected publications
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academic article
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The Role of Mitochondrial Dysfunction in the Progression of Alzheimer's Disease..
Current Medicinal Chemistry.
25.
2019
Initial brain aging: heterogeneity of mitochondrial size is associated with decline in complex I-linked respiration in cortex and hippocampus.
Neurobiology of Aging.
61.
2018
The inhibitors of soluble adenylate cyclase 2-OHE, KH7, and bithionol compromise mitochondrial ATP production by distinct mechanisms.
Biochemical Pharmacology.
155.
2018
Bacterial infection increases risk of carcinogenesis by targeting mitochondria.
Seminars in Cancer Biology.
47.
2017
DNA mismatch repair and its many roles in eukaryotic cells.
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis.
773.
2017
Disturbed mitochondrial function restricts glutamate uptake in the human Müller glia cell line, MIO-M1.
Mitochondrion.
36.
2017
Genomic and functional integrity of the hematopoietic system requires tolerance of oxidative DNA lesions.
Blood.
130.
2017
Human DNA polymerase delta double-mutant D316A;E318A interferes with DNA mismatch repair in vitro.
Nucleic Acids Research.
45.
2017
Involvement of the DNA mismatch repair system in cisplatin sensitivity of testicular germ cell tumours.
Cellular Oncology.
40.
2017
Nanomaterial-induced cell death in pulmonary and hepatic cells following exposure to three different metallic materials: The role of autophagy and apoptosis.
Nanotoxicology.
11.
2017
Predicting the impact of Lynch syndrome-causing missense mutations from structural calculations.
PLOS Genetics.
13.
2017
Rev1 contributes to proper mitochondrial function via the PARP-NAD+-SIRT1-PGC1α axis.
Scientific Reports.
7.
2017
A Novel Rrm3 Function in Restricting DNA Replication via an Orc5-Binding Domain Is Genetically Separable from Rrm3 Function as an ATPase/Helicase in Facilitating Fork Progression.
PLOS Genetics.
12.
2016
Acquired Localized Cutis Laxa due to Increased Elastin Turnover.
Case Reports in Dermatology.
8.
2016
Approaches to diagnose DNA mismatch repair gene defects in cancer.
DNA Repair.
38.
2016
Exonuclease 1 and its versatile roles in DNA repair.
Critical Reviews in Biochemistry and Molecular Biology.
51.
2016
Interventions for age-related diseases: Shifting the paradigm.
Mechanisms of Ageing and Development.
160.
2016
LIFESTAT – Living with statins: An interdisciplinary project on the use of statins as a cholesterol-lowering treatment and for cardiovascular risk reduction.
Scandinavian Journal of Public Health.
44.
2016
Oxidative Stress-Induced Dysfunction of Müller Cells During StarvationDysfunction of Müller Cells During Starvation.
Investigative Ophthalmology & Visual Science.
57.
2016
RECQL4 Promotes DNA End Resection in Repair of DNA Double-Strand Breaks.
Cell Reports.
16.
2016
Associations of subjective vitality with DNA damage, cardiovascular risk factors and physical performance.
Acta Physiologica.
213.
2015
Defective mitochondrial respiration, altered dNTP pools and reduced AP endonuclease 1 activity in peripheral blood mononuclear cells of Alzheimer's disease patients..
Aging.
7.
2015
Human exonuclease 1 (EXO1) activity characterization and its function on flap structures.
Bioscience Reports.
35.
2015
Impaired dynamics and function of mitochondria caused by mtDNA toxicity leads to heart failure.
AJP Heart and Circulatory Physiology.
309.
2015
Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice.
Genes & Development.
29.
2015
Increased deoxythymidine triphosphate levels is a feature of relative cognitive decline.
Mitochondrion.
25.
2015
Mitochondria in Health and Disease – 3rd Annual Conference of Society for Mitochondrial Research and Medicine – 19–20 December 2013 — Bengaluru, India.
