selected publications
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academic article
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Central and Peripheral Nervous System Progenitors Derived from Human Pluripotent Stem Cells Reveal a Unique Temporal and Cell-Type Specific Expression of PMCAs.
Frontiers in Cell and Developmental Biology.
6.
2018
Confirming chemical clocks: asteroseismic age dissection of the Milky Way disk(s).
Monthly Notices of the Royal Astronomical Society.
2018
Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases.
Nature Communications.
9.
2018
Interactions of a Bacterial Cu(I)-ATPase with a Complex Lipid Environment..
Biochemistry.
57.
2018
Invisible detergents for structure determination of membrane proteins by small‐angle neutron scattering.
The FEBS Journal.
285.
2018
Jens Christian Skou (1918-2018)..
Science.
361.
2018
Membrane‐protein crystals for neutron diffraction.
Acta Crystallographica Section D, Structural Biology.
74.
2018
Nonlinear relationship between ER Ca2+ depletion versus induction of the unfolded protein response, autophagy inhibition, and cell death.
Cell Calcium.
76.
2018
Brief encounters of cytochrome c.
The EMBO Journal.
36.
2017
Characterization of ATP7A missense mutants suggests a correlation between intracellular trafficking and severity of Menkes disease.
Scientific Reports.
7.
2017
Dynamics of P-type ATPase transport revealed by single-molecule FRET.
Nature.
551.
2017
High phosphatidylinositol 4-phosphate (PI4P)-dependent ATPase activity for the Drs2p-Cdc50p flippase after removal of its N- and C-terminal extensions.
Journal of Biological Chemistry.
292.
2017
High-precision abundances of elements in Kepler LEGACY stars - Verification of trends with stellar age.
Astronomy & Astrophysics.
608.
2017
High-precision abundances of elements in stars with asteroseismic ages.
Proceedings of the International Astronomical Union.
13.
2017
Improved Model of Proton Pump Crystal Structure Obtained by Interactive Molecular Dynamics Flexible Fitting Expands the Mechanistic Model for Proton Translocation in P-Type ATPases.
Frontiers in Physiology.
8.
2017
Inhibition of the sarco/endoplasmic reticulum (ER) Ca2+-ATPase by thapsigargin analogs induces cell death via ER Ca2+ depletion and the unfolded protein response.
Journal of Biological Chemistry.
292.
2017
Sc and neutron-capture abundances in Galactic low- and high-α field halo stars.
Monthly Notices of the Royal Astronomical Society.
2017
Sun‐like stars unlike the Sun: Clues for chemical anomaliesof cool stars.
Astronomische Nachrichten.
338.
2017
The [Y/Mg] clock works for evolved solar metallicity stars.
Astronomy & Astrophysics.
604.
2017
The role of transmembrane segment 5 (TM5) in Na2 release and the conformational transition of neurotransmitter:sodium symporters toward the inward-open state.
Journal of Biological Chemistry.
292.
2017
A conserved leucine occupies the empty substrate site of LeuT in the Na+-free return state.
Nature Communications.
7.
2016
Cognitive deficits caused by a disease-mutation in the α3 Na+/K+-ATPase isoform.
Scientific Reports.
6.
2016
Correlation between lithium abundances and ages of solar twin stars.
Astronomy & Astrophysics.
587.
2016
Crystal Structure of an Ammonia-Permeable Aquaporin.
PLOS Biology.
14.
2016
Crystal Structure of the Vanadate-Inhibited Ca2+-ATPase.
Structure.
24.
2016
Engineering a Prototypic P-type ATPase Listeria monocytogenes Ca(2+)-ATPase 1 for Single-Molecule FRET Studies..
Bioconjugate Chemistry.
27.
2016
Erratum: Reappraising the effects of artemisinin on the ATPase activity of PfATP6 and SERCA1a E255L expressed in Xenopus laevis oocytes.
Nature Structural & Molecular Biology.
23.
2016
Expression strategies for structural studies of eukaryotic membrane proteins.
Current Opinion in Structural Biology.
38.
2016
Glutamate-system defects behind psychiatric manifestations in a familial hemiplegic migraine type 2 disease-mutation mouse model.
Scientific Reports.
6.
2016
Initiating heavy-atom-based phasing by multi-dimensional molecular replacement.
Acta Crystallographica Section D, Structural Biology.
72.
2016
Isolation, crystallization and crystal structure determination of bovine kidney Na+,K+-ATPase.
Acta Crystallographica Section F: Structural Biology Communications.
72.
2016
Non-LTE analysis of copper abundances for the two distinct halo populations in the solar neighborhood.
Astronomy & Astrophysics.
585.
2016
On the molecular mechanism of flippase- and scramblase-mediated phospholipid transport.
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism.
1861.
2016
Reappraising the effects of artemisinin on the ATPase activity of PfATP6 and SERCA1a E255L expressed in Xenopus laevis oocytes.
Nature Structural & Molecular Biology.
23.
2016
Snapshots of P-Type ATPases - From Crystal Structures to Single-Molecule Studies.
Biophysical Journal.
110.
