selected publications
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academic article
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A Robust Proton Flux (pHlux) Assay for Studying the Function and Inhibition of the Influenza A M2 Proton Channel..
Biochemistry.
57.
2018
An NAD+-Dependent Sirtuin Depropionylase and Deacetylase (Sir2La) from the Probiotic Bacterium Lactobacillus acidophilus NCFM..
Biochemistry.
57.
2018
Direct Peptide Cyclization and One-Pot Modification Using the MeDbz Linker..
The Journal of Organic Chemistry.
83.
2018
Histone Deacetylase 11 Is an ε-N-Myristoyllysine Hydrolase.
Cell Chemical Biology.
25.
2018
Random Mutagenesis Analysis of the Influenza A M2 Proton Channel Reveals Novel Resistance Mutants..
Biochemistry.
57.
2018
Synthesis of Trifluoromethyl Ketone Containing Amino Acid Building Blocks for the Preparation of Peptide-Based Histone Deacetylase (HDAC) Inhibitors.
Synthesis.
50.
2018
Backbone-Fluorinated 1,2,3-Triazole-Containing Dipeptide Surrogates..
The Journal of Organic Chemistry.
82.
2017
Chemical Editing of Macrocyclic Natural Products and Kinetic Profiling Reveal Slow, Tight-Binding Histone Deacetylase Inhibitors with Picomolar Affinities..
Biochemistry.
56.
2017
Corrigendum: Cross-Talk between Staphylococcus aureus and Other Staphylococcal Species via the agr Quorum Sensing System.
Frontiers in Microbiology.
8.
2017
Corrigendum: Cross-Talk between Staphylococcus aureus and Other Staphylococcal Species via the agr Quorum Sensing System.
Frontiers in Microbiology.
8.
2017
Cyclic tetrapeptide HDAC inhibitors as potential therapeutics for spinal muscular atrophy: Screening with iPSC-derived neuronal cells.
Bioorganic & Medicinal Chemistry Letters.
27.
2017
Frontispiece: Mechanism‐Based Inhibitors of the Human Sirtuin 5 Deacylase: Structure–Activity Relationship, Biostructural, and Kinetic Insight.
Angewandte Chemie International Edition.
56.
2017
Frontispiz: Mechanism‐Based Inhibitors of the Human Sirtuin 5 Deacylase: Structure–Activity Relationship, Biostructural, and Kinetic Insight.
Angewandte Chemie.
129.
2017
Mechanism‐Based Inhibitors of the Human Sirtuin 5 Deacylase: Structure–Activity Relationship, Biostructural, and Kinetic Insight.
Angewandte Chemie.
129.
2017
Mechanism‐Based Inhibitors of the Human Sirtuin 5 Deacylase: Structure–Activity Relationship, Biostructural, and Kinetic Insight.
Angewandte Chemie International Edition.
56.
2017
Metabolic control by sirtuins and other enzymes that sense NAD+, NADH, or their ratio.
Biochimica et Biophysica Acta (BBA) - Bioenergetics.
1858.
2017
Natural and Synthetic Macrocyclic Inhibitors of the Histone Deacetylase Enzymes.
ChemBioChem.
18.
2017
SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion.
Cell Metabolism.
25.
2017
Scalable and Purification-Free Synthesis of a Myristoylated Fluorogenic Sirtuin Substrate.
Synlett.
28.
2017
Structure-Activity Relationship Study Based on Autoinducing Peptide (AIP) from Dog Pathogen S. schleiferi..
Organic Letters.
19.
2017
A Continuous, Fluorogenic Sirtuin 2 Deacylase Assay: Substrate Screening and Inhibitor Evaluation..
Journal of Medicinal Chemistry.
59.
2016
A potent trifluoromethyl ketone histone deacetylase inhibitor exhibits class-dependent mechanism of action.
MedChemComm.
7.
2016
An acetylation photoswitch.
Nature Chemical Biology.
12.
2016
Cross-Talk between Staphylococcus aureus and Other Staphylococcal Species via the agr Quorum Sensing System.
Frontiers in Microbiology.
7.
2016
Innovative Strategies for Selective Inhibition of Histone Deacetylases.
Cell Chemical Biology.
23.
2016
Investigating the Sensitivity of NAD+-dependent Sirtuin Deacylation Activities to NADH.
Journal of Biological Chemistry.
291.
2016
Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation.
Cell Reports.
17.