Mitochondrion.
20.
2015
Neuroprotective modifications in retinal Müller cells due to oxidative stress and energy restriction.
Acta Ophthalmologica.
93.
2015
The challenges of human population ageing.
Age and Ageing.
44.
2015
Dynamics of the DNA repair proteins WRN and BLM in the nucleoplasm and nucleoli.
European Biophysics Journal.
43.
2014
Enterococcus faecalis Infection and Reactive Oxygen Species Down-Regulates the miR-17-92 Cluster in Gastric Adenocarcinoma Cell Culture.
Genes.
5.
2014
Functional implications of the p.Cys680Arg mutation in the MLH1 mismatch repair protein.
Molecular Genetics & Genomic Medicine.
2.
2014
Impact of bacterial infections on aging and cancer: Impairment of DNA repair and mitochondrial function of host cells.
Experimental Gerontology.
56.
2014
Introducing the hypothome: a way to integrate predicted proteins in interactomes..
International Journal of Bioinformatics Research and Applications.
10.
2014
Mitochondria in biology and medicine — 2012.
Mitochondrion.
16.
2014
The role of RecQ helicases in non-homologous end-joining.
Critical Reviews in Biochemistry and Molecular Biology.
49.
2014
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chapter
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EXO1 (Exonuclease 1).
Springer Nature.
2016
Assessing Genetic Variants of Uncertain Significance: The Example of Lynch Syndrome.
Wiley.
2014
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dataset
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Predicting the impact of Lynch syndrome-causing missense mutations from structural calculations.
public-library-of-science.
2017
Stability and function of selected MSH2 mutant proteins..
public-library-of-science.
2017
A Novel Rrm3 Function in Restricting DNA Replication via an Orc5-Binding Domain Is Genetically Separable from Rrm3 Function as an ATPase/Helicase in Facilitating Fork Progression.
public-library-of-science.
2016
Accumulation of Forward Mutations at CAN1 and Gross-chromosomal Rearrangements in Untreated rrm3 Mutants and after Treatment with Genotoxic Agents.
public-library-of-science.
2016
Effect of Deletions of RRM3, RAD5, RDH54 on Accumulation of Gross-Chromosomal Rearrangements in the Presence or Absence of Genotoxic Agents.
public-library-of-science.
2016
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hide from search
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Enterococcus faecalis Infection Causes Inflammation, Intracellular Oxphos-Independent ROS Production, and DNA Damage in Human Gastric Cancer Cells.
public-library-of-science.
2013
Genes involved in the inflammatory response of MKN74 cells identified by microarray analysis..
public-library-of-science.
2013
DNA damage response, bioenergetics, and neurological disease: The challenge of maintaining brain health in an aging human population.
Mechanisms of Ageing and Development.
2013
Enterococcus faecalis Infection Causes Inflammation, Intracellular Oxphos-Independent ROS Production, and DNA Damage in Human Gastric Cancer Cells.
PLoS ONE.
2013
Functional examination of MLH1, MSH2, and MSH6 intronic mutations identified in Danish colorectal cancer patients.
BMC Medical Genetics.
2013
Genetic screens to identify pathogenic gene variants in the common cancer predisposition Lynch syndrome.
Proceedings of the National Academy of Sciences of the United States of America.
2013
Helicobacter pylori infection affects mitochondrial function and DNA repair, thus, mediating genetic instability in gastric cells.
Mechanisms of Ageing and Development.
2013
Natural selection of mitochondria during somatic lifetime promotes healthy aging.
Frontiers in Neuroenergetics.
2013
Relationships between human vitality and mitochondrial respiratory parameters, reactive oxygen species production and dNTP levels in peripheral blood mononuclear cells..
Aging.
2013
Response to: Design of a Core Classification Process for DNA Mismatch Repair Variations of A Priori Unknown Functional Significance.
Human Mutation.
2013