2016
The α4 isoform of the Na+,K+‐ATPase is tuned for changing extracellular environments.
The FEBS Journal.
283.
2016
Tuning of the Na,K-ATPase by the beta subunit.
Scientific Reports.
6.
2016
A Key Role for TM5 in the Na+-Coupled Alternating-Access Mechanism Revealed by Computational Analysis of the MhsT Structures.
Biophysical Journal.
108.
2015
A sulfur‐based transport pathway in Cu+‐ATPases.
EMBO Reports.
16.
2015
Against the odds? De novo structure determination of a pilin with two cysteine residues by sulfur SAD.
Acta Crystallographica Section D, Structural Biology.
71.
2015
Ages and fundamental properties of Kepler exoplanet host stars from asteroseismology.
Monthly Notices of the Royal Astronomical Society.
452.
2015
Digesting New Elements in Peptide Transport.
Structure.
23.
2015
Discovery of Tricyclic Clerodane Diterpenes as Sarco/Endoplasmic Reticulum Ca(2+)-ATPase Inhibitors and Structure-Activity Relationships..
Journal of Natural Products.
78.
2015
Erratum: Hydrogen bond rotations as a uniform structural tool for analyzing protein architecture.
Nature Communications.
6.
2015
High-precision abundances of elements in solar twin stars - Trends with stellar age and elemental condensation temperature.
Astronomy & Astrophysics.
579.
2015
High-resolution structure of a type IV pilin from the metal-reducing bacterium Shewanella oneidensis.
BMC Structural Biology.
15.
2015
Indications of radiation damage in ferredoxin microcrystals using high-intensity X-FEL beams.
Journal of Synchrotron Radiation.
22.
2015
Membrane proteins — do we catch up with the breathless pace of soluble protein structural biology?.
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism.
1850.
2015
Regulation of the Ca2+-ATPase by cholesterol: A specific or non-specific effect?.
Molecular Membrane Biology.
32.
2015
Structural studies of P-type ATPase–ligand complexes using an X-ray free-electron laser.
IUCrJ.
2.
2015
Structure and Function of Cu(I)- and Zn(II)-ATPases..
Biochemistry.
54.
2015
Structures and characterization of digoxin- and bufalin-bound Na+,K+-ATPase compared with the ouabain-bound complex.
Proceedings of the National Academy of Sciences of the United States of America.
112.
2015
Targeting thapsigargin towards tumors.
Steroids.
97.
2015
A High-Yield Co-Expression System for the Purification of an Intact Drs2p-Cdc50p Lipid Flippase Complex, Critically Dependent on and Stabilized by Phosphatidylinositol-4-Phosphate.
PLoS ONE.
9.
2014
A mechanism for intracellular release of Na+ by neurotransmitter/sodium symporters.
Nature Structural & Molecular Biology.
21.
2014
Brian Clark has died — marking the end of an era: Professor Brian Frederic Carl Clark, founder of Structural Biology Research at Aarhus University, died on Monday, October 6, 2014. Aged 78 years.
IUBMB Life.
66.
2014
Carbon and oxygen abundances in stellar populations.
Astronomy & Astrophysics.
568.
2014
Comparing crystal structures of Ca2+‐ATPase in the presence of different lipids.
The FEBS Journal.
281.
2014
Copper-transporting P-type ATPases use a unique ion-release pathway.
Nature Structural & Molecular Biology.
21.
2014
Crystals of Na+/K+-ATPase with bound cisplatin.
Biochemical Pharmacology.
92.
2014
Dynamics of Transition Metal Transporting P-Type ATPases in Native Membranes.
Biophysical Journal.
106.
2014
Hydrogen bond rotations as a uniform structural tool for analyzing protein architecture.
Nature Communications.
5.
2014
Inhibition of Ubiquitin Proteasome System Rescues the Defective Sarco(endo)plasmic Reticulum Ca2+-ATPase (SERCA1) Protein Causing Chianina Cattle Pseudomyotonia.
Journal of Biological Chemistry.
289.
2014
Large Scale Identification and Categorization of Protein Sequences Using Structured Logistic Regression.
PLoS ONE.
9.
2014
Na(+),K(+)-ATPase isoform selectivity for digitalis-like compounds is determined by two amino acids in the first extracellular loop..
Chemical Research in Toxicology.
27.
2014
RED GIANT STARS FROM SLOAN DIGITAL SKY SURVEY. I. THE GENERAL FIELD.
The Astrophysical Journal.
795.
2014
Revisiting the structure of the Vps10 domain of human sortilin and its interaction with neurotensin.
Protein Science.
23.
2014
S-Palmitoylation and S-Oleoylation of Rabbit and Pig Sarcolipin.
Journal of Biological Chemistry.
289.
2014
STRÖMGREN SURVEY FOR ASTEROSEISMOLOGY AND GALACTIC ARCHAEOLOGY: LET THE SAGA BEGIN*.
The Astrophysical Journal.
787.
2014
Somatic Mutations in the Na,K-ATPase Can Cause Hypertension.
Biophysical Journal.
106.
2014
Structural mechanics and regulation of the Ca2+-ATPase.
