selected publications
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academic article
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Identifying and avoiding off-target effects of RNase H-dependent antisense oligonucleotides in mice.
Nucleic Acids Research.
46.
2018
Locked nucleic acid: modality, diversity, and drug discovery.
Drug Discovery Today.
23.
2018
Managing the sequence-specificity of antisense oligonucleotides in drug discovery.
Nucleic Acids Research.
45.
2017
RNase H sequence preferences influence antisense oligonucleotide efficiency.
Nucleic Acids Research.
45.
2017
Dissecting the target specificity of RNase H recruiting oligonucleotides using massively parallel reporter analysis of short RNA motifs.
Nucleic Acids Research.
43.
2015
A Kinetic Model Explains Why Shorter and Less Affine Enzyme-recruiting Oligonucleotides Can Be More Potent.
Molecular Therapy - Nucleic Acids.
3.
2014
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Hepatotoxic Potential of Therapeutic Oligonucleotides Can Be Predicted from Their Sequence and Modification Pattern.
Nucleic Acid Therapeutics.
2013
STAT5-mediated expression of oncogenic miR-155 in cutaneous T-cell lymphoma.
Cell Cycle.
2013
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patent