2016
The agr Inhibitors Solonamide B and Analogues Alter Immune Responses to Staphylococccus aureus but Do Not Exhibit Adverse Effects on Immune Cell Functions.
PLoS ONE.
11.
2016
Effects of thionation and fluorination on cis-trans isomerization in tertiary amides: an investigation of N-alkylglycine (peptoid) rotamers..
The Journal of Organic Chemistry.
80.
2015
Triangular prism-shaped β-peptoid helices as unique biomimetic scaffolds.
Nature Communications.
6.
2015
β-Peptoid Foldamers at Last..
Accounts of Chemical Research.
48.
2015
An Update on Lysine Deacylases Targeting the Expanding “Acylome”.
ChemMedChem.
9.
2014
An azumamide C analogue without the zinc-binding functionality.
MedChemComm.
5.
2014
Back Cover: The Effect of Various Zinc Binding Groups on Inhibition of Histone Deacetylases 1–11 (ChemMedChem 3/2014).
ChemMedChem.
9.
2014
Guanidino groups greatly enhance the action of antimicrobial peptidomimetics against bacterial cytoplasmic membranes.
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism.
1838.
2014
Lysine Glutarylation Is a Protein Posttranslational Modification Regulated by SIRT5.
Cell Metabolism.
19.
2014
Methyl effect in azumamides provides insight into histone deacetylase inhibition by macrocycles..
Journal of Medicinal Chemistry.
57.
2014
The Effect of Various Zinc Binding Groups on Inhibition of Histone Deacetylases 1–11.
ChemMedChem.
9.
2014
Total synthesis and structural validation of cyclodepsipeptides solonamide A and B.
Tetrahedron.
70.
2014
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dataset
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Functionalized Helical
β‑Peptoids.
american-chemical-society.
2019
Table_1_Effect of Co-inhabiting Coagulase Negative Staphylococci on S. aureus agr Quorum Sensing, Host Factor Binding, and Biofilm Formation.DOCX.
frontiers.
2019
A Continuous, Fluorogenic
Sirtuin 2 Deacylase Assay: Substrate Screening and Inhibitor Evaluation.
american-chemical-society.
2016
The agr Inhibitors Solonamide B and Analogues Alter Immune Responses to Staphylococccus aureus but Do Not Exhibit Adverse Effects on Immune Cell Functions.
public-library-of-science.
2016
Effects of Thionation
and Fluorination on Cis–Trans
Isomerization in Tertiary Amides: An Investigation of N‑Alkylglycine (Peptoid) Rotamers.
american-chemical-society.
2015
Methyl Effect in Azumamides
Provides Insight Into
Histone Deacetylase Inhibition by Macrocycles.
american-chemical-society.
2014
Methyl Effect in Azumamides
Provides Insight Into
Histone Deacetylase Inhibition by Macrocycles.
american-chemical-society.
2014
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hide from search
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Cis–Trans Amide Bond Rotamers in β‑Peptoids and
Peptoids: Evaluation
of Stereoelectronic Effects in Backbone and Side Chains.
american-chemical-society.
2013
Cis–Trans Amide Bond Rotamers in β‑Peptoids and
Peptoids: Evaluation
of Stereoelectronic Effects in Backbone and Side Chains.
american-chemical-society.
2013
Cis–Trans Amide Bond Rotamers in β‑Peptoids and
Peptoids: Evaluation
of Stereoelectronic Effects in Backbone and Side Chains.
american-chemical-society.
2013
Cis-trans amide bond rotamers in β-peptoids and peptoids: evaluation of stereoelectronic effects in backbone and side chains..
Journal of the American Chemical Society.
2013
Total synthesis and full histone deacetylase inhibitory profiling of Azumamides A-E as well as β²- epi-Azumamide E and β³-epi-Azumamide E..
Journal of Medicinal Chemistry.
2013
Inhibition of human placenta alkaline phosphatase (HPAP), bovine kidney tissue non-specific alkaline phosphatase (TNAP) and sirtuin 1 (SIRT1) by selected compounds..
public-library-of-science.
2012
Results of in vitro angiogenesis inhibition of levamisole and its derivatives in comparison with suramin (5), vehicle (DMSO), and medium alone, as observed by HUVEC number and morphology..
public-library-of-science.
2012
Table S1 - Synthesis and Antiangiogenic Activity of N-Alkylated Levamisole Derivatives.
public-library-of-science.
2012
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preprint
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Histone Deacetylase 11 is an ε-N-Myristoyllysine Hydrolase.
bioRxiv.
2017