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Targeting the γ-Aminobutyric Acid Type B (GABAB) Receptor Complex: Development of Inhibitors Targeting the K+ Channel Tetramerization Domain (KCTD) Containing Proteins/GABAB Receptor Protein-Protein Interaction.
Sereikaite, Vita , Fritzius, Thorsten , Kasaragod, Vikram B [et al.]
2019, Journal of Medicinal Chemistry, Article
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Five-Membered N-Heterocyclic Scaffolds as Novel Amino Bioisosteres at γ-Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters.
Giraudo, Alessandro , Krall, Jacob , Bavo, Francesco [et al.]
2019, Journal of Medicinal Chemistry, Article
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Aminergic GPCR-Ligand Interactions: A Chemical and Structural Map of Receptor Mutation Data.
Vass, Márton , Podlewska, Sabina , de Esch, Iwan J P [et al.]
2019, Journal of Medicinal Chemistry, Article
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A Comparative Assessment Study of Known Small-Molecule Keap1-Nrf2 Protein-Protein Interaction Inhibitors: Chemical Synthesis, Binding Properties, and Cellular Activity.
Tran, Kim T , Pallesen, Jakob S , Solbak, Sara M Ø [et al.]
2019, Journal of Medicinal Chemistry, Article
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Overview of Recent Strategic Advances in Medicinal Chemistry.
Wu, Gaochan , Zhao, Tong , Kang, Dongwei [et al.]
2019, Journal of Medicinal Chemistry, Article
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Discovery of 2-(Imidazo[1,2- b]pyridazin-2-yl)acetic Acid as a New Class of Ligands Selective for the γ-Hydroxybutyric Acid (GHB) High-Affinity Binding Sites.
Krall, Jacob , Bavo, Francesco , Falk-Petersen, Christina B [et al.]
2019, Journal of Medicinal Chemistry, Article
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Improved RE31 Analogues Containing Modified Nucleic Acid Monomers: Thermodynamic, Structural, and Biological Effects.
Kotkowiak, Weronika , Wengel, Jesper , Scotton, Chris J , Pasternak, Anna
2019, Journal of Medicinal Chemistry, Article
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Philanthotoxin Analogues That Selectively Inhibit Ganglionic Nicotinic Acetylcholine Receptors with Exceptional Potency.
Kachel, Hamid S , Franzyk, Henrik , Mellor, Ian R
2019, Journal of Medicinal Chemistry, Article
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Probing the Existence of a Metastable Binding Site at the β2-Adrenergic Receptor with Homobivalent Bitopic Ligands.
Gaiser, Birgit I , Danielsen, Mia , Marcher-Rørsted, Emil [et al.]
2019, Journal of Medicinal Chemistry, Article
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The Journey of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) from Lab to Clinic.
Namasivayam, Vigneshwaran , Vanangamudi, Murugesan , Kramer, Victor G [et al.]
2019, Journal of Medicinal Chemistry, Article