Biochimica et Biophysica Acta (BBA) - Bioenergetics.
1837.
2014
Structure and mechanism of Zn2+-transporting P-type ATPases.
Nature.
514.
2014
THREE ANCIENT HALO SUBGIANTS: PRECISE PARALLAXES, COMPOSITIONS, AGES, AND IMPLICATIONS FOR GLOBULAR CLUSTERS*, **, ** *.
The Astrophysical Journal.
792.
2014
Transport Pathway in Cu+ P-Type ATPases.
Biophysical Journal.
106.
2014
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chapter
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Chapter Three Saposin-Lipoprotein Scaffolds for Structure Determination of Membrane Transporters.
Elsevier.
2017
An Introduction to P-type ATPase Research.
Springer Nature.
2016
Reconstitution of Na+,K+-ATPase in Nanodiscs.
Springer Nature.
2016
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dataset
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Crystal Structure of an Ammonia-Permeable Aquaporin.
public-library-of-science.
2016
Crystallographic data and refinement statistics..
public-library-of-science.
2016
Transport rates for ammonia and water in yeast cells expressing AtTIP2;1, HsAQP1, or mutants of HsAQP1 mimicking the selectivity filter of AtTIP2;1..
public-library-of-science.
2016
Discovery of Tricyclic Clerodane Diterpenes as Sarco/Endoplasmic
Reticulum Ca2+-ATPase Inhibitors and Structure–Activity
Relationships.
american-chemical-society.
2015
A High-Yield Co-Expression System for the Purification of an Intact Drs2p-Cdc50p Lipid Flippase Complex, Critically Dependent on and Stabilized by Phosphatidylinositol-4-Phosphate.
public-library-of-science.
2014
Breakdown of P-type ATPase classes found in the UniProtKB dataset..
public-library-of-science.
2014
Comparison of running time of SLR to HMM for task 1..
public-library-of-science.
2014
File S1 - Large Scale Identification and Categorization of Protein Sequences Using Structured Logistic Regression.
public-library-of-science.
2014
Membrane Topology in P-type ATPases..
public-library-of-science.
2014
Overview of the canonical P-type ATPase classes..
public-library-of-science.
2014
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hide from search
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Chemical Abundances as Population Tracers
2013
Chloride binding site of neurotransmitter sodium symporters.
Proceedings of the National Academy of Sciences of the United States of America.
2013
Crystal Structure of Na+, K+-ATPase in the Na+-Bound State.
Science.
2013
Crystal structure of the high-affinity Na+,K+-ATPase–ouabain complex with Mg2+ bound in the cation binding site.
Proceedings of the National Academy of Sciences of the United States of America.
2013
Heterologous expression and purification of an active human TRPV3 ion channel.
The FEBS Journal.
2013
Identifying ligand-binding hot spots in proteins using brominated fragments.
Acta Crystallographica Section F: Structural Biology Communications.
2013
Ion Pathways in the Sarcoplasmic Reticulum Ca2+-ATPase.
Journal of Biological Chemistry.
2013
On Allosteric Modulation of P-Type Cu+-ATPases.
Journal of Molecular Biology.
2013
Probing determinants of cyclopiazonic acid sensitivity of bacterial Ca2+‐ATPases.
The FEBS Journal.
2013
SERCA mutant E309Q binds two Ca2+ ions but adopts a catalytically incompetent conformation.
The EMBO Journal.
2013
Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension.
Nature Genetics.
2013
Special Issue – Signalling. Introduction – Ca2+ signalling and transport in health and disease.
The FEBS Journal.
2013
Structural diversity of calmodulin binding to its target sites.
The FEBS Journal.
2013
The C-terminal cavity of the Na,K-ATPase analyzed by docking and electrophysiology.
Molecular Membrane Biology.
2013
The carbon-to-oxygen ratio in stars with planets.
Astronomy & Astrophysics.
2013
The evolution of C and O abundances in stellar populations.
Proceedings of the International Astronomical Union.
2013
The sarcolipin-bound calcium pump stabilizes calcium sites exposed to the cytoplasm.
Nature.
2013
Water-mediated interactions influence the binding of thapsigargin to sarco/endoplasmic reticulum calcium adenosinetriphosphatase..
Journal of Medicinal Chemistry.
2013
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monograph
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patent
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METHODS AND TOOLS FOR IDENTIFICATION OF RSK/MSK KINASE INHIBITORS
2017
Methods and tools for identification of RSK/MSK kinase inhibitors
2017
CRYSTAL STRUCTURE OF A TYPE IB P-TYPE ATPase
2015
METHODS AND TOOLS FOR IDENTIFICATION OF RSK/MSK KINASE INHIBITORS
2015
METHODS AND TOOLS FOR IDENTIFICATION OF RSK/MSK KINASE INHIBITORS
2015
CRYSTAL STRUCTURE I
2014
CRYSTAL STRUCTURE OF THE SERCA CA2+ ATPASE IN A COMPLEX WITH SARCOLIPIN
2014
METHODS AND TOOLS FOR IDENTIFICATION OF RSK/MSK KINASE INHIBITORS
2014
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preprint